Transient Enhanced Uptake of 123I-Metaiodobenzylguanidine in the Contralateral Adrenal Region after Resection of an Adrenal Pheochromocytoma
To the Editor: Pheochromocytomas are tumors of chromaffin tissue that may secrete catecholamines continuously or intermittently, thereby causing sustained or paroxysmal hypertension, respectively. After removal of the primary tumor, 6 to 23 percent of patients may have recurrences, and follow-up is...
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| Veröffentlicht in: | The New England journal of medicine 2000-05, Vol.342 (19), p.1450-1450 |
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| container_issue | 19 |
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| container_title | The New England journal of medicine |
| container_volume | 342 |
| creator | Boersma, Hendrikus H Wensing, Johanna W Kho, T. Liang de Brauw, L. Maurits Liem, Ing Han van Kroonenburgh, Marinus J.P.G |
| description | To the Editor:
Pheochromocytomas are tumors of chromaffin tissue that may secrete catecholamines continuously or intermittently, thereby causing sustained or paroxysmal hypertension, respectively. After removal of the primary tumor, 6 to 23 percent of patients may have recurrences, and follow-up is therefore essential.
1
The tests used for this purpose include measurements of 24-hour urinary catecholamine secretion and the clonidine suppression test. A specific method for detecting chromaffin in tumors is
123
I-metaiodobenzylguanidine (
123
I-MIBG) scintigraphy.
2
In vitro experiments suggest that MIBG accumulates in adrenergic tissue by means of the norepinephrine-uptake transporter.
3
We describe a patient with a pheochromocytoma in whom
123
I-MIBG . . . |
| doi_str_mv | 10.1056/NEJM200005113421915 |
| format | Article |
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Pheochromocytomas are tumors of chromaffin tissue that may secrete catecholamines continuously or intermittently, thereby causing sustained or paroxysmal hypertension, respectively. After removal of the primary tumor, 6 to 23 percent of patients may have recurrences, and follow-up is therefore essential.
1
The tests used for this purpose include measurements of 24-hour urinary catecholamine secretion and the clonidine suppression test. A specific method for detecting chromaffin in tumors is
123
I-metaiodobenzylguanidine (
123
I-MIBG) scintigraphy.
2
In vitro experiments suggest that MIBG accumulates in adrenergic tissue by means of the norepinephrine-uptake transporter.
3
We describe a patient with a pheochromocytoma in whom
123
I-MIBG . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM200005113421915</identifier><identifier>PMID: 10809616</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>3-Iodobenzylguanidine - pharmacokinetics ; Adrenal Gland Neoplasms - diagnostic imaging ; Adrenal Gland Neoplasms - surgery ; Adrenal Glands - diagnostic imaging ; Adrenal Glands - metabolism ; Adrenalectomy ; Female ; Humans ; Middle Aged ; Pheochromocytoma - diagnostic imaging ; Pheochromocytoma - surgery ; Radionuclide Imaging ; Radiopharmaceuticals - pharmacokinetics</subject><ispartof>The New England journal of medicine, 2000-05, Vol.342 (19), p.1450-1450</ispartof><rights>Copyright © 2000 Massachusetts Medical Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM200005113421915$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJM200005113421915$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10809616$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boersma, Hendrikus H</creatorcontrib><creatorcontrib>Wensing, Johanna W</creatorcontrib><creatorcontrib>Kho, T. Liang</creatorcontrib><creatorcontrib>de Brauw, L. Maurits</creatorcontrib><creatorcontrib>Liem, Ing Han</creatorcontrib><creatorcontrib>van Kroonenburgh, Marinus J.P.G</creatorcontrib><title>Transient Enhanced Uptake of 123I-Metaiodobenzylguanidine in the Contralateral Adrenal Region after Resection of an Adrenal Pheochromocytoma</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>To the Editor:
Pheochromocytomas are tumors of chromaffin tissue that may secrete catecholamines continuously or intermittently, thereby causing sustained or paroxysmal hypertension, respectively. After removal of the primary tumor, 6 to 23 percent of patients may have recurrences, and follow-up is therefore essential.
1
The tests used for this purpose include measurements of 24-hour urinary catecholamine secretion and the clonidine suppression test. A specific method for detecting chromaffin in tumors is
123
I-metaiodobenzylguanidine (
123
I-MIBG) scintigraphy.
2
In vitro experiments suggest that MIBG accumulates in adrenergic tissue by means of the norepinephrine-uptake transporter.
