Nitric Oxide as a Second Messenger in Phagocytosis by Cultured Retinal Pigment Epithelial Cells

Purpose: To investigate a possible role of the nitric oxide (NO)-cGMP signal transduction system in phagocytosis of rod outer segments (ROS) by cultured retinal pigment epithelial (RPE) cells. Methods: Primary cultures of RPE cells from 10-day-old Brown Norway rats were used to study the phagocytosi...

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Veröffentlicht in:	Ophthalmic research 2000-07, Vol.32 (4), p.138-142
Hauptverfasser:	Kogishi, Jun-ichi, Akimoto, Masayuki, Mandai, Michiko, Kuriyama, Shoji, Hall, Michael O., Honda, Yoshihito, Yoshimura, Nagahisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cyclic GMP - metabolism Enzyme Inhibitors - pharmacology Molsidomine - analogs & derivatives Molsidomine - pharmacology Nitric Oxide - physiology Nitric Oxide Donors - pharmacology Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type III Nitroarginine - pharmacology Original Paper Phagocytosis - drug effects Phagocytosis - physiology Pigment Epithelium of Eye - cytology Pigment Epithelium of Eye - metabolism Rats Rats, Inbred BN Rod Cell Outer Segment - physiology Second Messenger Systems - physiology
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