Epidural Corticosteroid Injections for Sciatica Due to Herniated Nucleus Pulposus
Sciatica due to a herniated nucleus pulposus is an important medical and socioeconomic problem. 1 Although the majority of patients recover with conservative management, 10 to 15 percent need surgery. 2 Epidural corticosteroid injections were first used to treat sciatica in the early 1950s, as repor...
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| Veröffentlicht in: | The New England journal of medicine 1997-06, Vol.336 (23), p.1634-1640 |
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| container_title | The New England journal of medicine |
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| creator | Carette, Simon Leclaire, Richard Marcoux, Sylvie Morin, Frédéric Blaise, Gilbert A St.-Pierre, André Truchon, René Parent, François Lévesque, Jacques Bergeron, Vincent Montminy, Patrice Blanchette, Caty |
| description | Sciatica due to a herniated nucleus pulposus is an important medical and socioeconomic problem.
1
Although the majority of patients recover with conservative management, 10 to 15 percent need surgery.
2
Epidural corticosteroid injections were first used to treat sciatica in the early 1950s, as reported by Lièvre et al.
3
,
4
Of 12 controlled trials that have subsequently been reported, half found that the injections were more effective than the reference treatment,
5
–
10
and the other half found them to be no better or worse.
11
–
16
A critical analysis of these studies showed that most had methodologic deficiencies.
17
Reviews of the literature . . . |
| doi_str_mv | 10.1056/NEJM199706053362303 |
| format | Article |
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1
Although the majority of patients recover with conservative management, 10 to 15 percent need surgery.
2
Epidural corticosteroid injections were first used to treat sciatica in the early 1950s, as reported by Lièvre et al.
3
,
4
Of 12 controlled trials that have subsequently been reported, half found that the injections were more effective than the reference treatment,
5
–
10
and the other half found them to be no better or worse.
11
–
16
A critical analysis of these studies showed that most had methodologic deficiencies.
17
Reviews of the literature . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199706053362303</identifier><identifier>PMID: 9171065</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Diseases of the osteoarticular system ; Diseases of the spine ; Double-Blind Method ; Female ; Humans ; Injections, Epidural - adverse effects ; Intervertebral Disc Displacement - complications ; Intervertebral Disc Displacement - surgery ; Male ; Medical disorders ; Medical procedures ; Medical research ; Medical sciences ; Methylprednisolone - analogs & derivatives ; Methylprednisolone - therapeutic use ; Sciatica - drug therapy ; Sciatica - etiology ; Sciatica - physiopathology ; Steroids ; Treatment Outcome</subject><ispartof>The New England journal of medicine, 1997-06, Vol.336 (23), p.1634-1640</ispartof><rights>Copyright © 1997 Massachusetts Medical Society. All rights reserved.</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c594t-e50fd0dbeaf8aff1b3ffe89dfca2ab09e25e402cc051a098ccef2e683ad4c77e3</citedby><cites>FETCH-LOGICAL-c594t-e50fd0dbeaf8aff1b3ffe89dfca2ab09e25e402cc051a098ccef2e683ad4c77e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199706053362303$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM199706053362303$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2689326$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9171065$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carette, Simon</creatorcontrib><creatorcontrib>Leclaire, Richard</creatorcontrib><creatorcontrib>Marcoux, Sylvie</creatorcontrib><creatorcontrib>Morin, Frédéric</creatorcontrib><creatorcontrib>Blaise, Gilbert A</creatorcontrib><creatorcontrib>St.-Pierre, André</creatorcontrib><creatorcontrib>Truchon, René</creatorcontrib><creatorcontrib>Parent, François</creatorcontrib><creatorcontrib>Lévesque, Jacques</creatorcontrib><creatorcontrib>Bergeron, Vincent</creatorcontrib><creatorcontrib>Montminy, Patrice</creatorcontrib><creatorcontrib>Blanchette, Caty</creatorcontrib><title>Epidural Corticosteroid Injections for Sciatica Due to Herniated Nucleus Pulposus</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Sciatica due to a herniated nucleus pulposus is an important medical and socioeconomic problem.
1
Although the majority of patients recover with conservative management, 10 to 15 percent need surgery.
2
Epidural corticosteroid injections were first used to treat sciatica in the early 1950s, as reported by Lièvre et al.
3
,
4
Of 12 controlled trials that have subsequently been reported, half found that the injections were more effective than the reference treatment,
5
–
10
and the other half found them to be no better or worse.
11
–
16
A critical analysis of these studies showed that most had methodologic deficiencies.
