A Comparison of Two Intensities of Warfarin for the Prevention of Recurrent Thrombosis in Patients with the Antiphospholipid Antibody Syndrome

Warfarin can prevent recurrent thrombosis in patients with the antiphospholipid antibody syndrome, but the intensity of anticoagulation is an unsettled matter. In this randomized trial, patients with the syndrome were assigned to moderate- or high-intensity warfarin. The high-intensity regimen was n...

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Veröffentlicht in:	The New England journal of medicine 2003-09, Vol.349 (12), p.1133-1138
Hauptverfasser:	Crowther, Mark A, Ginsberg, Jeff S, Julian, Jim, Denburg, Judah, Hirsh, Jack, Douketis, James, Laskin, Carl, Fortin, Paul, Anderson, David, Kearon, Clive, Clarke, Ann, Geerts, William, Forgie, Melissa, Green, David, Costantini, Lorrie, Yacura, Wendy, Wilson, Sarah, Gent, Michael, Kovacs, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Antiphospholipid - blood Anticoagulants Anticoagulants - administration & dosage Anticoagulants - adverse effects Antiphospholipid Syndrome - blood Antiphospholipid Syndrome - complications Antiphospholipid Syndrome - drug therapy Biological and medical sciences Blood clots Blood. Blood coagulation. Reticuloendothelial system Double-Blind Method Drug therapy Female Follow-Up Studies Hemorrhage - chemically induced Humans International Normalized Ratio Male Medical sciences Middle Aged Myocardial Infarction - prevention & control Pharmacology. Drug treatments Pulmonary Embolism - prevention & control Secondary Prevention Stroke Venous Thrombosis - prevention & control Warfarin - administration & dosage Warfarin - adverse effects
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