PTU-009 Long-term effects of obeticholic acid in patients with primary biliary cholangitis on inflammatory markers

IntroductionObeticholic Acid (OCA) is a potent and selective farnesoid X receptor agonist approved for the treatment of primary biliary cholangitis (PBC). PBC is a chronic liver disease characterized by the immune mediated destruction of bile ducts resulting in cholestasis, cirrhosis and liver failu...

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Veröffentlicht in:	Gut 2019-06, Vol.68 (Suppl 2), p.A115
Hauptverfasser:	Hirschfield, Gideon M, Nevens, Frederik, Shiffman, Mitchell L, Drenth, Joost PH, Bowlus, Christopher L, Vargas, Victor, Andreone, Pietro, Ryder, Stephen, Liberman, Alexander, Malecha, Elizabeth Smoot, MacConell, Leigh, Trauner, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bile ducts C-reactive protein Cholangitis Cholestasis Cirrhosis Clinical trials Cytokeratin Immunoglobulin A Immunoglobulin G Immunoglobulin M Inflammation Interleukin 12 Liver cirrhosis Liver diseases Long-term effects Patients Transforming growth factor Tumor necrosis factor-TNF Tumor necrosis factor-α
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