Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation

This large trial of acute lymphoblastic leukemia in children aimed to determine whether intensive systemic and intrathecal chemotherapy could obviate the need for prophylactic central nervous system irradiation, which is associated with distressing late complications. The results show that, with met...

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Veröffentlicht in:	The New England journal of medicine 2009-06, Vol.360 (26), p.2730-2741
Hauptverfasser:	Pui, Ching-Hon, Campana, Dario, Pei, Deqing, Bowman, W. Paul, Sandlund, John T, Kaste, Sue C, Ribeiro, Raul C, Rubnitz, Jeffrey E, Raimondi, Susana C, Onciu, Mihaela, Coustan-Smith, Elaine, Kun, Larry E, Jeha, Sima, Cheng, Cheng, Howard, Scott C, Simmons, Vickey, Bayles, Amy, Metzger, Monika L, Boyett, James M, Leung, Wing, Handgretinger, Rupert, Downing, James R, Evans, William E, Relling, Mary V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asparaginase - administration & dosage Asparaginase - adverse effects Biological and medical sciences Central Nervous System Neoplasms - drug therapy Child Child, Preschool Children & youth Combined Modality Therapy Cranial Irradiation Cyclophosphamide - administration & dosage Daunorubicin - administration & dosage Dexamethasone - administration & dosage Drug therapy General aspects Heart attacks Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Mercaptopurine - administration & dosage Methotrexate - adverse effects Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Remission Induction - methods Risk Factors Secondary Prevention Survival Analysis Treatment Outcome Vincristine - administration & dosage
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