Effect of Ketanserin Administration on Intraocular Pressure
Purpose: We evaluated the effect of oral single-dose (20 mg) ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes. Methods: This study included 15 healthy volunteers and 16 patients with ocular hypertension. Systolic blood pressure (SBP), diastolic blood pressure (DBP), hea...
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| Veröffentlicht in: | Ophthalmologica (Basel) 2001-11, Vol.215 (6), p.419-423 |
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| creator | Tekat, Düriye Güler, Cenap Arici, Mustafa Kemal Topalkara, Ayşen Erdoğan, Haydar |
| description | Purpose: We evaluated the effect of oral single-dose (20 mg) ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes. Methods: This study included 15 healthy volunteers and 16 patients with ocular hypertension. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, IOP and pupil diameter were recorded at baseline and at 1-hour intervals for 6 h, in addition, tonographic outflow facility was studied at the third hour after the administration of placebo or an oral single dose of 20 mg ketanserin given in a randomized double-blind crossover fashion. The alternative treatment was applied a week later. Results: In both groups, oral single-dose (20 mg) ketanserin significantly lowered IOP and SBP (p < 0.01). No variation was observed in DBP, heart rate and pupil diameter (p >0.01). Moreover, after drug administration, the total outflow facility measured by conventional tonography increased in a statistically significant way (p < 0.01). Placebo did not induce any significant reduction in IOP and SBP in either group. Conclusion: The results showed that systemic ketanserin can be used in the treatment of glaucoma patients to reduce IOP. |
| doi_str_mv | 10.1159/000050901 |
| format | Article |
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Methods: This study included 15 healthy volunteers and 16 patients with ocular hypertension. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, IOP and pupil diameter were recorded at baseline and at 1-hour intervals for 6 h, in addition, tonographic outflow facility was studied at the third hour after the administration of placebo or an oral single dose of 20 mg ketanserin given in a randomized double-blind crossover fashion. The alternative treatment was applied a week later. Results: In both groups, oral single-dose (20 mg) ketanserin significantly lowered IOP and SBP (p < 0.01). No variation was observed in DBP, heart rate and pupil diameter (p >0.01). Moreover, after drug administration, the total outflow facility measured by conventional tonography increased in a statistically significant way (p < 0.01). Placebo did not induce any significant reduction in IOP and SBP in either group. Conclusion: The results showed that systemic ketanserin can be used in the treatment of glaucoma patients to reduce IOP.</description><identifier>ISSN: 0030-3755</identifier><identifier>EISSN: 1423-0267</identifier><identifier>DOI: 10.1159/000050901</identifier><identifier>PMID: 11741108</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Administration, Oral ; Adult ; Aged ; Biological and medical sciences ; Blood Pressure - drug effects ; Cross-Over Studies ; Double-Blind Method ; Drug Evaluation ; Eye ; Female ; Glaucoma, Open-Angle - drug therapy ; Heart Rate - drug effects ; Humans ; Intraocular Pressure - drug effects ; Ketanserin - administration & dosage ; Male ; Medical sciences ; Middle Aged ; Ocular Hypertension - drug therapy ; Original Paper · Travail original · Originalarbeit ; Pharmacology. 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Methods: This study included 15 healthy volunteers and 16 patients with ocular hypertension. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, IOP and pupil diameter were recorded at baseline and at 1-hour intervals for 6 h, in addition, tonographic outflow facility was studied at the third hour after the administration of placebo or an oral single dose of 20 mg ketanserin given in a randomized double-blind crossover fashion. The alternative treatment was applied a week later. Results: In both groups, oral single-dose (20 mg) ketanserin significantly lowered IOP and SBP (p < 0.01). No variation was observed in DBP, heart rate and pupil diameter (p >0.01). Moreover, after drug administration, the total outflow facility measured by conventional tonography increased in a statistically significant way (p < 0.01). Placebo did not induce any significant reduction in IOP and SBP in either group. Conclusion: The results showed that systemic ketanserin can be used in the treatment of glaucoma patients to reduce IOP.</description><subject>Administration, Oral</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cross-Over Studies</subject><subject>Double-Blind Method</subject><subject>Drug Evaluation</subject><subject>Eye</subject><subject>Female</subject><subject>Glaucoma, Open-Angle - drug therapy</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Intraocular Pressure - drug effects</subject><subject>Ketanserin - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ocular Hypertension - drug therapy</subject><subject>Original Paper · Travail original · Originalarbeit</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Pupil - drug effects</topic><topic>Serotonin Antagonists - administration & dosage</topic><topic>Tonometry, Ocular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tekat, Düriye</creatorcontrib><creatorcontrib>Güler, Cenap</creatorcontrib><creatorcontrib>Arici, Mustafa Kemal</creatorcontrib><creatorcontrib>Topalkara, Ayşen</creatorcontrib><creatorcontrib>Erdoğan, Haydar</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmologica (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tekat, Düriye</au><au>Güler, Cenap</au><au>Arici, Mustafa Kemal</au><au>Topalkara, Ayşen</au><au>Erdoğan, Haydar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Ketanserin Administration on Intraocular Pressure</atitle><jtitle>Ophthalmologica (Basel)</jtitle><addtitle>Ophthalmologica</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>215</volume><issue>6</issue><spage>419</spage><epage>423</epage><pages>419-423</pages><issn>0030-3755</issn><eissn>1423-0267</eissn><abstract>Purpose: We evaluated the effect of oral single-dose (20 mg) ketanserin on intraocular pressure (IOP) in normotensive and hypertensive eyes. Methods: This study included 15 healthy volunteers and 16 patients with ocular hypertension. Systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate, IOP and pupil diameter were recorded at baseline and at 1-hour intervals for 6 h, in addition, tonographic outflow facility was studied at the third hour after the administration of placebo or an oral single dose of 20 mg ketanserin given in a randomized double-blind crossover fashion. The alternative treatment was applied a week later. Results: In both groups, oral single-dose (20 mg) ketanserin significantly lowered IOP and SBP (p < 0.01). No variation was observed in DBP, heart rate and pupil diameter (p >0.01). Moreover, after drug administration, the total outflow facility measured by conventional tonography increased in a statistically significant way (p < 0.01). Placebo did not induce any significant reduction in IOP and SBP in either group. Conclusion: The results showed that systemic ketanserin can be used in the treatment of glaucoma patients to reduce IOP.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11741108</pmid><doi>10.1159/000050901</doi><tpages>5</tpages></addata></record> |
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| subjects | Administration, Oral Adult Aged Biological and medical sciences Blood Pressure - drug effects Cross-Over Studies Double-Blind Method Drug Evaluation Eye Female Glaucoma, Open-Angle - drug therapy Heart Rate - drug effects Humans Intraocular Pressure - drug effects Ketanserin - administration & dosage Male Medical sciences Middle Aged Ocular Hypertension - drug therapy Original Paper · Travail original · Originalarbeit Pharmacology. Drug treatments Pupil - drug effects Serotonin Antagonists - administration & dosage Tonometry, Ocular |
| title | Effect of Ketanserin Administration on Intraocular Pressure |
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