Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications
Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cro...
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| Veröffentlicht in: | Journal of nanomaterials 2019-01, Vol.2019 (2019), p.1-16 |
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| creator | Din, Fakhar-ud Ahmad, Naveed Zeb, Alam Shah, Kifayat Ullah Dar, Muhammad Junaid Afzal, Iqra Qindeel, Maimoona Asad, Muhammad Imran Sabir, Fakhara Khan, Gul Majid |
| description | Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone of research with speedy developments taking place on a daily basis. An incredible amount of focus is placed on the fabrication of NGs with novel polymers to achieve better control over the drug release. This review article covers a number of aspects of NGs including their types, associated pros and cons, and methods of preparation along with technical and economical superiority and therapeutic efficacy over each other. The last part of review summarizes the applications of NGs in the drug delivery and treatment of various diseases including brain disease, cardiovascular diseases, oxidative stress, diabetes, cancer therapy, tissue engineering, gene therapy, inflammatory disorders, pain management, ophthalmic and autoimmune diseases, and their future challenges. NGs appear to be an outstanding nominee for drug delivery systems, and further study is required to explore their interactions at the cellular and molecular levels. |
| doi_str_mv | 10.1155/2019/1526186 |
| format | Article |
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Among these nanomaterials, nanogels (NGs) are promising drug delivery systems and are composed of cross-linked polymeric nanoparticles ranging from 100 to 200 nm. NGs represent an innovative zone of research with speedy developments taking place on a daily basis. An incredible amount of focus is placed on the fabrication of NGs with novel polymers to achieve better control over the drug release. This review article covers a number of aspects of NGs including their types, associated pros and cons, and methods of preparation along with technical and economical superiority and therapeutic efficacy over each other. The last part of review summarizes the applications of NGs in the drug delivery and treatment of various diseases including brain disease, cardiovascular diseases, oxidative stress, diabetes, cancer therapy, tissue engineering, gene therapy, inflammatory disorders, pain management, ophthalmic and autoimmune diseases, and their future challenges. NGs appear to be an outstanding nominee for drug delivery systems, and further study is required to explore their interactions at the cellular and molecular levels.</description><identifier>ISSN: 1687-4110</identifier><identifier>EISSN: 1687-4129</identifier><identifier>DOI: 10.1155/2019/1526186</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Anesthesia ; Autoimmune diseases ; Biomedical materials ; Brain ; Cancer therapies ; Crosslinking ; Drug delivery systems ; Drugs ; Engineering ; Gene therapy ; Heart diseases ; Hydrogels ; Low molecular weights ; Microemulsions ; Nanomaterials ; Nanoparticles ; Nanotechnology ; Organic chemistry ; Pain ; Pharmaceuticals ; Phase transitions ; Physiology ; Polymers ; Quantum dots ; Retention ; Tissue engineering</subject><ispartof>Journal of nanomaterials, 2019-01, Vol.2019 (2019), p.1-16</ispartof><rights>Copyright © 2019 Fakhara Sabir et al.</rights><rights>Copyright © 2019 Fakhara Sabir et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-b9636a7e6c45bc007605b6eddf5c9f0865006b40fa141b1b6f9544d43ab54ba73</citedby><cites>FETCH-LOGICAL-c360t-b9636a7e6c45bc007605b6eddf5c9f0865006b40fa141b1b6f9544d43ab54ba73</cites><orcidid>0000-0002-4780-9945 ; 0000-0001-9537-4897 ; 0000-0003-3753-034X ; 0000-0003-4061-8174</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><contributor>Wang, Ruibing</contributor><creatorcontrib>Din, Fakhar-ud</creatorcontrib><creatorcontrib>Ahmad, Naveed</creatorcontrib><creatorcontrib>Zeb, Alam</creatorcontrib><creatorcontrib>Shah, Kifayat Ullah</creatorcontrib><creatorcontrib>Dar, Muhammad Junaid</creatorcontrib><creatorcontrib>Afzal, Iqra</creatorcontrib><creatorcontrib>Qindeel, Maimoona</creatorcontrib><creatorcontrib>Asad, Muhammad Imran</creatorcontrib><creatorcontrib>Sabir, Fakhara</creatorcontrib><creatorcontrib>Khan, Gul Majid</creatorcontrib><title>Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications</title><title>Journal of nanomaterials</title><description>Nanomaterials have found extensive biomedical applications in the past few years because of their small size, low molecular weight, larger surface area, enhanced biological, and chemical reactivity. 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| subjects | Anesthesia Autoimmune diseases Biomedical materials Brain Cancer therapies Crosslinking Drug delivery systems Drugs Engineering Gene therapy Heart diseases Hydrogels Low molecular weights Microemulsions Nanomaterials Nanoparticles Nanotechnology Organic chemistry Pain Pharmaceuticals Phase transitions Physiology Polymers Quantum dots Retention Tissue engineering |
| title | Polymeric Nanogels as Versatile Nanoplatforms for Biomedical Applications |
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