Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension
Pulmonary hypertension is generally characterized by increased thickening of the walls of pulmonary arteries, narrowing of the pulmonary-artery lumen, increased pulmonary vascular resistance, and right-sided heart failure. 1 – 3 Clinically, patients have increasing dyspnea, cyanosis, precordial disc...
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| Veröffentlicht in: | The New England journal of medicine 1995-07, Vol.333 (4), p.214-221 |
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| creator | Giaid, Adel Saleh, Dina |
| description | Pulmonary hypertension is generally characterized by increased thickening of the walls of pulmonary arteries, narrowing of the pulmonary-artery lumen, increased pulmonary vascular resistance, and right-sided heart failure.
1
–
3
Clinically, patients have increasing dyspnea, cyanosis, precordial discomfort, anginal pain, and cardiomegaly.
1
–
3
Histologically, pulmonary arteries with such resistance, particularly those less than 100 μm in diameter, show various degrees of intimal thickening and muscular hypertrophy.
1
,
4
,
5
Pulmonary hypertension can be either idiopathic (primary) or due to other disease conditions. A number of humoral factors have been implicated in the pathogenesis of pulmonary hypertension, but there is no evidence that any . . . |
| doi_str_mv | 10.1056/NEJM199507273330403 |
| format | Article |
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1
–
3
Clinically, patients have increasing dyspnea, cyanosis, precordial discomfort, anginal pain, and cardiomegaly.
1
–
3
Histologically, pulmonary arteries with such resistance, particularly those less than 100 μm in diameter, show various degrees of intimal thickening and muscular hypertrophy.
1
,
4
,
5
Pulmonary hypertension can be either idiopathic (primary) or due to other disease conditions. A number of humoral factors have been implicated in the pathogenesis of pulmonary hypertension, but there is no evidence that any . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199507273330403</identifier><identifier>PMID: 7540722</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Amino Acid Oxidoreductases - analysis ; Biological and medical sciences ; Case-Control Studies ; Endothelium ; Endothelium, Vascular - enzymology ; Epithelium ; Epithelium - enzymology ; Female ; Humans ; Hypertension ; Hypertension, Pulmonary - enzymology ; Immunoreactivity ; Laboratories ; Lung - blood supply ; Lung - enzymology ; Lungs ; Male ; Medical sciences ; Middle Aged ; NADPH Dehydrogenase - analysis ; Nitric oxide ; Nitric Oxide Synthase ; Pneumology ; Pulmonary arteries ; Pulmonary artery ; Pulmonary Artery - enzymology ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Rodents ; Smooth muscle ; Vasoconstriction ; Veins & arteries</subject><ispartof>The New England journal of medicine, 1995-07, Vol.333 (4), p.214-221</ispartof><rights>Copyright © 1995 Massachusetts Medical Society. All rights reserved.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-6866188c4b016014d8ad734d35abe336483c765dc426ac732bfbe518307d31283</citedby><cites>FETCH-LOGICAL-c571t-6866188c4b016014d8ad734d35abe336483c765dc426ac732bfbe518307d31283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199507273330403$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983916967?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3604181$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7540722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giaid, Adel</creatorcontrib><creatorcontrib>Saleh, Dina</creatorcontrib><title>Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Pulmonary hypertension is generally characterized by increased thickening of the walls of pulmonary arteries, narrowing of the pulmonary-artery lumen, increased pulmonary vascular resistance, and right-sided heart failure.
1
–
3
Clinically, patients have increasing dyspnea, cyanosis, precordial discomfort, anginal pain, and cardiomegaly.
1
–
3
Histologically, pulmonary arteries with such resistance, particularly those less than 100 μm in diameter, show various degrees of intimal thickening and muscular hypertrophy.
