Epithelial ovarian cancer stem‑like cells are resistant to the cellular lysis of cytokine‑induced killer cells via HIF1A‑mediated downregulation of ICAM‑1

Epithelial ovarian cancer (EOC) is the most lethal of all gynecologic tumors. Cancer spheroid culture is a widely used model to study cancer stem cells. Previous studies have demonstrated the effectiveness of cytokine‑induced killer (CIK) cell‑based therapies against cancer and cancer stem cells. Ho...

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Veröffentlicht in:	International journal of oncology 2019-07, Vol.55 (1), p.179-190
Hauptverfasser:	Bu, Shixia, Li, Boning, Wang, Qian, Gu, Tingting, Dong, Qianggang, Miao, Xiaofei, Lai, Dongmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis Antibodies Antigens Blood Bone morphogenetic proteins Cancer research Cancer therapies Carcinoma, Ovarian Epithelial - genetics Carcinoma, Ovarian Epithelial - metabolism Carcinoma, Ovarian Epithelial - therapy Cell Line, Tumor Cell Proliferation Cobalt compounds Cytokine-Induced Killer Cells - cytology Cytokine-Induced Killer Cells - transplantation Cytokines Down-Regulation Drug Resistance, Neoplasm EDTA Female Gene Expression Regulation, Neoplastic Growth factors Health aspects Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Killer cells Medical prognosis Medical research Metastasis Neomycin Neoplastic Stem Cells - cytology Neoplastic Stem Cells - metabolism Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - therapy Penicillin RNA Scientific equipment industry Spheroids Stem cell research Stem cell transplantation Stem cells Studies Transforming growth factors Tumor necrosis factor-TNF Tumors
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