Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)
ACUTE promyelocytic leukemia makes up approximately 15 percent of the adult acute nonlymphoblastic leukemias. 1 The disease is associated with a specific cytogenetic abnormality, the translocation of a portion of the long arm of chromosome 17 onto the long arm of chromosome 15 — t(15;17)(q22;ql2–21)...
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| Veröffentlicht in: | The New England journal of medicine 1991-05, Vol.324 (20), p.1385-1393 |
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| container_title | The New England journal of medicine |
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| creator | Warrell, Raymond P Frankel, Stanley R Miller, Wilson H Scheinberg, David A Itri, Loretta M Hittelman, Walter N Vyas, Rohini Andreeff, Michael Tafuri, Agostino Jakubowski, Ann Gabrilove, Janice Gordon, Michael S Dmitrovsky, Ethan |
| description | ACUTE promyelocytic leukemia makes up approximately 15 percent of the adult acute nonlymphoblastic leukemias.
1
The disease is associated with a specific cytogenetic abnormality, the translocation of a portion of the long arm of chromosome 17 onto the long arm of chromosome 15 — t(15;17)(q22;ql2–21).
2
During the past year, the breakpoint region for the chromosome 17 translocation has been cloned,
3
and molecular studies have revealed DNA rearrangements that clustered in the region of the first intron for the nuclear retinoic acid receptor—alpha (RAR-α).
4
'
5
This rearrangement resulted in the expression of abnormal messenger RNA (mRNA) transcripts for RAR-α.
6
7
8
These findings were of . . . |
| doi_str_mv | 10.1056/NEJM199105163242002 |
| format | Article |
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1
The disease is associated with a specific cytogenetic abnormality, the translocation of a portion of the long arm of chromosome 17 onto the long arm of chromosome 15 — t(15;17)(q22;ql2–21).
2
During the past year, the breakpoint region for the chromosome 17 translocation has been cloned,
3
and molecular studies have revealed DNA rearrangements that clustered in the region of the first intron for the nuclear retinoic acid receptor—alpha (RAR-α).
4
'
5
This rearrangement resulted in the expression of abnormal messenger RNA (mRNA) transcripts for RAR-α.
6
7
8
These findings were of . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199105163242002</identifier><identifier>PMID: 1850498</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Acute promyeloid leukemia ; Administration, Oral ; Adolescent ; Adult ; Aged ; Antigens ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Bone marrow ; Cancer therapies ; Carrier Proteins - drug effects ; Cell surface ; Chemotherapy ; Child ; Chromosome 17 ; Chromosome Aberrations ; Chromosomes ; Deoxyribonucleic acid ; DNA ; Drug dosages ; Female ; Flow Cytometry ; Fluorescence in situ hybridization ; Humans ; Immunoblotting ; Laboratories ; Leukemia ; Leukemia, Promyelocytic, Acute - drug therapy ; Leukemia, Promyelocytic, Acute - genetics ; Leukocyte Count ; Leukocytosis ; Male ; Medical sciences ; Middle Aged ; Myeloid cells ; Neoplasm Proteins - drug effects ; Patients ; Pharmacology. Drug treatments ; Promyeloid leukemia ; Receptors, Retinoic Acid ; Remission ; Remission Induction ; Retinoic acid ; Retinoic acid receptors ; Studies ; Transplants & implants ; Tretinoin - adverse effects ; Tretinoin - pharmacology ; Tretinoin - therapeutic use</subject><ispartof>The New England journal of medicine, 1991-05, Vol.324 (20), p.1385-1393</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society May 16, 1991</rights><rights>Copyright Massachusetts Medical Society, Publishing Division May 16, 1991</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-c2e3da9159358137ebf928c6003a3f91bffb9545daa5d3fb8ac2e06ea5de3bdd3</citedby><cites>FETCH-LOGICAL-c504t-c2e3da9159358137ebf928c6003a3f91bffb9545daa5d3fb8ac2e06ea5de3bdd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199105163242002$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223952968?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5314044$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1850498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warrell, Raymond P</creatorcontrib><creatorcontrib>Frankel, Stanley R</creatorcontrib><creatorcontrib>Miller, Wilson H</creatorcontrib><creatorcontrib>Scheinberg, David A</creatorcontrib><creatorcontrib>Itri, Loretta M</creatorcontrib><creatorcontrib>Hittelman, Walter N</creatorcontrib><creatorcontrib>Vyas, Rohini</creatorcontrib><creatorcontrib>Andreeff, Michael</creatorcontrib><creatorcontrib>Tafuri, Agostino</creatorcontrib><creatorcontrib>Jakubowski, Ann</creatorcontrib><creatorcontrib>Gabrilove, Janice</creatorcontrib><creatorcontrib>Gordon, Michael S</creatorcontrib><creatorcontrib>Dmitrovsky, Ethan</creatorcontrib><title>Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>ACUTE promyelocytic leukemia makes up approximately 15 percent of the adult acute nonlymphoblastic leukemias.
