The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers
Previous studies have suggested that higher intakes of vitamin E (alpha-tocopherol) and beta carotene may be associated with a reduced risk of lung cancer. In particular, epidemiologic studies have linked the intake of vegetables rich in beta carotene with a lower risk of cancer (especially lung can...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 1994-04, Vol.330 (15), p.1029-1035 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1035 |
|---|---|
| container_issue | 15 |
| container_start_page | 1029 |
| container_title | The New England journal of medicine |
| container_volume | 330 |
| creator | Heinonen, Olli P Albanes, Demetrius Huttunen, J K Haapakoski, J |
| description | Previous studies have suggested that higher intakes of vitamin E (alpha-tocopherol) and beta carotene may be associated with a reduced risk of lung cancer. In particular, epidemiologic studies have linked the intake of vegetables rich in beta carotene with a lower risk of cancer (especially lung cancer) and have suggested that certain micronutrients are inhibitors of cancer
1
,
2
. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study was a randomized, double-blind, placebo-controlled primary-prevention trial undertaken to determine whether supplementation with alpha-tocopherol, beta carotene, or both would reduce the incidence of lung cancer in male smokers. A secondary outcome of interest was . . . |
| doi_str_mv | 10.1056/NEJM199404143301501 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_223988511</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>5599142</sourcerecordid><originalsourceid>FETCH-LOGICAL-c620t-18d0416e2075f46a710e08fddeec94e34dce039de61571da125fc366503763a33</originalsourceid><addsrcrecordid>eNp9kU1vFDEMhiMEapfSX4AqRcANDcT5nBzb1QJFW3qgcB2FxGlnu5Npk9kD_560O-oJ8MVy_LyvFZuQ18A-AFP647fV1wuwVjIJUggGisEzsgAlRCMl08_JgjHeNtJYcUhelrJhNUDaA3LQAjeC2wW5vbpBuooR_UTHSH_2kxv6RFfUpUDPcHJ06fI4YUI6JjpV-Dz5PmDy-MCvd-m6ErXKj4rLSuT5odBqdOG2SL8P422tX5EX0W0LHs_5iPz4tLpafmnWl5_Pl6frxmvOpgbaUH-kkTOjotTOAEPWxhAQvZUoZPDIhA2oQRkIDriKXmitmDBaOCGOyJu9710e73dYpm4z7nKqIzvOhW1bBVCht_-CwLbCGGUUr5TYUz6PpWSM3V3uB5d_d8C6hyN0fzlCVZ3M3rtfA4Ynzbz12n83913xbhtz3VdfnjAJYFplKvZ-jw1D6RJuhv8O_QOvUpb-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1983775752</pqid></control><display><type>article</type><title>The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>ProQuest Central UK/Ireland</source><source>New England Journal of Medicine</source><creator>Heinonen, Olli P ; Albanes, Demetrius ; Huttunen, J K ; Haapakoski, J</creator><creatorcontrib>Heinonen, Olli P ; Albanes, Demetrius ; Huttunen, J K ; Haapakoski, J ; The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group ; Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group</creatorcontrib><description>Previous studies have suggested that higher intakes of vitamin E (alpha-tocopherol) and beta carotene may be associated with a reduced risk of lung cancer. In particular, epidemiologic studies have linked the intake of vegetables rich in beta carotene with a lower risk of cancer (especially lung cancer) and have suggested that certain micronutrients are inhibitors of cancer
1
,
2
. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study was a randomized, double-blind, placebo-controlled primary-prevention trial undertaken to determine whether supplementation with alpha-tocopherol, beta carotene, or both would reduce the incidence of lung cancer in male smokers. A secondary outcome of interest was . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199404143301501</identifier><identifier>PMID: 8127329</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Aged ; beta Carotene ; Biological and medical sciences ; Carotenoids - adverse effects ; Carotenoids - therapeutic use ; Cause of Death ; Coronary artery disease ; Dietary supplements ; Disease prevention ; Double-Blind Method ; Double-blind studies ; Epidemiology ; Finland - epidemiology ; Heart diseases ; Hemorrhage ; Humans ; Incidence ; Ischemia ; Lung cancer ; Lung Neoplasms - etiology ; Lung Neoplasms - mortality ; Lung Neoplasms - prevention & control ; Male ; Medical research ; Medical sciences ; Mens health ; Middle Aged ; Mortality ; Pneumology ; Prostate cancer ; Public health ; Serum levels ; Smoking - adverse effects ; Stroke ; Tumors of the respiratory system and mediastinum ; Vegetables ; Vitamin A ; Vitamin E ; Vitamin E - adverse effects ; Vitamin E - therapeutic use ; Womens health</subject><ispartof>The New England journal of medicine, 1994-04, Vol.330 (15), p.1029-1035</ispartof><rights>Copyright © 1994 Massachusetts Medical Society. All rights reserved.