195-OR: The P66Shc Protein Mediates Insulin Resistance in Pancreatic β Cells Under Lipotoxic Conditions

Insulin, acting in an autocrine manner, promotes β-cell survival and growth and its own biosynthesis and secretion. Prolonged exposure of β-cells to high levels of saturated fatty acids (SFAs) impairs insulin signaling, reducing the ability of insulin to promote its release. The p66Shc protein is an...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2019-06, Vol.68
Hauptverfasser:	Dipaola, Lucia, Natalicchio, Annalisa, Biondi, Giuseppina, Marrano, Nicola, Bugliani, Marco, Cignarelli, Angelo, Perrini, Sebastio, Marchetti, Piero, Laviola, Luigi, Dipaola, Francesco Giorginolucia, Giorgino, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Apoptosis Autocrine signalling Beta cells Biosynthesis Body fat Body weight Cell survival Fatty acids Glucose Insulin Insulin receptor substrate 1 Insulin resistance mRNA Obesity Overweight Oxidative stress Palmitic acid Pancreas Peptides Phosphorylation Proteins Secretion
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