1
The disease is associated with a specific cytogenetic abnormality, the translocation of a portion of the long arm of chromosome 17 onto the long arm of chromosome 15 — t(15;17)(q22;ql2–21).
2
During the past year, the breakpoint region for the chromosome 17 translocation has been cloned,
3
and molecular studies have revealed DNA rearrangements that clustered in the region of the first intron for the nuclear retinoic acid receptor—alpha (RAR-α).
4
'
5
This rearrangement resulted in the expression of abnormal messenger RNA (mRNA) transcripts for RAR-α.
6
7
8
These findings were of . . .</description><subject>Acute promyeloid leukemia</subject><subject>Administration, Oral</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Blood. Blood coagulation. Reticuloendothelial system</subject><subject>Bone marrow</subject><subject>Cancer therapies</subject><subject>Carrier Proteins - drug effects</subject><subject>Cell surface</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Chromosome 17</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug dosages</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fluorescence in situ hybridization</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Laboratories</subject><subject>Leukemia</subject><subject>Leukemia, Promyelocytic, Acute - drug therapy</subject><subject>Leukemia, Promyelocytic, Acute - genetics</subject><subject>Leukocyte Count</subject><subject>Leukocytosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myeloid cells</subject><subject>Neoplasm Proteins - drug effects</subject><subject>Patients</subject><subject>Pharmacology. Drug treatments</subject><subject>Promyeloid leukemia</subject><subject>Receptors, Retinoic Acid</subject><subject>Remission</subject><subject>Remission Induction</subject><subject>Retinoic acid</subject><subject>Retinoic acid receptors</subject><subject>Studies</subject><subject>Transplants & implants</subject><subject>Tretinoin - adverse effects</subject><subject>Tretinoin - pharmacology</subject><subject>Tretinoin - therapeutic use</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kNtu1DAQhq0KVLYtT4CQIugFCIXaHjtrX67actICVbVcB8cZq15yWGxH1b59jbKCG2BuPIfvn7F-Qp4x-pZRWV18uf70mWmdc1YBF5xSfkQWTAKUQtDqEVnkjirFUsMTchLjluZgQh-TY6YkFVotyPcr7xwGHJI3yY9DsbnDYHb7YnTFyk4Ji5sw9nvsRrtP3hZrnH5g701x79NdsQmY_DD6oXi16royBTPE8nbu2az37esz8tiZLuLTw3tKvr273lx-KNdf33-8XK1Lm3-SSssRWqOZ1CAVgyU2TnNlK0rBgNOsca7RUsjWGNmCa5TJClphrhCatoVT8mLeuwvjzwljqrfjFIZ8suYctOS6Uhl6-S-IaQWCg1ryTMFM2TDGGNDVu-B7E_Y1o_Uv5-u_OJ9Vzw-7p6bH9o9mtjrPzw9zE63pXPbK-vgbk8AEFSJjb2as72M94Lb_79EHhsSW3w</recordid><startdate>19910516</startdate><enddate>19910516</enddate><creator>Warrell, Raymond P</creator><creator>Frankel, Stanley R</creator><creator>Miller, Wilson H</creator><creator>Scheinberg, David A</creator><creator>Itri, Loretta M</creator><creator>Hittelman, Walter N</creator><creator>Vyas, Rohini</creator><creator>Andreeff, Michael</creator><creator>Tafuri, Agostino</creator><creator>Jakubowski, Ann</creator><creator>Gabrilove, Janice</creator><creator>Gordon, Michael S</creator><creator>Dmitrovsky, Ethan</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19910516</creationdate><title>Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)</title><author>Warrell, Raymond P ; Frankel, Stanley R ; Miller, Wilson H ; Scheinberg, David A ; Itri, Loretta M ; Hittelman, Walter N ; Vyas, Rohini ; Andreeff, Michael ; Tafuri, Agostino ; Jakubowski, Ann ; Gabrilove, Janice ; Gordon, Michael S ; Dmitrovsky, Ethan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-c2e3da9159358137ebf928c6003a3f91bffb9545daa5d3fb8ac2e06ea5de3bdd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Acute promyeloid leukemia</topic><topic>Administration, Oral</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Blood. Blood coagulation. Reticuloendothelial system</topic><topic>Bone marrow</topic><topic>Cancer therapies</topic><topic>Carrier Proteins - drug effects</topic><topic>Cell surface</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Chromosome 17</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug dosages</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fluorescence