Changing Antiglaucoma Therapy from Timolol to Betaxolol: Effect on Ocular Blood Flow
The aim of the present study was to investigate the effect of a therapy change from timolol to betaxolol on ocular blood flow in patients with open-angle glaucoma. This randomized double-blind study comprised 34 consecutive patients with open-angle glaucoma, already treated with either timolol alone...
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| Veröffentlicht in: | Ophthalmologica (Basel) 2003-07, Vol.217 (4), p.288-293 |
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| creator | Rainer, Georg Dorner, Guido T. Garhöfer, Gerhard Vass, Clemens Pfleger, Thomas Schmetterer, Leopold |
| description | The aim of the present study was to investigate the effect of a therapy change from timolol to betaxolol on ocular blood flow in patients with open-angle glaucoma. This randomized double-blind study comprised 34 consecutive patients with open-angle glaucoma, already treated with either timolol alone or in combination with other antiglaucoma agents. The patients were randomly allocated to receive either betaxolol (n = 17) or timolol (n = 17) instead of the present timolol drops. Additional antiglaucoma therapy remained unchanged. The retinal blood flow was assessed by scanning laser Doppler flowmetry and the pulsatile choroidal blood flow was assessed by laser interferometric measurement of fundus pulsation amplitude. Ocular blood flow measurement as well as systemic hemodynamic and intraocular pressure (IOP) measurements were performed at baseline and 1 week and 1 and 3 months after the therapy change. Visual field testing was performed at baseline and at 3 months. After 3 months of treatment with either timolol or betaxolol, neither the retinal nor the pulsatile choroidal blood flow were significantly altered. The power to detect a 9% change in pulsatile choroidal blood flow and a 20% change in retinal blood flow in the present study was 90%. The IOP was not significantly altered in either group. In contrast, visual fields slightly improved after betaxolol treatment compared to baseline (p = 0.047), but this effect was not significant versus timolol. Changing therapy from timolol to betaxolol has no effect on ocular blood flow in patients with open-angle glaucoma. |
| doi_str_mv | 10.1159/000070637 |
| format | Article |
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This randomized double-blind study comprised 34 consecutive patients with open-angle glaucoma, already treated with either timolol alone or in combination with other antiglaucoma agents. The patients were randomly allocated to receive either betaxolol (n = 17) or timolol (n = 17) instead of the present timolol drops. Additional antiglaucoma therapy remained unchanged. The retinal blood flow was assessed by scanning laser Doppler flowmetry and the pulsatile choroidal blood flow was assessed by laser interferometric measurement of fundus pulsation amplitude. Ocular blood flow measurement as well as systemic hemodynamic and intraocular pressure (IOP) measurements were performed at baseline and 1 week and 1 and 3 months after the therapy change. Visual field testing was performed at baseline and at 3 months. After 3 months of treatment with either timolol or betaxolol, neither the retinal nor the pulsatile choroidal blood flow were significantly altered. The power to detect a 9% change in pulsatile choroidal blood flow and a 20% change in retinal blood flow in the present study was 90%. The IOP was not significantly altered in either group. In contrast, visual fields slightly improved after betaxolol treatment compared to baseline (p = 0.047), but this effect was not significant versus timolol. Changing therapy from timolol to betaxolol has no effect on ocular blood flow in patients with open-angle glaucoma.</description><identifier>ISSN: 0030-3755</identifier><identifier>EISSN: 1423-0267</identifier><identifier>DOI: 10.1159/000070637</identifier><identifier>PMID: 12792136</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adolescent ; Adrenergic beta-Antagonists - therapeutic use ; Adult ; Aged ; Aged, 80 and over ; Betaxolol - therapeutic use ; Biological and medical sciences ; Child ; Child, Preschool ; Double-Blind Method ; Eye ; Eye - blood supply ; Female ; Glaucoma - drug therapy ; Glaucoma - physiopathology ; Hemodynamics - drug effects ; Humans ; Intraocular Pressure - drug effects ; Male ; Medical sciences ; Middle Aged ; Original Paper ; Pharmacology. Drug treatments ; Regional Blood Flow - drug effects ; Timolol - therapeutic use ; Visual Fields - drug effects</subject><ispartof>Ophthalmologica (Basel), 2003-07, Vol.217 (4), p.288-293</ispartof><rights>2003 S. Karger AG, Basel</rights><rights>2003 INIST-CNRS</rights><rights>Copyright 2003 S. Karger AG, Basel</rights><rights>Copyright (c) 2003 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-da62518e23c97e0238b95dd719cca0ced30b65df805e47fa28de99f4073653243</citedby><cites>FETCH-LOGICAL-c385t-da62518e23c97e0238b95dd719cca0ced30b65df805e47fa28de99f4073653243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,2433,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14862147$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12792136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rainer, Georg</creatorcontrib><creatorcontrib>Dorner, Guido T.