Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1Brief Report
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We...
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| Veröffentlicht in: | The New England journal of medicine 2008-06, Vol.358 (25), p.2698 |
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| container_issue | 25 |
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| container_title | The New England journal of medicine |
| container_volume | 358 |
| creator | Hunder, Naomi N Wallen, Herschel Cao, Jianhong Hendricks, Deborah W Reilly, John Z Rodmyre, Rebecca Jungbluth, Achim Gnjatic, Sacha Thompson, John A Yee, Cassian |
| description | We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1. |
| doi_str_mv | 10.1056/NEJMoa0800251 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | The New England journal of medicine, 2008-06, Vol.358 (25), p.2698 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_proquest_journals_223922383 |
| source | EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Biotechnology Cellular biology Cloning Immunology Leukocytes Medical research Skin cancer |
| title | Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1Brief Report |
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