A Controlled Study of Adenoviral-Vector–Mediated Gene Transfer in the Nasal Epithelium of Patients with Cystic Fibrosis

Cystic fibrosis is a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator ( CFTR ) gene. 1 – 4 The normal CFTR gene codes for a protein (CFTR) that plays a key part in epithelial transport of salt and water. 5 , 6 Mutations in CFTR result in abnorm...

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