Hyperfractionated Irradiation with or without Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer
Cure of locally advanced squamous-cell carcinoma of the head and neck is uncommon whether a single treatment, including high-dose external-beam irradiation, or a combination of treatments is used. The rate of relapse-free survival is approximately 25 percent, and most patients die from complications...
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| Veröffentlicht in: | The New England journal of medicine 1998-06, Vol.338 (25), p.1798-1804 |
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| container_title | The New England journal of medicine |
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| creator | Brizel, David M Albers, Mary E Fisher, Samuel R Scher, Richard L Richtsmeier, William J Hars, Vera George, Stephen L Huang, Andrew T Prosnitz, Leonard R |
| description | Cure of locally advanced squamous-cell carcinoma of the head and neck is uncommon whether a single treatment, including high-dose external-beam irradiation, or a combination of treatments is used. The rate of relapse-free survival is approximately 25 percent, and most patients die from complications of progressive local disease. Repopulation of tumor cells during treatment, tumor hypoxia, and resistance to radiotherapy have all been implicated as causes of treatment failure after primary radiotherapy.
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Accelerated fractionation irradiation, which shortens the total time of treatment, has been employed to increase the probability of locoregional control by reducing the risk of tumor repopulation. With . . . |
| doi_str_mv | 10.1056/NEJM199806183382503 |
| format | Article |
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Accelerated fractionation irradiation, which shortens the total time of treatment, has been employed to increase the probability of locoregional control by reducing the risk of tumor repopulation. With . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199806183382503</identifier><identifier>PMID: 9632446</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Aged ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Cancer therapies ; Chemotherapy ; Cisplatin - administration & dosage ; Combined Modality Therapy ; Disease-Free Survival ; Diseases of the upper aerodigestive tract ; Dose Fractionation ; Ent and stomatology ; Female ; Fluorouracil - administration & dosage ; Follow-Up Studies ; Head and Neck Neoplasms - drug therapy ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - radiotherapy ; Humans ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; Neoplasms, Squamous Cell - drug therapy ; Neoplasms, Squamous Cell - pathology ; Neoplasms, Squamous Cell - radiotherapy ; NMR ; Nuclear magnetic resonance ; Patients ; Radiation therapy ; Radiotherapy - adverse effects ; Radiotherapy - methods ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Studies ; Survival Analysis ; Treatment Outcome</subject><ispartof>The New England journal of medicine, 1998-06, Vol.338 (25), p.1798-1804</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-91df601e3bdafbf7ce6ac54e3177289f3e0ab1bee550ed6b529024c5502a1cd33</citedby><cites>FETCH-LOGICAL-c528t-91df601e3bdafbf7ce6ac54e3177289f3e0ab1bee550ed6b529024c5502a1cd33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199806183382503$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199806183382503$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2271190$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9632446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brizel, David M</creatorcontrib><creatorcontrib>Albers, Mary E</creatorcontrib><creatorcontrib>Fisher, Samuel R</creatorcontrib><creatorcontrib>Scher, Richard L</creatorcontrib><creatorcontrib>Richtsmeier, William J</creatorcontrib><creatorcontrib>Hars, Vera</creatorcontrib><creatorcontrib>George, Stephen L</creatorcontrib><creatorcontrib>Huang, Andrew T</creatorcontrib><creatorcontrib>Prosnitz, Leonard R</creatorcontrib><title>Hyperfractionated Irradiation with or without Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Cure of locally advanced squamous-cell carcinoma of the head and neck is uncommon whether a single treatment, including high-dose external-beam irradiation, or a combination of treatments is used. The rate of relapse-free survival is approximately 25 percent, and most patients die from complications of progressive local disease. Repopulation of tumor cells during treatment, tumor hypoxia, and resistance to radiotherapy have all been implicated as causes of treatment failure after primary radiotherapy.
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Accelerated fractionation irradiation, which shortens the total time of treatment, has been employed to increase the probability of locoregional control by reducing the risk of tumor repopulation. With . . .</description><subject>Aged</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Cisplatin - administration & dosage</subject><subject>Combined Modality Therapy</subject><subject>Disease-Free Survival</subject><subject>Diseases of the upper aerodigestive tract</subject><subject>Dose Fractionation</subject><subject>Ent and stomatology</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Head and Neck Neoplasms - drug therapy</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasms, Squamous Cell - drug therapy</subject><subject>Neoplasms, Squamous Cell - pathology</subject><subject>Neoplasms, Squamous Cell - radiotherapy</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Radiation therapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Radiotherapy - methods</subject><subject>Radiotherapy. 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The rate of relapse-free survival is approximately 25 percent, and most patients die from complications of progressive local disease. Repopulation of tumor cells during treatment, tumor hypoxia, and resistance to radiotherapy have all been implicated as causes of treatment failure after primary radiotherapy.
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Accelerated fractionation irradiation, which shortens the total time of treatment, has been employed to increase the probability of locoregional control by reducing the risk of tumor repopulation. With . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9632446</pmid><doi>10.1056/NEJM199806183382503</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1998-06, Vol.338 (25), p.1798-1804 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Cancer therapies Chemotherapy Cisplatin - administration & dosage Combined Modality Therapy Disease-Free Survival Diseases of the upper aerodigestive tract Dose Fractionation Ent and stomatology Female Fluorouracil - administration & dosage Follow-Up Studies Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - pathology Head and Neck Neoplasms - radiotherapy Humans Male Medical imaging Medical sciences Middle Aged Neoplasms, Squamous Cell - drug therapy Neoplasms, Squamous Cell - pathology Neoplasms, Squamous Cell - radiotherapy NMR Nuclear magnetic resonance Patients Radiation therapy Radiotherapy - adverse effects Radiotherapy - methods Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Studies Survival Analysis Treatment Outcome |
| title | Hyperfractionated Irradiation with or without Concurrent Chemotherapy for Locally Advanced Head and Neck Cancer |
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