A Cationic Iridium-catalyzed C(sp3)–H Silylation of 2-Alkyl-1,3-azoles at the α-Position in the 2-Alkyl Group Leading to 2-(1-Silylalkyl)-1,3-azoles
The regioselective silylation of the α-C(sp3)–H bond in the 2-alkyl group in 2-alkyl-1,3-azole derivatives with hydrosilanes, catalyzed by the combination of (POCOPtBu)IrHCl and NaBArF4, leading to the production of 2-(1-silylalkyl)-1,3-azoles is described. The presence of 3,5-dimethylpyridine is re...
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| Veröffentlicht in: | Chemistry letters 2018-01, Vol.47 (3), p.385 |
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| container_issue | 3 |
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| container_title | Chemistry letters |
| container_volume | 47 |
| creator | Hirano, Masaya Fukumoto, Yoshiya Matsubara, Nao Chatani, Naoto |
| description | The regioselective silylation of the α-C(sp3)–H bond in the 2-alkyl group in 2-alkyl-1,3-azole derivatives with hydrosilanes, catalyzed by the combination of (POCOPtBu)IrHCl and NaBArF4, leading to the production of 2-(1-silylalkyl)-1,3-azoles is described. The presence of 3,5-dimethylpyridine is required for the reaction to procced. Although the reaction takes place both in the presence and absence of a hydrogen acceptor, the addition of an acceptor gave better results, in terms of the efficiency of the reaction. |
| doi_str_mv | 10.1246/cl.171137 |
| format | Article |
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The presence of 3,5-dimethylpyridine is required for the reaction to procced. 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The presence of 3,5-dimethylpyridine is required for the reaction to procced. Although the reaction takes place both in the presence and absence of a hydrogen acceptor, the addition of an acceptor gave better results, in terms of the efficiency of the reaction.</abstract><cop>Tokyo</cop><pub>Chemical Society of Japan</pub><doi>10.1246/cl.171137</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0366-7022 |
| ispartof | Chemistry letters, 2018-01, Vol.47 (3), p.385 |
| issn | 0366-7022 1348-0715 |
| language | eng ; fre ; ger ; jpn |
| recordid | cdi_proquest_journals_2241366736 |
| source | Oxford University Press Journals All Titles (1996-Current) |
| subjects | Antifungal agents Heterocyclic compounds Hydrogen bonds Iridium |
| title | A Cationic Iridium-catalyzed C(sp3)–H Silylation of 2-Alkyl-1,3-azoles at the α-Position in the 2-Alkyl Group Leading to 2-(1-Silylalkyl)-1,3-azoles |
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