A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation
Prophylaxis against stress ulcers has traditionally been recommended for the prevention of upper gastrointestinal bleeding in critically ill patients. 1 – 3 Recent natural-history studies have documented a very low incidence of bleeding, 4 however, suggesting that universal prophylaxis may not be wa...
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| Veröffentlicht in: | The New England journal of medicine 1998-03, Vol.338 (12), p.791-797 |
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| container_end_page | 797 |
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| container_title | The New England journal of medicine |
| container_volume | 338 |
| creator | Cook, Deborah Guyatt, Gordon Marshall, John Leasa, David Fuller, Hugh Hall, Richard Peters, Sharon Rutledge, Frank Griffith, Lauren McLellan, Allan Wood, Gordon Kirby, Ann Tweeddale, Martin Pagliarello, Joe Johnston, Richard |
| description | Prophylaxis against stress ulcers has traditionally been recommended for the prevention of upper gastrointestinal bleeding in critically ill patients.
1
–
3
Recent natural-history studies have documented a very low incidence of bleeding,
4
however, suggesting that universal prophylaxis may not be warranted.
5
–
7
Respiratory failure and coagulopathy are the strongest risk factors for clinically important gastrointestinal bleeding.
8
–
11
Randomized trials of prophylaxis against stress ulcers, as compared with no prophylaxis, indicate that histamine H
2
-receptor antagonists and antacids prevent clinically important gastrointestinal bleeding.
12
Observational studies have suggested, however, that a higher gastric pH is associated with gastric microbial growth,
13
tracheobronchial colonization, . . . |
| doi_str_mv | 10.1056/NEJM199803193381203 |
| format | Article |
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1
–
3
Recent natural-history studies have documented a very low incidence of bleeding,
4
however, suggesting that universal prophylaxis may not be warranted.
5
–
7
Respiratory failure and coagulopathy are the strongest risk factors for clinically important gastrointestinal bleeding.
8
–
11
Randomized trials of prophylaxis against stress ulcers, as compared with no prophylaxis, indicate that histamine H
2
-receptor antagonists and antacids prevent clinically important gastrointestinal bleeding.
12
Observational studies have suggested, however, that a higher gastric pH is associated with gastric microbial growth,
13
tracheobronchial colonization, . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199803193381203</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Biological and medical sciences ; Digestive system ; Drug therapy ; Hemorrhage ; Medical research ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>The New England journal of medicine, 1998-03, Vol.338 (12), p.791-797</ispartof><rights>Copyright © 1998 Massachusetts Medical Society. All rights reserved.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c539t-56ade5af9d4e1d9e1fbe12732c840f57358b28479ea865fc1c6433c7ed4a3bbc3</citedby><cites>FETCH-LOGICAL-c539t-56ade5af9d4e1d9e1fbe12732c840f57358b28479ea865fc1c6433c7ed4a3bbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199803193381203$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223951846?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,2759,2760,26103,27924,27925,52382,54064,64385,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2176039$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Cook, Deborah</creatorcontrib><creatorcontrib>Guyatt, Gordon</creatorcontrib><creatorcontrib>Marshall, John</creatorcontrib><creatorcontrib>Leasa, David</creatorcontrib><creatorcontrib>Fuller, Hugh</creatorcontrib><creatorcontrib>Hall, Richard</creatorcontrib><creatorcontrib>Peters, Sharon</creatorcontrib><creatorcontrib>Rutledge, Frank</creatorcontrib><creatorcontrib>Griffith, Lauren</creatorcontrib><creatorcontrib>McLellan, Allan</creatorcontrib><creatorcontrib>Wood, Gordon</creatorcontrib><creatorcontrib>Kirby, Ann</creatorcontrib><creatorcontrib>Tweeddale, Martin</creatorcontrib><creatorcontrib>Pagliarello, Joe</creatorcontrib><creatorcontrib>Johnston, Richard</creatorcontrib><title>A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation</title><title>The New England journal of medicine</title><description>Prophylaxis against stress ulcers has traditionally been recommended for the prevention of upper gastrointestinal bleeding in critically ill patients.
1
–
3
Recent natural-history studies have documented a very low incidence of bleeding,
4
however, suggesting that universal prophylaxis may not be warranted.
5
–
7
Respiratory failure and coagulopathy are the strongest risk factors for clinically important gastrointestinal bleeding.
8
–
11
Randomized trials of prophylaxis against stress ulcers, as compared with no prophylaxis, indicate that histamine H
2
-receptor antagonists and antacids prevent clinically important gastrointestinal bleeding.
12
Observational studies have suggested, however, that a higher gastric pH is associated with gastric microbial growth,
13
tracheobronchial colonization, . . .</description><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Drug therapy</subject><subject>Hemorrhage</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Pharmacology. 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1
–
3
Recent natural-history studies have documented a very low incidence of bleeding,
4
however, suggesting that universal prophylaxis may not be warranted.
5
–
7
Respiratory failure and coagulopathy are the strongest risk factors for clinically important gastrointestinal bleeding.
8
–
11
Randomized trials of prophylaxis against stress ulcers, as compared with no prophylaxis, indicate that histamine H
2
-receptor antagonists and antacids prevent clinically important gastrointestinal bleeding.
12
Observational studies have suggested, however, that a higher gastric pH is associated with gastric microbial growth,
13
tracheobronchial colonization, . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><doi>10.1056/NEJM199803193381203</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1998-03, Vol.338 (12), p.791-797 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_223951846 |
| source | EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Biological and medical sciences Digestive system Drug therapy Hemorrhage Medical research Medical sciences Pharmacology. Drug treatments |
| title | A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation |
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