U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection

In this randomized trial involving 454 patients with pleural infections that required antibiotic therapy and chest-tube drainage, there was no benefit from the use of intrapleural streptokinase in terms of survival, the need for surgery, the length of the hospital stay, or the resolution of radiogra...

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Veröffentlicht in:	The New England journal of medicine 2005-03, Vol.352 (9), p.865-874
Hauptverfasser:	Maskell, Nicholas A, Davies, Robert J.O, Davies, Christopher W.H, Nunn, Andrew J, Hedley, Emma L, Gleeson, Fergus V, Miller, Robert, Gabe, Rhian, Rees, Glyn L, Peto, Timothy E.A, Woodhead, Mark A, Lane, Donald J, Darbyshire, Janet H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - therapeutic use Bacterial Infections - diagnostic imaging Bacterial Infections - drug therapy Bacterial Infections - mortality Bacterial Infections - surgery Biological and medical sciences Clinical outcomes Clinical trials Combined Modality Therapy Community-Acquired Infections - drug therapy Cross Infection - drug therapy Double-Blind Method Drainage Empyema, Pleural - drug therapy Empyema, Pleural - mortality Empyema, Pleural - surgery Female Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use General aspects Humans Infections Instillation, Drug Length of Stay Lung - diagnostic imaging Male Medical sciences Middle Aged Pleural Diseases - diagnostic imaging Pleural Diseases - drug therapy Pleural Diseases - mortality Pleural Diseases - surgery Pneumonia - complications Radiography Respiratory diseases Streptokinase - adverse effects Streptokinase - therapeutic use Surgery United Kingdom
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