1
,
4
,
5
Pulmonary hypertension can be either idiopathic (primary) or due to other disease conditions. A number of humoral factors have been implicated in the pathogenesis of pulmonary hypertension, but there is no evidence that any . . .</description><subject>Adult</subject><subject>Amino Acid Oxidoreductases - analysis</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - enzymology</subject><subject>Epithelium</subject><subject>Epithelium - enzymology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Pulmonary - enzymology</subject><subject>Immunoreactivity</subject><subject>Laboratories</subject><subject>Lung - blood supply</subject><subject>Lung - enzymology</subject><subject>Lungs</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NADPH Dehydrogenase - analysis</subject><subject>Nitric oxide</subject><subject>Nitric Oxide Synthase</subject><subject>Pneumology</subject><subject>Pulmonary arteries</subject><subject>Pulmonary artery</subject><subject>Pulmonary Artery - enzymology</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Vasoconstriction</subject><subject>Veins & arteries</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kctu1DAUhi0EKkPhCRCSBeyqgO3j2M4SVUNLNb2IyzpybIfxKHEG2xGdt69HM-qqcDZncb7_PzeE3lLyiZJafL5ZXl3TpqmJZBIACCfwDC1oDVBxTsRztCCEqYrLBl6iVyltSAnKmxN0ImteVGyBhu_OzsZZvLzfRpeSnwKeerwMdsprN3g94Bufozf49t5bh3_sQl7r5LAPuAB4NYffaa-409m7kBP-6_Ma383DOAUdd_hyt3Uxu7B3fo1e9HpI7s0xn6JfX5c_zy-r1e3Ft_Mvq8rUkuZKKCGoUoZ3hIoysFXaSuAWat05AMEVGClqazgT2khgXd-5miog0gJlCk7R-4PvNk5_Zpdyu5nmGErLljFohGCCFOjDvyDaKGioaIQsFBwoE6eUouvbbfRjWaylpN1_oX3iC0X17ug9d6Ozj5rj2Uv947Guk9FDH3UwPj1iIAinihbs7ICNY2qD24z_bfoAZnuZxg</recordid><startdate>19950727</startdate><enddate>19950727</enddate><creator>Giaid, Adel</creator><creator>Saleh, Dina</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19950727</creationdate><title>Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension</title><author>Giaid, Adel ; Saleh, Dina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-6866188c4b016014d8ad734d35abe336483c765dc426ac732bfbe518307d31283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Amino Acid Oxidoreductases - analysis</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - enzymology</topic><topic>Epithelium</topic><topic>Epithelium - enzymology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Pulmonary - enzymology</topic><topic>Immunoreactivity</topic><topic>Laboratories</topic><topic>Lung - blood supply</topic><topic>Lung - enzymology</topic><topic>Lungs</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NADPH Dehydrogenase - analysis</topic><topic>Nitric oxide</topic><topic>Nitric Oxide Synthase</topic><topic>Pneumology</topic><topic>Pulmonary arteries</topic><topic>Pulmonary artery</topic><topic>Pulmonary Artery - enzymology</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Rodents</topic><topic>Smooth muscle</topic><topic>Vasoconstriction</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giaid, Adel</creatorcontrib><creatorcontrib>Saleh, Dina</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giaid, Adel</au><au>Saleh, Dina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1995-07-27</date><risdate>1995</risdate><volume>333</volume><issue>4</issue><spage>214</spage><epage>221</epage><pages>214-221</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Pulmonary hypertension is generally characterized by increased thickening of the walls of pulmonary arteries, narrowing of the pulmonary-artery lumen, increased pulmonary vascular resistance, and right-sided heart failure.
1
–
3
Clinically, patients have increasing dyspnea, cyanosis, precordial discomfort, anginal pain, and cardiomegaly.
1
–
3
Histologically, pulmonary arteries with such resistance, particularly those less than 100 μm in diameter, show various degrees of intimal thickening and muscular hypertrophy.
1
,
4
,
5
Pulmonary hypertension can be either idiopathic (primary) or due to other disease conditions. A number of humoral factors have been implicated in the pathogenesis of pulmonary hypertension, but there is no evidence that any . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>7540722</pmid><doi>10.1056/NEJM199507273330403</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1995-07, Vol.333 (4), p.214-221 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Amino Acid Oxidoreductases - analysis Biological and medical sciences Case-Control Studies Endothelium Endothelium, Vascular - enzymology Epithelium Epithelium - enzymology Female Humans Hypertension Hypertension, Pulmonary - enzymology Immunoreactivity Laboratories Lung - blood supply Lung - enzymology Lungs Male Medical sciences Middle Aged NADPH Dehydrogenase - analysis Nitric oxide Nitric Oxide Synthase Pneumology Pulmonary arteries Pulmonary artery Pulmonary Artery - enzymology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rodents Smooth muscle Vasoconstriction Veins & arteries |
| title | Reduced Expression of Endothelial Nitric Oxide Synthase in the Lungs of Patients with Pulmonary Hypertension |
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