Isolation and identification of photoproducts from UVA-irradiated mixture of N-nitrosoproline with 2'-deoxyadenosine

[Display omitted] •UVA-mediated reaction between N-nitrosoproline and 2'-deoxyadenosine.•Identification of three possible adenine modifications.•One already known and two hitherto unknown photoproducts were identified. N-Nitrosoproline (NPRO) is known to form endogenously from sodium nitrite an...

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Veröffentlicht in:	Journal of photochemistry and photobiology. A, Chemistry. Chemistry., 2019-05, Vol.377, p.159-166
Hauptverfasser:	Aoyama, Shuhei, Asahi, Chiharu, Sano, Kayoko, Kimura, Sachiko, Suzuki, Toshinori, Hatano, Tsutomu, Arimoto-Kobayashi, Sakae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Adenine adenosine adducts Amino acids Carcinogens Cations Deoxyadenosine deoxyinosine Deoxyribonucleic acid DNA High-performance liquid chromatography Irradiation Liquid chromatography N-nitrosoproline NMR Nuclear magnetic resonance Organic chemistry Photoproduction photoreaction Proline Reactive oxygen species Saturation Sodium Sodium nitrite Ultraviolet radiation
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