GPR 30 reduces myocardial infarct area and fibrosis in female ovariectomized mice by activating the PI3K/AKT pathway

Estrogen plays an important role in cardioprotection. Animal experiments showed that the G-protein coupled estrogen receptor 30 (GPR30) specific agonist G1 could reduce post-ischemic dysfunction and inhibit cardiac fibroblast proliferation. However, the underlying mechanism of action is not clear. T...

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Veröffentlicht in:	Life sciences (1973) 2019-06, Vol.226, p.22-32
Hauptverfasser:	Wang, Xiaowu, Lu, Linhe, Tan, Yanzhen, Jiang, Liqing, Zhao, Minggao, Gao, Erhe, Yu, Shiqiang, Liu, Jincheng
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animal models Animals Apoptosis Benzodioxoles - pharmacokinetics Cardiac fibroblasts Cardioprotection Cell Proliferation Computer simulation Deprivation Disease Models, Animal Echocardiography Estrogens Female Fibroblasts Fibroblasts - metabolism Fibrosis Fibrosis - metabolism G-protein coupled estrogen receptor 30 (GPR30) Heart - physiology Hemodynamics Hypoxia Hypoxia/serum deprivation (H/SD) Immunofluorescence In vivo methods and tests Interleukin 10 Ischemia Mice Mice, Inbred C57BL Morphology Myocardial infarction Myocardial infarction (MI) Myocardial Infarction - metabolism Myocardium - metabolism Ovariectomy Phosphatidylinositol 3-Kinases Proteins Proto-Oncogene Proteins c-akt Quinolines Receptors, Estrogen - metabolism Receptors, Estrogen - physiology Receptors, G-Protein-Coupled - agonists Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Signal Transduction Tumor necrosis factor-α Western blotting
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