Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome
Objective The usefulness of positron emission tomography–computed tomography (PET‐CT) with 18F‐labeled fluorodeoxyglucose (18F‐FDG) for the diagnosis of lymphoma in patients with primary Sjögren's syndrome (SS) is unclear, since the abnormalities it reveals may be due to systemic manifestations...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2019-07, Vol.71 (7), p.1147-1157 |
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| creator | Keraen, Jérémy Blanc, Estelle Besson, Florent L. Leguern, Véronique Meyer, Céline Henry, Julien Belkhir, Rakiba Nocturne, Gaétane Mariette, Xavier Seror, Raphaèle |
| description | Objective
The usefulness of positron emission tomography–computed tomography (PET‐CT) with 18F‐labeled fluorodeoxyglucose (18F‐FDG) for the diagnosis of lymphoma in patients with primary Sjögren's syndrome (SS) is unclear, since the abnormalities it reveals may be due to systemic manifestations of SS. This study was undertaken to compare 18F‐FDG–PET‐CT in patients with primary SS with lymphoma and those without lymphoma in order to identify patterns associated with lymphoma.
Methods
A retrospective study was conducted in 2 centers and included patients who met the American College of Rheumatology/European League Against Rheumatism 2016 criteria for primary SS and had undergone PET‐CT. Two independent readers who were blinded with regard to lymphoma diagnosis analyzed PET‐CT scans. Abnormalities were compared between patients with and those without lymphoma.
Results
Of the 45 patients included, 15 had lymphoma. Compared to patients without lymphoma, the mean size (P = 0.048) and maximum standardized uptake value (SUVmax) (P = 0.001) of the parotid glands were higher in patients with lymphoma. FDG uptake in the lymph nodes was observed in 53.3% of the patients with lymphoma and 43.3% of the patients without lymphoma, with no difference in the number of sites, uptake pattern, or mean SUVmax. Focal pulmonary uptake (nodules or condensations) was observed in 5 of the patients with lymphoma (33.3%) but only 1 patient without lymphoma (3.3%) (P = 0.01). Having an SUVmax in the parotid gland of ≥4.7 and/or the presence of focal pulmonary lesions was highly suggestive of lymphoma (sensitivity 80%, specificity 83.3%).
Conclusion
Some systemic manifestations of primary SS (lymphadenopathy, pulmonary involvement, and salivary gland involvement) can be visualized by PET‐CT. Involvement of the lymph nodes and parotid glands is commonly observed with a similar frequency in SS patients with and those without lymphoma. An SUVmax in the parotid glands of ≥4.7 and/or the presence of focal lung lesions are associated with the diagnosis of lymphoma. |
| doi_str_mv | 10.1002/art.40829 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_journals_2246976379</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2246976379</sourcerecordid><originalsourceid>FETCH-LOGICAL-p689-ca2135cc348b5b3a2db70e2c16aa1ab1b292461a9f22f196cf98c6a5a46c96883</originalsourceid><addsrcrecordid>eNo1kLFOwzAURS0EEhV04A8sMTCltZ3EiceqtIAUiYqG2XIcJ02VxMFOBNk6MyHxL_wAf9IvIbTwlneH8-67ugBcYTTBCJGpMO3EQyFhJ2BEXEIdnyD_9F9jhs_B2NotGoYFiCJ_BN6frcq6slbWQp1BHC73u49IJKpUKVyWnTY6Vfqtz8tOaqv2u8-VtkVrdA0XVWFtMYhYVzo3otn0MNMGthsFbwuR1wN4MI36qtnoSsCihitTVML0cL39_sqNqm8sXPd1anSlLsFZJkqrxn_7AsTLRTy_d6LHu4f5LHIaGjJHCoJdX0rXCxM_cQVJkwApIjEVAosEJ4QRj2LBMkIyzKjMWCip8IVHJaNh6F6A66NtY_RLp2zLt7oz9fCRk-GSBdQN2EBNj9RrUaqeN8fYHCP-2zQfmuaHpvnsKT4I9wdMmHfT</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2246976379</pqid></control><display><type>article</type><title>Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome</title><source>Wiley Journals</source><source>Alma/SFX Local Collection</source><creator>Keraen, Jérémy ; Blanc, Estelle ; Besson, Florent L. ; Leguern, Véronique ; Meyer, Céline ; Henry, Julien ; Belkhir, Rakiba ; Nocturne, Gaétane ; Mariette, Xavier ; Seror, Raphaèle</creator><creatorcontrib>Keraen, Jérémy ; Blanc, Estelle ; Besson, Florent L. ; Leguern, Véronique ; Meyer, Céline ; Henry, Julien ; Belkhir, Rakiba ; Nocturne, Gaétane ; Mariette, Xavier ; Seror, Raphaèle</creatorcontrib><description>Objective
The usefulness of positron emission tomography–computed tomography (PET‐CT) with 18F‐labeled fluorodeoxyglucose (18F‐FDG) for the diagnosis of lymphoma in patients with primary Sjögren's syndrome (SS) is unclear, since the abnormalities it reveals may be due to systemic manifestations of SS. This study was undertaken to compare 18F‐FDG–PET‐CT in patients with primary SS with lymphoma and those without lymphoma in order to identify patterns associated with lymphoma.
