Involvement of Retinal Neurons and Pigment Epithelial Cells in a Murine Model of Sandhoff Disease

Background/Aims: To investigate the effects of deficient degradation of glycolipids on the morphological appearance of all retinal cells in a murine model of G M2 gangliosidosis (Sandhoff disease). Methods: The morphological appearance of the retina in Sandhoff mice at symptomatic stages (3 and 4 mo...

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Veröffentlicht in:	Ophthalmic research 2008-01, Vol.40 (5), p.241-248
Hauptverfasser:	Sango, Kazunori, Yamanaka, Shoji, Ajiki, Kyoko, Arai, Nobutaka, Takano, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal G(M2) Ganglioside - metabolism Immunoenzyme Techniques Mice Microscopy, Immunoelectron Neurons, Afferent - metabolism Neurons, Afferent - ultrastructure Original Paper Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - ultrastructure Retina - ultrastructure Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - ultrastructure Sandhoff Disease - pathology
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