A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease

In this large, randomized trial, the investigators compared outcomes in patients with chronic obstructive pulmonary disease (COPD) treated with once-daily inhalation of tiotropium or placebo. There was no benefit of treatment on the rate of loss of lung function over time, although benefits were obs...

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Veröffentlicht in:	The New England journal of medicine 2008-10, Vol.359 (15), p.1543-1554
Hauptverfasser:	Tashkin, Donald P, Celli, Bartolome, Senn, Stephen, Burkhart, Deborah, Kesten, Steven, Menjoge, Shailendra, Decramer, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Bronchodilator Agents - adverse effects Bronchodilator Agents - pharmacology Bronchodilator Agents - therapeutic use Cholinergic Antagonists - adverse effects Cholinergic Antagonists - pharmacology Cholinergic Antagonists - therapeutic use Chronic obstructive pulmonary disease Disease Progression Double-Blind Method Drug therapy Drug Therapy, Combination Female Forced Expiratory Volume - drug effects General aspects Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Mortality Proportional Hazards Models Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - mortality Pulmonary Disease, Chronic Obstructive - physiopathology Quality of Life Scopolamine Derivatives - adverse effects Scopolamine Derivatives - pharmacology Scopolamine Derivatives - therapeutic use Tiotropium Bromide Vital Capacity - drug effects
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