Methods
A retrospective study was conducted in 2 centers and included patients who met the American College of Rheumatology/European League Against Rheumatism 2016 criteria for primary SS and had undergone PET‐CT. Two independent readers who were blinded with regard to lymphoma diagnosis analyzed PET‐CT scans. Abnormalities were compared between patients with and those without lymphoma.
Results
Of the 45 patients included, 15 had lymphoma. Compared to patients without lymphoma, the mean size (P = 0.048) and maximum standardized uptake value (SUVmax) (P = 0.001) of the parotid glands were higher in patients with lymphoma. FDG uptake in the lymph nodes was observed in 53.3% of the patients with lymphoma and 43.3% of the patients without lymphoma, with no difference in the number of sites, uptake pattern, or mean SUVmax. Focal pulmonary uptake (nodules or condensations) was observed in 5 of the patients with lymphoma (33.3%) but only 1 patient without lymphoma (3.3%) (P = 0.01). Having an SUVmax in the parotid gland of ≥4.7 and/or the presence of focal pulmonary lesions was highly suggestive of lymphoma (sensitivity 80%, specificity 83.3%).
Conclusion
Some systemic manifestations of primary SS (lymphadenopathy, pulmonary involvement, and salivary gland involvement) can be visualized by PET‐CT. Involvement of the lymph nodes and parotid glands is commonly observed with a similar frequency in SS patients with and those without lymphoma. An SUVmax in the parotid glands of ≥4.7 and/or the presence of focal lung lesions are associated with the diagnosis of lymphoma.</description><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.40829</identifier><language>eng</language><publisher>Atlanta: Wiley Subscription Services, Inc</publisher><subject>Abnormalities ; Computed tomography ; Diagnosis ; Fluorine isotopes ; Identification methods ; Lung nodules ; Lymph nodes ; Lymphadenopathy ; Lymphatic system ; Lymphoma ; Nodes ; Nodules ; Parotid gland ; Positron emission ; Positron emission tomography ; Pulmonary lesions ; Salivary gland ; Salivary glands ; Sjogren's syndrome ; Tomography</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2019-07, Vol.71 (7), p.1147-1157</ispartof><rights>2019, American College of Rheumatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.40829$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.40829$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Keraen, Jérémy</creatorcontrib><creatorcontrib>Blanc, Estelle</creatorcontrib><creatorcontrib>Besson, Florent L.</creatorcontrib><creatorcontrib>Leguern, Véronique</creatorcontrib><creatorcontrib>Meyer, Céline</creatorcontrib><creatorcontrib>Henry, Julien</creatorcontrib><creatorcontrib>Belkhir, Rakiba</creatorcontrib><creatorcontrib>Nocturne, Gaétane</creatorcontrib><creatorcontrib>Mariette, Xavier</creatorcontrib><creatorcontrib>Seror, Raphaèle</creatorcontrib><title>Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><description>Objective
The usefulness of positron emission tomography–computed tomography (PET‐CT) with 18F‐labeled fluorodeoxyglucose (18F‐FDG) for the diagnosis of lymphoma in patients with primary Sjögren's syndrome (SS) is unclear, since the abnormalities it reveals may be due to systemic manifestations of SS. This study was undertaken to compare 18F‐FDG–PET‐CT in patients with primary SS with lymphoma and those without lymphoma in order to identify patterns associated with lymphoma.
