Association of juvenile idiopathic arhrtitis and functional constipation
The authors present case reports with juvenile idiopathic arthritis being associated with functional constipation but not with inflammatory bowel disease. The cause of megacolon was only cleared in one case in the form of Hirschprung ’s disease. The skeletal symptoms could be classified as seronegat...
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| Veröffentlicht in: | International journal of clinical rheumatology 2009-12, Vol.4 (6), p.673-680 |
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| container_end_page | 680 |
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| container_issue | 6 |
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| container_title | International journal of clinical rheumatology |
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| creator | Bazso, Anna Sevcic, Krisztina Orban, Ilonka Suto, Gabor Poor, Gyula Kiss, Emese Balogh, Zsolt |
| description | The authors present case reports with juvenile idiopathic arthritis being associated with functional constipation but not with inflammatory bowel disease. The cause of megacolon was only cleared in one case in the form of Hirschprung ’s disease. The skeletal symptoms could be classified as seronegative spondylathropathy. Surgical treatment resulted in the remission of arthritis in one case and a possible pathogenic explanation is discussed. Common genetic predisposition is a plausible explanation, but fecal stasis leading to increased permeability to macromolecules, increased exposure to microbial and dietary antigens, loss of tolerance to own bacterial flora and host susceptibility to the increased antigenic load may stand in the background of this infrequent and not yet described association between juvenile idiopathic arthritis and functional constipation. |
| doi_str_mv | 10.2217/ijr.09.60 |
| format | Article |
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The cause of megacolon was only cleared in one case in the form of Hirschprung ’s disease. The skeletal symptoms could be classified as seronegative spondylathropathy. Surgical treatment resulted in the remission of arthritis in one case and a possible pathogenic explanation is discussed. Common genetic predisposition is a plausible explanation, but fecal stasis leading to increased permeability to macromolecules, increased exposure to microbial and dietary antigens, loss of tolerance to own bacterial flora and host susceptibility to the increased antigenic load may stand in the background of this infrequent and not yet described association between juvenile idiopathic arthritis and functional constipation.</description><identifier>ISSN: 1758-4272</identifier><identifier>EISSN: 1758-4280</identifier><identifier>DOI: 10.2217/ijr.09.60</identifier><language>eng</language><publisher>London: Future Medicine Ltd</publisher><subject>Antiarthritic agents ; Arthritis ; bacterial colonization ; Constipation ; Diagnosis ; Drug therapy ; Health aspects ; Hirschprung ’s disease ; JIA ; juvenile idiopathic arthritis ; Permeability ; Risk factors</subject><ispartof>International journal of clinical rheumatology, 2009-12, Vol.4 (6), p.673-680</ispartof><rights>COPYRIGHT 2009 Future Medicine Ltd.</rights><rights>2009 © Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c295t-dd68f759fd2bdf8ba52ff05e7bbe53a3bbd4cd73581622683bb304bd058e38273</citedby><cites>FETCH-LOGICAL-c295t-dd68f759fd2bdf8ba52ff05e7bbe53a3bbd4cd73581622683bb304bd058e38273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>313,314,780,784,792,27921,27923,27924</link.rule.ids></links><search><creatorcontrib>Bazso, Anna</creatorcontrib><creatorcontrib>Sevcic, Krisztina</creatorcontrib><creatorcontrib>Orban, Ilonka</creatorcontrib><creatorcontrib>Suto, Gabor</creatorcontrib><creatorcontrib>Poor, Gyula</creatorcontrib><creatorcontrib>Kiss, Emese</creatorcontrib><creatorcontrib>Balogh, Zsolt</creatorcontrib><title>Association of juvenile idiopathic arhrtitis and functional constipation</title><title>International journal of clinical rheumatology</title><description>The authors present case reports with juvenile idiopathic arthritis being associated with functional constipation but not with inflammatory bowel disease. The cause of megacolon was only cleared in one case in the form of Hirschprung ’s disease. The skeletal symptoms could be classified as seronegative spondylathropathy. Surgical treatment resulted in the remission of arthritis in one case and a possible pathogenic explanation is discussed. Common genetic predisposition is a plausible explanation, but fecal stasis leading to increased permeability to macromolecules, increased exposure to microbial and dietary antigens, loss of tolerance to own bacterial flora and host susceptibility to the increased antigenic load may stand in the background of this infrequent and not yet described association between juvenile idiopathic arthritis and functional constipation.</description><subject>Antiarthritic agents</subject><subject>Arthritis</subject><subject>bacterial colonization</subject><subject>Constipation</subject><subject>Diagnosis</subject><subject>Drug therapy</subject><subject>Health aspects</subject><subject>Hirschprung ’s disease</subject><subject>JIA</subject><subject>juvenile idiopathic arthritis</subject><subject>Permeability</subject><subject>Risk factors</subject><issn>1758-4272</issn><issn>1758-4280</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkTtPwzAQgC0EElXpwD-I2BgSHDt-ZKwqoEiVWGC2HD-oozQutoPEv8cliIkBe7B9-r7T-Q6A6xpWCNXszvWhgm1F4RlY1IzwskEcnv_eGboEqxh7mBeuG97CBdiuY_TKyeT8WHhb9NOHGd1gCqedP8q0d6qQYR-SSy4WctSFnUZ1ouVQKD_G5I7f8hW4sHKIZvVzLsHrw_3LZlvunh-fNutdqVBLUqk15ZaR1mrUacs7SZC1kBjWdYZgibtON0ozTHhNEaI8BzBsOg0JN5gjhpfgZs57DP59MjGJ3k8hVxMFQg3BLcVthqoZepODEW60PgWp8tbm4HLVxuYvijVqGGE1o_TfQs1z42jbZOF2FlTwMQZjxTG4gwyfoobiNAyRhyFgKyjMLJlZO6UpmKicGZUR8-tgtFNuNH94X0kxj6k</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Bazso, Anna</creator><creator>Sevcic, Krisztina</creator><creator>Orban, Ilonka</creator><creator>Suto, Gabor</creator><creator>Poor, Gyula</creator><creator>Kiss, Emese</creator><creator>Balogh, Zsolt</creator><general>Future Medicine Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>200912</creationdate><title>Association of juvenile idiopathic arhrtitis and functional constipation</title><author>Bazso, Anna ; 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The cause of megacolon was only cleared in one case in the form of Hirschprung ’s disease. The skeletal symptoms could be classified as seronegative spondylathropathy. Surgical treatment resulted in the remission of arthritis in one case and a possible pathogenic explanation is discussed. Common genetic predisposition is a plausible explanation, but fecal stasis leading to increased permeability to macromolecules, increased exposure to microbial and dietary antigens, loss of tolerance to own bacterial flora and host susceptibility to the increased antigenic load may stand in the background of this infrequent and not yet described association between juvenile idiopathic arthritis and functional constipation.</abstract><cop>London</cop><pub>Future Medicine Ltd</pub><doi>10.2217/ijr.09.60</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 1758-4272 |
| ispartof | International journal of clinical rheumatology, 2009-12, Vol.4 (6), p.673-680 |
| issn | 1758-4272 1758-4280 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Antiarthritic agents Arthritis bacterial colonization Constipation Diagnosis Drug therapy Health aspects Hirschprung ’s disease JIA juvenile idiopathic arthritis Permeability Risk factors |
| title | Association of juvenile idiopathic arhrtitis and functional constipation |
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