Leukotriene-Receptor Inhibition for the Treatment of Systemic Mastocytosis
To the Editor: Systemic mastocytosis is an uncommon and potentially misdiagnosed condition. Its hallmark is the accumulation and abnormal proliferation of mast cells in various tissues. A two-month-old boy was referred to our facility with numerous bullae on the skin and unilateral periorbital cellu...
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| Veröffentlicht in: | The New England journal of medicine 2004-02, Vol.350 (7), p.735-736 |
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| container_title | The New England journal of medicine |
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| creator | Tolar, Jakub Tope, Whitney D Neglia, Joseph P |
| description | To the Editor:
Systemic mastocytosis is an uncommon and potentially misdiagnosed condition. Its hallmark is the accumulation and abnormal proliferation of mast cells in various tissues.
A two-month-old boy was referred to our facility with numerous bullae on the skin and unilateral periorbital cellulitis. The child was inconsolable, and his skin lesions, which had been present since birth, progressed into subcutaneous nodules, plaques, and tumors, which were excoriated. He had hepatomegaly and wheezing. Findings on examination of biopsy specimens of the skin and bone marrow were consistent with the diagnosis of systemic mastocytosis. There were no bony lesions, and there . . . |
| doi_str_mv | 10.1056/NEJM200402123500723 |
| format | Article |
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Systemic mastocytosis is an uncommon and potentially misdiagnosed condition. Its hallmark is the accumulation and abnormal proliferation of mast cells in various tissues.
A two-month-old boy was referred to our facility with numerous bullae on the skin and unilateral periorbital cellulitis. The child was inconsolable, and his skin lesions, which had been present since birth, progressed into subcutaneous nodules, plaques, and tumors, which were excoriated. He had hepatomegaly and wheezing. Findings on examination of biopsy specimens of the skin and bone marrow were consistent with the diagnosis of systemic mastocytosis. There were no bony lesions, and there . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200402123500723</identifier><identifier>PMID: 14960756</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Acetates - therapeutic use ; Anti-Inflammatory Agents - therapeutic use ; Drug Therapy, Combination ; Humans ; Infant ; Leukotriene Antagonists - therapeutic use ; Male ; Mastocytosis, Systemic - drug therapy ; Prednisone - therapeutic use ; Quinolines - therapeutic use</subject><ispartof>The New England journal of medicine, 2004-02, Vol.350 (7), p.735-736</ispartof><rights>Copyright © 2004 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-aa1cf3a4dcd108054da7d53f43c14d3240a52eeb8d0967ebb1cc5a61810f94973</citedby><cites>FETCH-LOGICAL-c481t-aa1cf3a4dcd108054da7d53f43c14d3240a52eeb8d0967ebb1cc5a61810f94973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200402123500723$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/223948633?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,2745,2746,26082,27903,27904,52361,54043,64362,64366,72216</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14960756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tolar, Jakub</creatorcontrib><creatorcontrib>Tope, Whitney D</creatorcontrib><creatorcontrib>Neglia, Joseph P</creatorcontrib><title>Leukotriene-Receptor Inhibition for the Treatment of Systemic Mastocytosis</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Systemic mastocytosis is an uncommon and potentially misdiagnosed condition. Its hallmark is the accumulation and abnormal proliferation of mast cells in various tissues.
A two-month-old boy was referred to our facility with numerous bullae on the skin and unilateral periorbital cellulitis. The child was inconsolable, and his skin lesions, which had been present since birth, progressed into subcutaneous nodules, plaques, and tumors, which were excoriated. He had hepatomegaly and wheezing. Findings on examination of biopsy specimens of the skin and bone marrow were consistent with the diagnosis of systemic mastocytosis. There were no bony lesions, and there . . .</description><subject>Acetates - therapeutic use</subject><subject>Anti-Inflammatory Agents - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukotriene Antagonists - therapeutic use</subject><subject>Male</subject><subject>Mastocytosis, Systemic - drug therapy</subject><subject>Prednisone - therapeutic use</subject><subject>Quinolines - therapeutic use</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kM1Lw0AQxRdRbKz-BYIErxKd_crHUUrVllZB6zlsNrM01WTr7ubQ_95IC17EOcww8HvvwSPkksItBZnePU_nSwYggFHGJUDG-BGJqOQ8EQLSYxIBsDwRWcFH5Mz7DQxDRXFKRsNOIZNpROYL7D9scA12mLyixm2wLp5166ZqQmO72AxvWGO8cqhCi12IrYnfdj5g2-h4qXywehesb_w5OTHq0-PF4Y7J-8N0NXlKFi-Ps8n9ItEipyFRimrDlah1TSEHKWqV1ZIbwTUVNWcClGSIVV5DkWZYVVRrqVKaUzCFKDI-Jtd7362zXz36UG5s77ohsmSMFyJPOR8gvoe0s947NOXWNa1yu5JC-VNf-Ud9g-rqYN1XLda_mkNfA3CzB9rWlx1u2n_tvgEmyXbH</recordid><startdate>20040212</startdate><enddate>20040212</enddate><creator>Tolar, Jakub</creator><creator>Tope, Whitney D</creator><creator>Neglia, Joseph P</creator><general>Massachusetts Medical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20040212</creationdate><title>Leukotriene-Receptor Inhibition for the Treatment of Systemic Mastocytosis</title><author>Tolar, Jakub ; Tope, Whitney D ; Neglia, Joseph P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-aa1cf3a4dcd108054da7d53f43c14d3240a52eeb8d0967ebb1cc5a61810f94973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetates - therapeutic use</topic><topic>Anti-Inflammatory Agents - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukotriene Antagonists - therapeutic use</topic><topic>Male</topic><topic>Mastocytosis, Systemic - drug therapy</topic><topic>Prednisone - therapeutic use</topic><topic>Quinolines - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tolar, Jakub</creatorcontrib><creatorcontrib>Tope, Whitney D</creatorcontrib><creatorcontrib>Neglia, Joseph P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tolar, Jakub</au><au>Tope, Whitney D</au><au>Neglia, Joseph P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukotriene-Receptor Inhibition for the Treatment of Systemic Mastocytosis</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2004-02-12</date><risdate>2004</risdate><volume>350</volume><issue>7</issue><spage>735</spage><epage>736</epage><pages>735-736</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>To the Editor:
Systemic mastocytosis is an uncommon and potentially misdiagnosed condition. Its hallmark is the accumulation and abnormal proliferation of mast cells in various tissues.
A two-month-old boy was referred to our facility with numerous bullae on the skin and unilateral periorbital cellulitis. The child was inconsolable, and his skin lesions, which had been present since birth, progressed into subcutaneous nodules, plaques, and tumors, which were excoriated. He had hepatomegaly and wheezing. Findings on examination of biopsy specimens of the skin and bone marrow were consistent with the diagnosis of systemic mastocytosis. There were no bony lesions, and there . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>14960756</pmid><doi>10.1056/NEJM200402123500723</doi><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acetates - therapeutic use Anti-Inflammatory Agents - therapeutic use Drug Therapy, Combination Humans Infant Leukotriene Antagonists - therapeutic use Male Mastocytosis, Systemic - drug therapy Prednisone - therapeutic use Quinolines - therapeutic use |
| title | Leukotriene-Receptor Inhibition for the Treatment of Systemic Mastocytosis |
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