Safety and Cost Effectiveness of High-Osmolality as Compared with Low-Osmolality Contrast Material in Patients Undergoing Cardiac Angiography
NUMEROUS studies have documented that in the performance of cardiac angiography, fewer hemodynamic and electrophysiologic changes result from the use of a nonionic, low-osmolality contrast agent than from the use of a high-osmolality contrast agent. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 A few studi...
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| Veröffentlicht in: | The New England journal of medicine 1992-02, Vol.326 (7), p.425-430 |
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| container_title | The New England journal of medicine |
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| creator | Steinberg, Earl P Moore, Richard D Powe, Neil R Gopalan, Ramana Davidoff, Amy J Litt, Marc Graziano, Sandra Brinker, Jeffrey A |
| description | NUMEROUS studies have documented that in the performance of cardiac angiography, fewer hemodynamic and electrophysiologic changes result from the use of a nonionic, low-osmolality contrast agent than from the use of a high-osmolality contrast agent.
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A few studies have suggested that high-osmolality agents that bind calcium avidly cause more hemodynamic and electrophysiologic perturbations than those that bind calcium less avidly.
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Considerable controversy remains, however, about the use of the two types of contrast agents in cardiac angiography, because those with low osmolality are substantially more expensive than those with high osmolality. The use of 200 ml of a high-osmolality contrast . . . |
| doi_str_mv | 10.1056/NEJM199202133260701 |
| format | Article |
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A few studies have suggested that high-osmolality agents that bind calcium avidly cause more hemodynamic and electrophysiologic perturbations than those that bind calcium less avidly.
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Considerable controversy remains, however, about the use of the two types of contrast agents in cardiac angiography, because those with low osmolality are substantially more expensive than those with high osmolality. The use of 200 ml of a high-osmolality contrast . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199202133260701</identifier><identifier>PMID: 1732769</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>BOSTON: Massachusetts Medical Society</publisher><subject>Age Factors ; Angina ; Angina, Unstable ; Angiography ; Biological and medical sciences ; Calcium ; Cardiac arrhythmia ; Contrast agents ; Contrast Media - adverse effects ; Contrast Media - economics ; Coronary Angiography ; Cost-Benefit Analysis ; Diatrizoate - adverse effects ; Diatrizoate - economics ; Double-Blind Method ; Drug toxicity and drugs side effects treatment ; Epidemiology ; Female ; General & Internal Medicine ; Heart ; Heart diseases ; Hospital costs ; Hospitals ; Humans ; Intubation ; Iohexol - adverse effects ; Iohexol - economics ; Life Sciences & Biomedicine ; Male ; Medical equipment ; Medical imaging ; Medical sciences ; Medicine, General & Internal ; Middle Aged ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Osmolar Concentration ; Patient safety ; Pharmacology. Drug treatments ; Process Assessment (Health Care) ; Risk Factors ; Science & Technology ; Side effects</subject><ispartof>The New England journal of medicine, 1992-02, Vol.326 (7), p.425-430</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright Massachusetts Medical Society Feb 13, 1992</rights><rights>Copyright Massachusetts Medical Society, Publishing Division Feb 13, 1992</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>129</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HD16400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c502t-ebff1b03c804cbb8eb99772ece66f5cbcd7e290c7961f93213b57a39411918a73</citedby><cites>FETCH-LOGICAL-c502t-ebff1b03c804cbb8eb99772ece66f5cbcd7e290c7961f93213b57a39411918a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199202133260701$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983445409?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,782,786,2761,2762,26110,27199,27931,27932,52389,54071,64392,64396,72476</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5220701$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1732769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinberg, Earl P</creatorcontrib><creatorcontrib>Moore, Richard D</creatorcontrib><creatorcontrib>Powe, Neil R</creatorcontrib><creatorcontrib>Gopalan, Ramana</creatorcontrib><creatorcontrib>Davidoff, Amy J</creatorcontrib><creatorcontrib>Litt, Marc</creatorcontrib><creatorcontrib>Graziano, Sandra</creatorcontrib><creatorcontrib>Brinker, Jeffrey A</creatorcontrib><title>Safety and Cost Effectiveness of High-Osmolality as Compared with Low-Osmolality Contrast Material in Patients Undergoing Cardiac Angiography</title><title>The New England journal of medicine</title><addtitle>NEW ENGL J MED</addtitle><addtitle>N Engl J Med</addtitle><description>NUMEROUS studies have documented that in the performance of cardiac angiography, fewer hemodynamic and electrophysiologic changes result from the use of a nonionic, low-osmolality contrast agent than from the use of a high-osmolality contrast agent.
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A few studies have suggested that high-osmolality agents that bind calcium avidly cause more hemodynamic and electrophysiologic perturbations than those that bind calcium less avidly.
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Considerable controversy remains, however, about the use of the two types of contrast agents in cardiac angiography, because those with low osmolality are substantially more expensive than those with high osmolality. The use of 200 ml of a high-osmolality contrast . . .</description><subject>Age Factors</subject><subject>Angina</subject><subject>Angina, Unstable</subject><subject>Angiography</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Cardiac arrhythmia</subject><subject>Contrast agents</subject><subject>Contrast Media - adverse effects</subject><subject>Contrast Media - economics</subject><subject>Coronary Angiography</subject><subject>Cost-Benefit Analysis</subject><subject>Diatrizoate - adverse effects</subject><subject>Diatrizoate - economics</subject><subject>Double-Blind Method</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General & Internal Medicine</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hospital costs</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Intubation</subject><subject>Iohexol - adverse effects</subject><subject>Iohexol - economics</subject><subject>Life Sciences & Biomedicine</subject><subject>Male</subject><subject>Medical equipment</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Medicine, General & Internal</subject><subject>Middle Aged</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Osmolar Concentration</subject><subject>Patient safety</subject><subject>Pharmacology. 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A few studies have suggested that high-osmolality agents that bind calcium avidly cause more hemodynamic and electrophysiologic perturbations than those that bind calcium less avidly.
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Considerable controversy remains, however, about the use of the two types of contrast agents in cardiac angiography, because those with low osmolality are substantially more expensive than those with high osmolality. The use of 200 ml of a high-osmolality contrast . . .</abstract><cop>BOSTON</cop><pub>Massachusetts Medical Society</pub><pmid>1732769</pmid><doi>10.1056/NEJM199202133260701</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 1992-02, Vol.326 (7), p.425-430 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| subjects | Age Factors Angina Angina, Unstable Angiography Biological and medical sciences Calcium Cardiac arrhythmia Contrast agents Contrast Media - adverse effects Contrast Media - economics Coronary Angiography Cost-Benefit Analysis Diatrizoate - adverse effects Diatrizoate - economics Double-Blind Method Drug toxicity and drugs side effects treatment Epidemiology Female General & Internal Medicine Heart Heart diseases Hospital costs Hospitals Humans Intubation Iohexol - adverse effects Iohexol - economics Life Sciences & Biomedicine Male Medical equipment Medical imaging Medical sciences Medicine, General & Internal Middle Aged Miscellaneous (drug allergy, mutagens, teratogens...) Osmolar Concentration Patient safety Pharmacology. Drug treatments Process Assessment (Health Care) Risk Factors Science & Technology Side effects |
| title | Safety and Cost Effectiveness of High-Osmolality as Compared with Low-Osmolality Contrast Material in Patients Undergoing Cardiac Angiography |
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