Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease

In chronic granulomatous disease of childhood, killing of microorganisms is impaired because of defects in the production of hydrogen peroxide. In this controlled study, 39 patients were treated in alternate years with either itraconazole or placebo, once per day. There were seven serious infections...

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Veröffentlicht in:	The New England journal of medicine 2003-06, Vol.348 (24), p.2416-2422
Hauptverfasser:	Gallin, John I, Alling, David W, Malech, Harry L, Wesley, Robert, Koziol, Deloris, Marciano, Beatriz, Eisenstein, Eli M, Turner, Maria L, DeCarlo, Ellen S, Starling, Judith M, Holland, Steven M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - adverse effects Antifungal Agents - blood Antifungal Agents - therapeutic use Bacterial infections Biological and medical sciences Child Child, Preschool Cross-Over Studies Double-Blind Method Female Granulomatous Disease, Chronic - complications Granulomatous Disease, Chronic - drug therapy Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Interferon Itraconazole - adverse effects Itraconazole - blood Itraconazole - therapeutic use Male Medical sciences Middle Aged Mortality Mycoses - etiology Mycoses - prevention & control Patient Compliance Pharmacology. Drug treatments Rare Diseases - drug therapy Stem cells Transplants & implants
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