Vardenafil and cilostazol can improve vascular reactivity in rats with diabetes mellitus and rheumatoid arthritis co-morbidity

Endothelial dysfunction and vascular reactivity defects secondary to metabolic and immunological disorders carry risk of serious cardiovascular complications. Here, the effects of the phosphodiesterase (PDE) inhibitors vardenafil and cilostazol were examined against rheumatoid arthritis (RA)/diabete...

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Veröffentlicht in:	Life sciences (1973) 2019-07, Vol.229, p.67-79
Hauptverfasser:	Wahba, Mariam Gamal Fahmy, Messiha, Basim Anwar Shehata, El-Daly, Mahmoud El-Sayed, Abo-Saif, Ali Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Adenosine kinase Adhesion AMP Angiotensin Angiotensin II Animals Aorta Arthritis Arthritis, Experimental - complications Arthritis, Rheumatoid - complications Biomarkers Cardiovascular diseases Cardiovascular Diseases - drug therapy Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cell adhesion Cell adhesion & migration Cell adhesion molecules Cilostazol Cilostazol - pharmacology Comorbidity Complications Contraction Coupling (molecular) Defects Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - complications Endothelial dysfunction Endothelin 1 Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Enzyme-linked immunosorbent assay Female Gelatinase A Health risks Immunology Inflammation Intestine Kinases Matrix metalloproteinase Matrix metalloproteinases Metalloproteinase Morbidity Nitric oxide Nitric-oxide synthase P-selectin Protein kinase Rats Reactivity Rheumatoid arthritis Sodium Vardenafil Vardenafil Dihydrochloride - pharmacology Vascular reactivity Vasoactive agents Vasodilation Vasodilator Agents - pharmacology
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