</creatorcontrib><creatorcontrib>Garhöfer, Gerhard</creatorcontrib><creatorcontrib>Vass, Clemens</creatorcontrib><creatorcontrib>Pfleger, Thomas</creatorcontrib><creatorcontrib>Schmetterer, Leopold</creatorcontrib><title>Changing Antiglaucoma Therapy from Timolol to Betaxolol: Effect on Ocular Blood Flow</title><title>Ophthalmologica (Basel)</title><addtitle>Ophthalmologica</addtitle><description>The aim of the present study was to investigate the effect of a therapy change from timolol to betaxolol on ocular blood flow in patients with open-angle glaucoma. This randomized double-blind study comprised 34 consecutive patients with open-angle glaucoma, already treated with either timolol alone or in combination with other antiglaucoma agents. The patients were randomly allocated to receive either betaxolol (n = 17) or timolol (n = 17) instead of the present timolol drops. Additional antiglaucoma therapy remained unchanged. The retinal blood flow was assessed by scanning laser Doppler flowmetry and the pulsatile choroidal blood flow was assessed by laser interferometric measurement of fundus pulsation amplitude. Ocular blood flow measurement as well as systemic hemodynamic and intraocular pressure (IOP) measurements were performed at baseline and 1 week and 1 and 3 months after the therapy change. Visual field testing was performed at baseline and at 3 months. After 3 months of treatment with either timolol or betaxolol, neither the retinal nor the pulsatile choroidal blood flow were significantly altered. The power to detect a 9% change in pulsatile choroidal blood flow and a 20% change in retinal blood flow in the present study was 90%. The IOP was not significantly altered in either group. In contrast, visual fields slightly improved after betaxolol treatment compared to baseline (p = 0.047), but this effect was not significant versus timolol. Changing therapy from timolol to betaxolol has no effect on ocular blood flow in patients with open-angle glaucoma.</description><subject>Adolescent</subject><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Betaxolol - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Double-Blind Method</subject><subject>Eye</subject><subject>Eye - blood supply</subject><subject>Female</subject><subject>Glaucoma - drug therapy</subject><subject>Glaucoma - physiopathology</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Intraocular Pressure - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Regional Blood Flow - drug effects</topic><topic>Timolol - therapeutic use</topic><topic>Visual Fields - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rainer, Georg</creatorcontrib><creatorcontrib>Dorner, Guido T.</creatorcontrib><creatorcontrib>Garhöfer, Gerhard</creatorcontrib><creatorcontrib>Vass, Clemens</creatorcontrib><creatorcontrib>Pfleger, Thomas</creatorcontrib><creatorcontrib>Schmetterer, Leopold</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmologica (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rainer, Georg</au><au>Dorner, Guido T.</au><au>Garhöfer, Gerhard</au><au>Vass, Clemens</au><au>Pfleger, Thomas</au><au>Schmetterer, Leopold</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing Antiglaucoma Therapy from Timolol to Betaxolol: Effect on Ocular Blood Flow</atitle><jtitle>Ophthalmologica (Basel)</jtitle><addtitle>Ophthalmologica</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>217</volume><issue>4</issue><spage>288</spage><epage>293</epage><pages>288-293</pages><issn>0030-3755</issn><eissn>1423-0267</eissn><abstract>The aim of the present study was to investigate the effect of a therapy change from timolol to betaxolol on ocular blood flow in patients with open-angle glaucoma. This randomized double-blind study comprised 34 consecutive patients with open-angle glaucoma, already treated with either timolol alone or in combination with other antiglaucoma agents. The patients were randomly allocated to receive either betaxolol (n = 17) or timolol (n = 17) instead of the present timolol drops. Additional antiglaucoma therapy remained unchanged. The retinal blood flow was assessed by scanning laser Doppler flowmetry and the pulsatile choroidal blood flow was assessed by laser interferometric measurement of fundus pulsation amplitude. Ocular blood flow measurement as well as systemic hemodynamic and intraocular pressure (IOP) measurements were performed at baseline and 1 week and 1 and 3 months after the therapy change. Visual field testing was performed at baseline and at 3 months. After 3 months of treatment with either timolol or betaxolol, neither the retinal nor the pulsatile choroidal blood flow were significantly altered. The power to detect a 9% change in pulsatile choroidal blood flow and a 20% change in retinal blood flow in the present study was 90%. The IOP was not significantly altered in either group. In contrast, visual fields slightly improved after betaxolol treatment compared to baseline (p = 0.047), but this effect was not significant versus timolol. Changing therapy from timolol to betaxolol has no effect on ocular blood flow in patients with open-angle glaucoma.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>12792136</pmid><doi>10.1159/000070637</doi><tpages>6</tpages></addata></record> |
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| subjects | Adolescent Adrenergic beta-Antagonists - therapeutic use Adult Aged Aged, 80 and over Betaxolol - therapeutic use Biological and medical sciences Child Child, Preschool Double-Blind Method Eye Eye - blood supply Female Glaucoma - drug therapy Glaucoma - physiopathology Hemodynamics - drug effects Humans Intraocular Pressure - drug effects Male Medical sciences Middle Aged Original Paper Pharmacology. Drug treatments Regional Blood Flow - drug effects Timolol - therapeutic use Visual Fields - drug effects |
| title | Changing Antiglaucoma Therapy from Timolol to Betaxolol: Effect on Ocular Blood Flow |
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