in situ hybridization</topic><topic>Humans</topic><topic>Immunoblotting</topic><topic>Laboratories</topic><topic>Leukemia</topic><topic>Leukemia, Promyelocytic, Acute - drug therapy</topic><topic>Leukemia, Promyelocytic, Acute - genetics</topic><topic>Leukocyte Count</topic><topic>Leukocytosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myeloid cells</topic><topic>Neoplasm Proteins - drug effects</topic><topic>Patients</topic><topic>Pharmacology. Drug treatments</topic><topic>Promyeloid leukemia</topic><topic>Receptors, Retinoic Acid</topic><topic>Remission</topic><topic>Remission Induction</topic><topic>Retinoic acid</topic><topic>Retinoic acid receptors</topic><topic>Studies</topic><topic>Transplants & implants</topic><topic>Tretinoin - adverse effects</topic><topic>Tretinoin - pharmacology</topic><topic>Tretinoin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warrell, Raymond P</creatorcontrib><creatorcontrib>Frankel, Stanley R</creatorcontrib><creatorcontrib>Miller, Wilson H</creatorcontrib><creatorcontrib>Scheinberg, David A</creatorcontrib><creatorcontrib>Itri, Loretta M</creatorcontrib><creatorcontrib>Hittelman, Walter N</creatorcontrib><creatorcontrib>Vyas, Rohini</creatorcontrib><creatorcontrib>Andreeff, Michael</creatorcontrib><creatorcontrib>Tafuri, Agostino</creatorcontrib><creatorcontrib>Jakubowski, Ann</creatorcontrib><creatorcontrib>Gabrilove, Janice</creatorcontrib><creatorcontrib>Gordon, Michael S</creatorcontrib><creatorcontrib>Dmitrovsky, Ethan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warrell, Raymond P</au><au>Frankel, Stanley R</au><au>Miller, Wilson H</au><au>Scheinberg, David A</au><au>Itri, Loretta M</au><au>Hittelman, Walter N</au><au>Vyas, Rohini</au><au>Andreeff, Michael</au><au>Tafuri, Agostino</au><au>Jakubowski, Ann</au><au>Gabrilove, Janice</au><au>Gordon, Michael S</au><au>Dmitrovsky, Ethan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1991-05-16</date><risdate>1991</risdate><volume>324</volume><issue>20</issue><spage>1385</spage><epage>1393</epage><pages>1385-1393</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>ACUTE promyelocytic leukemia makes up approximately 15 percent of the adult acute nonlymphoblastic leukemias.
1
The disease is associated with a specific cytogenetic abnormality, the translocation of a portion of the long arm of chromosome 17 onto the long arm of chromosome 15 — t(15;17)(q22;ql2–21).
2
During the past year, the breakpoint region for the chromosome 17 translocation has been cloned,
3
and molecular studies have revealed DNA rearrangements that clustered in the region of the first intron for the nuclear retinoic acid receptor—alpha (RAR-α).
4
'
5
This rearrangement resulted in the expression of abnormal messenger RNA (mRNA) transcripts for RAR-α.
6
7
8
These findings were of . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>1850498</pmid><doi>10.1056/NEJM199105163242002</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1991-05, Vol.324 (20), p.1385-1393 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_223952968 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Acute promyeloid leukemia Administration, Oral Adolescent Adult Aged Antigens Biological and medical sciences Blood. Blood coagulation. Reticuloendothelial system Bone marrow Cancer therapies Carrier Proteins - drug effects Cell surface Chemotherapy Child Chromosome 17 Chromosome Aberrations Chromosomes Deoxyribonucleic acid DNA Drug dosages Female Flow Cytometry Fluorescence in situ hybridization Humans Immunoblotting Laboratories Leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukocyte Count Leukocytosis Male Medical sciences Middle Aged Myeloid cells Neoplasm Proteins - drug effects Patients Pharmacology. Drug treatments Promyeloid leukemia Receptors, Retinoic Acid Remission Remission Induction Retinoic acid Retinoic acid receptors Studies Transplants & implants Tretinoin - adverse effects Tretinoin - pharmacology Tretinoin - therapeutic use |
| title | Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid) |
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