305-LB: BRD7 Deficiency Leads to the Development of Obesity

Elevated endoplasmic reticulum (ER) stress is tightly associated with the development of obesity and insulin resistance. Previous reports showed that haploinsufficiency of X-box binding protein 1 (XBP1), one of the master regulators of ER protein folding function, results in obesity and type 2 diabe...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2019-06, Vol.68 (Supplement_1)
Hauptverfasser:	LEE, JUNSIK M., KIM, YOO, SALAZAR HERNANDEZ, MARIO A., PARK, SANG
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activating transcription factor 1 Body weight gain Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Endoplasmic reticulum Glucose tolerance Haploinsufficiency High fat diet Homeostasis Insulin Insulin resistance Intolerance Kinases Liver Nuclear transport Obesity Protein folding Proteins Regulatory subunits
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