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-18d0416e2075f46a710e08fddeec94e34dce039de61571da125fc366503763a33</citedby><cites>FETCH-LOGICAL-c620t-18d0416e2075f46a710e08fddeec94e34dce039de61571da125fc366503763a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199404143301501$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983775752?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4117857$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8127329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heinonen, Olli P</creatorcontrib><creatorcontrib>Albanes, Demetrius</creatorcontrib><creatorcontrib>Huttunen, J K</creatorcontrib><creatorcontrib>Haapakoski, J</creatorcontrib><creatorcontrib>The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group</creatorcontrib><creatorcontrib>Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group</creatorcontrib><title>The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Previous studies have suggested that higher intakes of vitamin E (alpha-tocopherol) and beta carotene may be associated with a reduced risk of lung cancer. In particular, epidemiologic studies have linked the intake of vegetables rich in beta carotene with a lower risk of cancer (especially lung cancer) and have suggested that certain micronutrients are inhibitors of cancer
1
,
2
. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study was a randomized, double-blind, placebo-controlled primary-prevention trial undertaken to determine whether supplementation with alpha-tocopherol, beta carotene, or both would reduce the incidence of lung cancer in male smokers. A secondary outcome of interest was . . .</description><subject>Aged</subject><subject>beta Carotene</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - adverse effects</subject><subject>Carotenoids - therapeutic use</subject><subject>Cause of Death</subject><subject>Coronary artery disease</subject><subject>Dietary supplements</subject><subject>Disease prevention</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Epidemiology</subject><subject>Finland - epidemiology</subject><subject>Heart diseases</subject><subject>Hemorrhage</subject><subject>Humans</subject><subject>Incidence</subject><subject>Ischemia</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - etiology</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - prevention & control</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Pneumology</subject><subject>Prostate cancer</subject><subject>Public health</subject><subject>Serum levels</subject><subject>Smoking - adverse effects</subject><subject>Stroke</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Vegetables</subject><subject>Vitamin A</subject><subject>Vitamin E</subject><subject>Vitamin E - adverse effects</subject><subject>Vitamin E - therapeutic use</subject><subject>Womens health</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kU1vFDEMhiMEapfSX4AqRcANDcT5nBzb1QJFW3qgcB2FxGlnu5Npk9kD_560O-oJ8MVy_LyvFZuQ18A-AFP647fV1wuwVjIJUggGisEzsgAlRCMl08_JgjHeNtJYcUhelrJhNUDaA3LQAjeC2wW5vbpBuooR_UTHSH_2kxv6RFfUpUDPcHJ06fI4YUI6JjpV-Dz5PmDy-MCvd-m6ErXKj4rLSuT5odBqdOG2SL8P422tX5EX0W0LHs_5iPz4tLpafmnWl5_Pl6frxmvOpgbaUH-kkTOjotTOAEPWxhAQvZUoZPDIhA2oQRkIDriKXmitmDBaOCGOyJu9710e73dYpm4z7nKqIzvOhW1bBVCht_-CwLbCGGUUr5TYUz6PpWSM3V3uB5d_d8C6hyN0fzlCVZ3M3rtfA4Ynzbz12n83913xbhtz3VdfnjAJYFplKvZ-jw1D6RJuhv8O_QOvUpb-</recordid><startdate>19940414</startdate><enddate>19940414</enddate><creator>Heinonen, Olli P</creator><creator>Albanes, Demetrius</creator><creator>Huttunen, J K</creator><creator>Haapakoski, J</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19940414</creationdate><title>The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers</title><author>Heinonen, Olli P ; Albanes, Demetrius ; Huttunen, J K ; Haapakoski, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-18d0416e2075f46a710e08fddeec94e34dce039de61571da125fc366503763a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Aged</topic><topic>beta Carotene</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - adverse