Computational Models for Activated Human MEK1: Identification of Key Active Site Residues and Interactions

MEK1 is a protein kinase in the MAPK cellular signaling pathway that is notable for its dual specificity and its potential as a drug target for a variety of cancer therapies. While much is known about the key role of MEK1 in signaling events, understanding of the structural features that sustain MEK...

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Veröffentlicht in:	Journal of chemical information and modeling 2019-05, Vol.59 (5), p.2383-2393
Hauptverfasser:	Sabsay, Kimberly R, Lee, Rebecca T, Ravatt, Leandre M, Oza, Javin P, McDonald, Ashley Ringer
Format:	Artikel
Sprache:	eng
Schlagworte:	Computation Computer simulation Crystal structure Docking Homology Kinases Molecular dynamics NMR Nuclear magnetic resonance Phosphorylation Proteins Residues Signaling
Online-Zugang:	Volltext
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