17
Reviews of the literature . . .</description><subject>Adult</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Diseases of the spine</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Epidural - adverse effects</subject><subject>Intervertebral Disc Displacement - complications</subject><subject>Intervertebral Disc Displacement - surgery</subject><subject>Male</subject><subject>Medical disorders</subject><subject>Medical procedures</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Methylprednisolone - analogs & derivatives</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Sciatica - drug therapy</subject><subject>Sciatica - etiology</subject><subject>Sciatica - physiopathology</subject><subject>Steroids</subject><subject>Treatment Outcome</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kE1LxDAQhoMoun78AhGCeJPqJGna5ijr6ip-op5LNp1Al7ZZk-bgvzeyiydxLjPM-8w78BJyzOCCgSwun2b3j0ypEgqQQhRcgNgiE5bmLM-h2CYTAF5leanEHtkPYQmpWK52ya5iJYNCTsjrbNU20euOTp0fW-PCiN61Db0blmjG1g2BWufpm2l1kjW9jkhHR-foh7TBhj5F02EM9CV2KxdiOCQ7VncBjzb9gHzczN6n8-zh-fZuevWQGanyMUMJtoFmgdpW2lq2ENZipRprNNcLUMgl5sCNAck0qMoYtByLSugmN2WJ4oCcrn1X3n1GDGO9dNEP6WXNuVCSM1klSKwh410IHm298m2v_VfNoP4Jsf4jxHR1srGOix6b35tNakk_2-g6GN1ZrwfThl-MF5USvEjY-Rrr-1APuOz_ffoNhB6HHA</recordid><startdate>19970605</startdate><enddate>19970605</enddate><creator>Carette, Simon</creator><creator>Leclaire, Richard</creator><creator>Marcoux, Sylvie</creator><creator>Morin, Frédéric</creator><creator>Blaise, Gilbert A</creator><creator>St.-Pierre, André</creator><creator>Truchon, René</creator><creator>Parent, François</creator><creator>Lévesque, Jacques</creator><creator>Bergeron, Vincent</creator><creator>Montminy, Patrice</creator><creator>Blanchette, Caty</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>19970605</creationdate><title>Epidural Corticosteroid Injections for Sciatica Due to Herniated Nucleus Pulposus</title><author>Carette, Simon ; Leclaire, Richard ; Marcoux, Sylvie ; Morin, Frédéric ; Blaise, Gilbert A ; St.-Pierre, André ; Truchon, René ; Parent, François ; Lévesque, Jacques ; Bergeron, Vincent ; Montminy, Patrice ; Blanchette, Caty</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c594t-e50fd0dbeaf8aff1b3ffe89dfca2ab09e25e402cc051a098ccef2e683ad4c77e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Diseases of the spine</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Epidural - adverse effects</topic><topic>Intervertebral Disc Displacement - complications</topic><topic>Intervertebral Disc Displacement - surgery</topic><topic>Male</topic><topic>Medical disorders</topic><topic>Medical procedures</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Methylprednisolone - analogs & derivatives</topic><topic>Methylprednisolone - therapeutic use</topic><topic>Sciatica - drug therapy</topic><topic>Sciatica - etiology</topic><topic>Sciatica - physiopathology</topic><topic>Steroids</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carette, Simon</creatorcontrib><creatorcontrib>Leclaire, Richard</creatorcontrib><creatorcontrib>Marcoux, Sylvie</creatorcontrib><creatorcontrib>Morin, Frédéric</creatorcontrib><creatorcontrib>Blaise, Gilbert A</creatorcontrib><creatorcontrib>St.-Pierre, André</creatorcontrib><creatorcontrib>Truchon, René</creatorcontrib><creatorcontrib>Parent, François</creatorcontrib><creatorcontrib>Lévesque, Jacques</creatorcontrib><creatorcontrib>Bergeron, Vincent</creatorcontrib><creatorcontrib>Montminy, Patrice</creatorcontrib><creatorcontrib>Blanchette, Caty</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carette, Simon</au><au>Leclaire, Richard</au><au>Marcoux, Sylvie</au><au>Morin, Frédéric</au><au>Blaise, Gilbert A</au><au>St.-Pierre, André</au><au>Truchon, René</au><au>Parent, François</au><au>Lévesque, Jacques</au><au>Bergeron, Vincent</au><au>Montminy, Patrice</au><au>Blanchette, Caty</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidural Corticosteroid Injections for Sciatica Due to Herniated Nucleus Pulposus</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1997-06-05</date><risdate>1997</risdate><volume>336</volume><issue>23</issue><spage>1634</spage><epage>1640</epage><pages>1634-1640</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Sciatica due to a herniated nucleus pulposus is an important medical and socioeconomic problem.
1
Although the majority of patients recover with conservative management, 10 to 15 percent need surgery.
2
Epidural corticosteroid injections were first used to treat sciatica in the early 1950s, as reported by Lièvre et al.
3
,
4
Of 12 controlled trials that have subsequently been reported, half found that the injections were more effective than the reference treatment,
5
–
10
and the other half found them to be no better or worse.
11
–
16
A critical analysis of these studies showed that most had methodologic deficiencies.
17
Reviews of the literature . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>9171065</pmid><doi>10.1056/NEJM199706053362303</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1997-06, Vol.336 (23), p.1634-1640 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Adult Anti-Inflammatory Agents - therapeutic use Biological and medical sciences Diseases of the osteoarticular system Diseases of the spine Double-Blind Method Female Humans Injections, Epidural - adverse effects Intervertebral Disc Displacement - complications Intervertebral Disc Displacement - surgery Male Medical disorders Medical procedures Medical research Medical sciences Methylprednisolone - analogs & derivatives Methylprednisolone - therapeutic use Sciatica - drug therapy Sciatica - etiology Sciatica - physiopathology Steroids Treatment Outcome |
| title | Epidural Corticosteroid Injections for Sciatica Due to Herniated Nucleus Pulposus |
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