effects</topic><topic>Carotenoids - therapeutic use</topic><topic>Cause of Death</topic><topic>Coronary artery disease</topic><topic>Dietary supplements</topic><topic>Disease prevention</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Epidemiology</topic><topic>Finland - epidemiology</topic><topic>Heart diseases</topic><topic>Hemorrhage</topic><topic>Humans</topic><topic>Incidence</topic><topic>Ischemia</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - etiology</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - prevention & control</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Pneumology</topic><topic>Prostate cancer</topic><topic>Public health</topic><topic>Serum levels</topic><topic>Smoking - adverse effects</topic><topic>Stroke</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Vegetables</topic><topic>Vitamin A</topic><topic>Vitamin E</topic><topic>Vitamin E - adverse effects</topic><topic>Vitamin E - therapeutic use</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heinonen, Olli P</creatorcontrib><creatorcontrib>Albanes, Demetrius</creatorcontrib><creatorcontrib>Huttunen, J K</creatorcontrib><creatorcontrib>Haapakoski, J</creatorcontrib><creatorcontrib>The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group</creatorcontrib><creatorcontrib>Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heinonen, Olli P</au><au>Albanes, Demetrius</au><au>Huttunen, J K</au><au>Haapakoski, J</au><aucorp>The Alpha-Tocopherol Beta Carotene Cancer Prevention Study Group</aucorp><aucorp>Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1994-04-14</date><risdate>1994</risdate><volume>330</volume><issue>15</issue><spage>1029</spage><epage>1035</epage><pages>1029-1035</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Previous studies have suggested that higher intakes of vitamin E (alpha-tocopherol) and beta carotene may be associated with a reduced risk of lung cancer. In particular, epidemiologic studies have linked the intake of vegetables rich in beta carotene with a lower risk of cancer (especially lung cancer) and have suggested that certain micronutrients are inhibitors of cancer
1
,
2
. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study was a randomized, double-blind, placebo-controlled primary-prevention trial undertaken to determine whether supplementation with alpha-tocopherol, beta carotene, or both would reduce the incidence of lung cancer in male smokers. A secondary outcome of interest was . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>8127329</pmid><doi>10.1056/NEJM199404143301501</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1994-04, Vol.330 (15), p.1029-1035 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_223988511 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Aged beta Carotene Biological and medical sciences Carotenoids - adverse effects Carotenoids - therapeutic use Cause of Death Coronary artery disease Dietary supplements Disease prevention Double-Blind Method Double-blind studies Epidemiology Finland - epidemiology Heart diseases Hemorrhage Humans Incidence Ischemia Lung cancer Lung Neoplasms - etiology Lung Neoplasms - mortality Lung Neoplasms - prevention & control Male Medical research Medical sciences Mens health Middle Aged Mortality Pneumology Prostate cancer Public health Serum levels Smoking - adverse effects Stroke Tumors of the respiratory system and mediastinum Vegetables Vitamin A Vitamin E Vitamin E - adverse effects Vitamin E - therapeutic use Womens health |
| title | The Effect of Vitamin E and Beta Carotene on the Incidence of Lung Cancer and Other Cancers in Male Smokers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T04%3A08%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Vitamin%20E%20and%20Beta%20Carotene%20on%20the%20Incidence%20of%20Lung%20Cancer%20and%20Other%20Cancers%20in%20Male%20Smokers&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Heinonen,%20Olli%20P&rft.aucorp=The%20Alpha-Tocopherol%20Beta%20Carotene%20Cancer%20Prevention%20Study%20Group&rft.date=1994-04-14&rft.volume=330&rft.issue=15&rft.spage=1029&rft.epage=1035&rft.pages=1029-1035&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJM199404143301501&rft_dat=%3Cproquest_cross%3E5599142%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1983775752&rft_id=info:pmid/8127329&rfr_iscdi=true |