Effects of cooking oil fume derived fine particulate matter on blood vessel formation through the VEGF/VEGFR2/MEK1/2/ERK1/2/mTOR pathway in human umbilical vein endothelial cells

[Display omitted] •COF-derived PM2.5 inhibited the tube formation of HUVECs in a concentration- dependent manner.•VEGF, VEGFR2, MEK1/2, ERK1/2 and mTOR pathway was involved in the inhibitory effects.•Cell viability gradually decreased after exposure to COF-derived PM2.5. In China, cooking oil fume d...

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Veröffentlicht in:	Environmental toxicology and pharmacology 2019-07, Vol.69, p.112-119
Hauptverfasser:	Zhu, Furong, Cheng, Han, Lei, Ruoqian, Shen, Chaowei, Liu, Jie, Hou, Lijuan, Zhang, Chao, Xu, Yachun, Ding, Rui, Cao, Jiyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Air pollution measurements Angiogenesis Angiopoiesis Blood vessels Cell viability Cooking Cooking oil fume Cooking oils Cytotoxicity Endothelial cells Extracellular signal-regulated kinase Human umbilical vein endothelial cells Indoor air pollution Indoor environments Low birth weight mRNA Particulate matter Particulates PM2.5 Proteins TOR protein Toxicity Tubes Umbilical vein Vascular endothelial growth factor Veins
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