Structure‐Based Specific Detection and Inhibition of Monoamine Oxidases and Their Applications in Central Nervous System Diseases

Monoamine oxidases (MAOs) are the enzymes that catalyze the oxidation of monoamines, such as dopamine, norepinephrine, and serotonin, which serve as key neurotransmitters in the central nervous system (CNS). MAOs play important roles in maintaining the homeostasis of monoamines, and the aberrant exp...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2019-06, Vol.20 (12), p.1487-1497
Hauptverfasser:	Shi, Riri, Wu, Qiong, Xin, Chenqi, Yu, Houzhi, Lim, Kah‐Leong, Li, Xin, Shi, Zhenxiong, Zhang, Cheng‐Wu, Qian, Linghui, Li, Lin, Huang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	amines Animals Biogenic Monoamines - metabolism Cells, Cultured Central nervous system Central nervous system diseases Central Nervous System Diseases - drug therapy Disorders Dopamine enzymes Exploration Homeostasis Humans Inhibitors Mental disorders Monoamine Oxidase - chemistry Monoamine Oxidase - physiology Monoamine Oxidase Inhibitors - pharmacology Monoamines Nervous system Neurodegenerative diseases Neurological diseases Neurotransmitters Norepinephrine Oxidation Pathogenesis Probes Serotonin
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