Methods
A retrospective study was conducted in 2 centers and included patients who met the American College of Rheumatology/European League Against Rheumatism 2016 criteria for primary SS and had undergone PET‐CT. Two independent readers who were blinded with regard to lymphoma diagnosis analyzed PET‐CT scans. Abnormalities were compared between patients with and those without lymphoma.
Results
Of the 45 patients included, 15 had lymphoma. Compared to patients without lymphoma, the mean size (P = 0.048) and maximum standardized uptake value (SUVmax) (P = 0.001) of the parotid glands were higher in patients with lymphoma. FDG uptake in the lymph nodes was observed in 53.3% of the patients with lymphoma and 43.3% of the patients without lymphoma, with no difference in the number of sites, uptake pattern, or mean SUVmax. Focal pulmonary uptake (nodules or condensations) was observed in 5 of the patients with lymphoma (33.3%) but only 1 patient without lymphoma (3.3%) (P = 0.01). Having an SUVmax in the parotid gland of ≥4.7 and/or the presence of focal pulmonary lesions was highly suggestive of lymphoma (sensitivity 80%, specificity 83.3%).
Conclusion
Some systemic manifestations of primary SS (lymphadenopathy, pulmonary involvement, and salivary gland involvement) can be visualized by PET‐CT. Involvement of the lymph nodes and parotid glands is commonly observed with a similar frequency in SS patients with and those without lymphoma. An SUVmax in the parotid glands of ≥4.7 and/or the presence of focal lung lesions are associated with the diagnosis of lymphoma.</description><subject>Abnormalities</subject><subject>Computed tomography</subject><subject>Diagnosis</subject><subject>Fluorine isotopes</subject><subject>Identification methods</subject><subject>Lung nodules</subject><subject>Lymph nodes</subject><subject>Lymphadenopathy</subject><subject>Lymphatic system</subject><subject>Lymphoma</subject><subject>Nodes</subject><subject>Nodules</subject><subject>Parotid gland</subject><subject>Positron emission</subject><subject>Positron emission tomography</subject><subject>Pulmonary lesions</subject><subject>Salivary gland</subject><subject>Salivary glands</subject><subject>Sjogren's syndrome</subject><subject>Tomography</subject><issn>2326-5191</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNo1kLFOwzAURS0EEhV04A8sMTCltZ3EiceqtIAUiYqG2XIcJ02VxMFOBNk6MyHxL_wAf9IvIbTwlneH8-67ugBcYTTBCJGpMO3EQyFhJ2BEXEIdnyD_9F9jhs_B2NotGoYFiCJ_BN6frcq6slbWQp1BHC73u49IJKpUKVyWnTY6Vfqtz8tOaqv2u8-VtkVrdA0XVWFtMYhYVzo3otn0MNMGthsFbwuR1wN4MI36qtnoSsCihitTVML0cL39_sqNqm8sXPd1anSlLsFZJkqrxn_7AsTLRTy_d6LHu4f5LHIaGjJHCoJdX0rXCxM_cQVJkwApIjEVAosEJ4QRj2LBMkIyzKjMWCip8IVHJaNh6F6A66NtY_RLp2zLt7oz9fCRk-GSBdQN2EBNj9RrUaqeN8fYHCP-2zQfmuaHpvnsKT4I9wdMmHfT</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Keraen, Jérémy</creator><creator>Blanc, Estelle</creator><creator>Besson, Florent L.</creator><creator>Leguern, Véronique</creator><creator>Meyer, Céline</creator><creator>Henry, Julien</creator><creator>Belkhir, Rakiba</creator><creator>Nocturne, Gaétane</creator><creator>Mariette, Xavier</creator><creator>Seror, Raphaèle</creator><general>Wiley Subscription Services, Inc</general><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>201907</creationdate><title>Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome</title><author>Keraen, Jérémy ; Blanc, Estelle ; Besson, Florent L. ; Leguern, Véronique ; Meyer, Céline ; Henry, Julien ; Belkhir, Rakiba ; Nocturne, Gaétane ; Mariette, Xavier ; Seror, Raphaèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p689-ca2135cc348b5b3a2db70e2c16aa1ab1b292461a9f22f196cf98c6a5a46c96883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Abnormalities</topic><topic>Computed tomography</topic><topic>Diagnosis</topic><topic>Fluorine isotopes</topic><topic>Identification methods</topic><topic>Lung nodules</topic><topic>Lymph nodes</topic><topic>Lymphadenopathy</topic><topic>Lymphatic system</topic><topic>Lymphoma</topic><topic>Nodes</topic><topic>Nodules</topic><topic>Parotid gland</topic><topic>Positron emission</topic><topic>Positron emission tomography</topic><topic>Pulmonary lesions</topic><topic>Salivary gland</topic><topic>Salivary glands</topic><topic>Sjogren's syndrome</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keraen, Jérémy</creatorcontrib><creatorcontrib>Blanc, Estelle</creatorcontrib><creatorcontrib>Besson, Florent L.