Comparative pharmacokinetics of two extended half‐life FVIII concentrates (Eloctate and Adynovate) in adolescents with hemophilia A: Is there a difference?

Essentials The PK parameters of Eloctate vs Adynovate were compared using one‐stage and chromogenic assays in 25 boys (12‐18 years). The FVIII levels were taken at 3, 24, 48, and 72 hours following a dose of either FVIII; levels analyzed by WAPPS PK program. The PK profiles (half‐life, clearance, an...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2019-07, Vol.17 (7), p.1085-1096
Hauptverfasser:	Carcao, Manuel D., Chelle, Pierre, Clarke, Emily, Kim, Lussia, Tiseo, Laura, Morfini, Massimo, Hossain, Taneya, Rand, Margaret L., Brown, Christine, Edginton, Andrea N., Lillicrap, David, Iorio, Alfonso, Blanchette, Victor S.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABO Blood-Group System Adolescent Adolescents Blood groups Child Coagulation factors comparative Drug Substitution extended half‐life Factor VIII - administration & dosage Factor VIII - pharmacokinetics Factor VIII deficiency Half-Life Hemophilia Hemophilia A - blood Hemophilia A - diagnosis Hemophilia A - drug therapy Hemostatics - administration & dosage Hemostatics - pharmacokinetics Humans Immunoglobulin Fc Fragments - administration & dosage Male Metabolic Clearance Rate Ontario Pharmacokinetics Prophylaxis Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - pharmacokinetics Severity of Illness Index Von Willebrand factor von Willebrand Factor - metabolism
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