3
We describe a patient with a pheochromocytoma in whom
123
I-MIBG . . .</description><subject>3-Iodobenzylguanidine - pharmacokinetics</subject><subject>Adrenal Gland Neoplasms - diagnostic imaging</subject><subject>Adrenal Gland Neoplasms - surgery</subject><subject>Adrenal Glands - diagnostic imaging</subject><subject>Adrenal Glands - metabolism</subject><subject>Adrenalectomy</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Pheochromocytoma - diagnostic imaging</subject><subject>Pheochromocytoma - surgery</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals - pharmacokinetics</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkUtPwzAMxyMEYmPwCZBQxBUV4qTNmuM0jZfGQ2icq7Rx1441GW12GJ-BD02mDU74YMv2T3_5Qcg5sGtgibx5njw-cRYsARAxBwXJAelDIkQUx0wekj5jPI3ioRI9ctJ1iy0LsTomPWApUxJkn3zPWm27Gq2nE1tpW6Ch7yuvP5C6kgIXD9ETel0743K0X5vlfK1tbWqLtLbUV0jHzvpWL7XH4OnItGhDfMN57SzVZSiHpMPCb_Ogqe0f9FqhK6rWNa7YeNfoU3JU6mWHZ_s4ILPbyWx8H01f7h7Go2lUAU9kBKqUsZZpblQiSgmALC7AhN0M41CmiuXKKAZFjsDKeIhDSDlwLZKUSyPEgFzuZFet-1xj57OFW7dhoC7jXCghZHADcrGH1nmDJlu1daPbTfZ7ugBc7YCm6TKLiya0su1jsn8eI34AAaR9Zw</recordid><startdate>20000511</startdate><enddate>20000511</enddate><creator>Boersma, Hendrikus H</creator><creator>Wensing, Johanna W</creator><creator>Kho, T. 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Liang ; de Brauw, L. Maurits ; Liem, Ing Han ; van Kroonenburgh, Marinus J.P.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h1256-19f64a68bd953f611e04c1d014d021f890b9d901cbe10f47e718212a35826d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>3-Iodobenzylguanidine - pharmacokinetics</topic><topic>Adrenal Gland Neoplasms - diagnostic imaging</topic><topic>Adrenal Gland Neoplasms - surgery</topic><topic>Adrenal Glands - diagnostic imaging</topic><topic>Adrenal Glands - metabolism</topic><topic>Adrenalectomy</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Pheochromocytoma - diagnostic imaging</topic><topic>Pheochromocytoma - surgery</topic><topic>Radionuclide Imaging</topic><topic>Radiopharmaceuticals - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boersma, Hendrikus H</creatorcontrib><creatorcontrib>Wensing, Johanna W</creatorcontrib><creatorcontrib>Kho, T. 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Pheochromocytomas are tumors of chromaffin tissue that may secrete catecholamines continuously or intermittently, thereby causing sustained or paroxysmal hypertension, respectively. After removal of the primary tumor, 6 to 23 percent of patients may have recurrences, and follow-up is therefore essential.
1
The tests used for this purpose include measurements of 24-hour urinary catecholamine secretion and the clonidine suppression test. A specific method for detecting chromaffin in tumors is
123
I-metaiodobenzylguanidine (
123
I-MIBG) scintigraphy.
2
In vitro experiments suggest that MIBG accumulates in adrenergic tissue by means of the norepinephrine-uptake transporter.
3
We describe a patient with a pheochromocytoma in whom
123
I-MIBG . . .</abstract><cop>United States</cop><pub>Massachusetts Medical Society</pub><pmid>10809616</pmid><doi>10.1056/NEJM200005113421915</doi><tpages>1</tpages></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2000-05, Vol.342 (19), p.1450-1450 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library; New England Journal of Medicine |
| subjects | 3-Iodobenzylguanidine - pharmacokinetics Adrenal Gland Neoplasms - diagnostic imaging Adrenal Gland Neoplasms - surgery Adrenal Glands - diagnostic imaging Adrenal Glands - metabolism Adrenalectomy Female Humans Middle Aged Pheochromocytoma - diagnostic imaging Pheochromocytoma - surgery Radionuclide Imaging Radiopharmaceuticals - pharmacokinetics |
| title | Transient Enhanced Uptake of 123I-Metaiodobenzylguanidine in the Contralateral Adrenal Region after Resection of an Adrenal Pheochromocytoma |
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