Consistent and significant inhibition of human immunodeficiency virus type 1 envelope-mediated membrane fusion by (beta)-chemokines (RANTES) in primary human macrophages

Infection and entry of CD4(+) cells by human immunodeficiency virus type 1 (HIV-1) requires a coreceptor molecule, which, in concert with CD4, interacts with the viral envelope glycoprotein (Env), leading to membrane fusion. The principal coreceptors are the CCR5 and CXCR4 chemokine receptors. The s...

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Veröffentlicht in:	The Journal of infectious diseases 2000-07, Vol.182 (1), p.68
Hauptverfasser:	Stantchev, Tzanko S, Broder, Christopher C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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