Endogenous Hormones and the Risk of Hip and Vertebral Fractures among Older Women

In postmenopausal women, vertebral fractures are often attributed to low estrogen production, and hip fractures to secondary hyperparathyroidism due to age-related declines in calcium intake and in calcium absorption mediated by 1,25-dihydroxyvitamin D (1,25(OH) 2 vitamin D). 1 , 2 The results of re...

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Veröffentlicht in:The New England journal of medicine 1998-09, Vol.339 (11), p.733-738
Hauptverfasser: Cummings, Steven R, Browner, Warren S, Bauer, Douglas, Stone, Katie, Ensrud, Kristine, Jamal, Sophie, Ettinger, Bruce
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container_end_page 738
container_issue 11
container_start_page 733
container_title The New England journal of medicine
container_volume 339
creator Cummings, Steven R
Browner, Warren S
Bauer, Douglas
Stone, Katie
Ensrud, Kristine
Jamal, Sophie
Ettinger, Bruce
description In postmenopausal women, vertebral fractures are often attributed to low estrogen production, and hip fractures to secondary hyperparathyroidism due to age-related declines in calcium intake and in calcium absorption mediated by 1,25-dihydroxyvitamin D (1,25(OH) 2 vitamin D). 1 , 2 The results of retrospective case–control studies of the association between these hormones and the incidence of hip or vertebral fracture are conflicting, because of the alterations in serum hormone or vitamin D concentrations that result from fracture, the selection of nonrepresentative case and control subjects, and the use of insensitive assays for serum estradiol. 3 – 11 To determine the effects of endogenous hormones . . .
doi_str_mv 10.1056/NEJM199809103391104
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source EZB-FREE-00999 freely available EZB journals; New England Journal of Medicine Current
subjects Biological and medical sciences
Bone density
Fractures
Hormones. Endocrine system
Medical sciences
Older people
Pharmacology. Drug treatments
Vitamin D
Women
title Endogenous Hormones and the Risk of Hip and Vertebral Fractures among Older Women
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