</creatorcontrib><creatorcontrib>Leguern, Véronique</creatorcontrib><creatorcontrib>Meyer, Céline</creatorcontrib><creatorcontrib>Henry, Julien</creatorcontrib><creatorcontrib>Belkhir, Rakiba</creatorcontrib><creatorcontrib>Nocturne, Gaétane</creatorcontrib><creatorcontrib>Mariette, Xavier</creatorcontrib><creatorcontrib>Seror, Raphaèle</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keraen, Jérémy</au><au>Blanc, Estelle</au><au>Besson, Florent L.</au><au>Leguern, Véronique</au><au>Meyer, Céline</au><au>Henry, Julien</au><au>Belkhir, Rakiba</au><au>Nocturne, Gaétane</au><au>Mariette, Xavier</au><au>Seror, Raphaèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><date>2019-07</date><risdate>2019</risdate><volume>71</volume><issue>7</issue><spage>1147</spage><epage>1157</epage><pages>1147-1157</pages><issn>2326-5191</issn><eissn>2326-5205</eissn><abstract>Objective
The usefulness of positron emission tomography–computed tomography (PET‐CT) with 18F‐labeled fluorodeoxyglucose (18F‐FDG) for the diagnosis of lymphoma in patients with primary Sjögren's syndrome (SS) is unclear, since the abnormalities it reveals may be due to systemic manifestations of SS. This study was undertaken to compare 18F‐FDG–PET‐CT in patients with primary SS with lymphoma and those without lymphoma in order to identify patterns associated with lymphoma.
Methods
A retrospective study was conducted in 2 centers and included patients who met the American College of Rheumatology/European League Against Rheumatism 2016 criteria for primary SS and had undergone PET‐CT. Two independent readers who were blinded with regard to lymphoma diagnosis analyzed PET‐CT scans. Abnormalities were compared between patients with and those without lymphoma.
Results
Of the 45 patients included, 15 had lymphoma. Compared to patients without lymphoma, the mean size (P = 0.048) and maximum standardized uptake value (SUVmax) (P = 0.001) of the parotid glands were higher in patients with lymphoma. FDG uptake in the lymph nodes was observed in 53.3% of the patients with lymphoma and 43.3% of the patients without lymphoma, with no difference in the number of sites, uptake pattern, or mean SUVmax. Focal pulmonary uptake (nodules or condensations) was observed in 5 of the patients with lymphoma (33.3%) but only 1 patient without lymphoma (3.3%) (P = 0.01). Having an SUVmax in the parotid gland of ≥4.7 and/or the presence of focal pulmonary lesions was highly suggestive of lymphoma (sensitivity 80%, specificity 83.3%).
Conclusion
Some systemic manifestations of primary SS (lymphadenopathy, pulmonary involvement, and salivary gland involvement) can be visualized by PET‐CT. Involvement of the lymph nodes and parotid glands is commonly observed with a similar frequency in SS patients with and those without lymphoma. An SUVmax in the parotid glands of ≥4.7 and/or the presence of focal lung lesions are associated with the diagnosis of lymphoma.</abstract><cop>Atlanta</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/art.40829</doi><tpages>11</tpages></addata></record> |
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| ispartof | Arthritis & rheumatology (Hoboken, N.J.), 2019-07, Vol.71 (7), p.1147-1157 |
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| source | Wiley Journals; Alma/SFX Local Collection |
| subjects | Abnormalities Computed tomography Diagnosis Fluorine isotopes Identification methods Lung nodules Lymph nodes Lymphadenopathy Lymphatic system Lymphoma Nodes Nodules Parotid gland Positron emission Positron emission tomography Pulmonary lesions Salivary gland Salivary glands Sjogren's syndrome Tomography |
| title | Usefulness of 18F‐Labeled Fluorodeoxyglucose–Positron Emission Tomography for the Diagnosis of Lymphoma in Primary Sjögren's Syndrome |
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