Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues
Fatty liver disease (FLD) is one of the major hazards to human health, but effectively and accurately detecting it during its various phases remains challenging. To address this issue, in the current work, four BODIPY analogues ( 01B-04B ) with different donor/acceptor groups were rationally designe...
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| Veröffentlicht in: | Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-06, Vol.7 (23), p.374-379 |
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| container_title | Journal of materials chemistry. B, Materials for biology and medicine |
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| creator | Shao, Tao Liu, Tianyan Liu, Hui Zhang, Mingzhu Shen, Yu Gao, Awei Tian, Xiaohe Zhang, Qiong Wu, Jieying Tian, Yupeng |
| description | Fatty liver disease (FLD) is one of the major hazards to human health, but effectively and accurately detecting it during its various phases remains challenging. To address this issue, in the current work, four BODIPY analogues (
01B-04B
) with different donor/acceptor groups were rationally designed. Photophysical and theoretical studies demonstrated an obvious intramolecular charge transfer (ICT) in
03B
, with two-photon action cross-sections up to 198 GM in the near-infrared region. An initial
in vitro
assessment indicated that
03B
could interact with the lipid substances with a significant fluorescence enhancement. Due to its high biocompatibility, lipid affinity, and sensitivity,
03B
could target model 3T3-L1 cells at various FLD-induced stages. Furthermore, an
in vivo
study demonstrated the ability to use
03B
to clearly distinguish FLD tissue and display a lesion
in situ
. These results offered a promising optical tool for evaluating FLD at various phases and monitoring its dynamics at the sub-cellular level.
03B
can target 3T3-L1 model cells at different fatty liver disease (FLD)-induced stages and clearly distinguish FLD tissue and display a lesion
in situ
. |
| doi_str_mv | 10.1039/c9tb00421a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2238867064</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2238867064</sourcerecordid><originalsourceid>FETCH-LOGICAL-c307t-350d7d267657e2570f3b140ffa2999a20b7f3ee556df7e532b010980a20394083</originalsourceid><addsrcrecordid>eNp9kU1LAzEQhhdRsNRevAsRb8LqJNndbI5t_SoU6qGCnpbsbtKmbDdrkioFf7zRar2Zy7zMPHlnmImiUwxXGCi_rrgvARKCxUHUI5BCzFKcH-41PB9HA-dWEF6Os5wmvehjUsvWa6Ur4bVpkVFICe-3qNFv0qJaOymcRMIHGRJBOi8W0qGN0-0C-XcTd0vjw09ROmO7XxNvdbeU7bYRa93KuAwmNRrNbiaPL0i0ojGLjXQn0ZESjZODn9iPnu5u5-OHeDq7n4yH07iiwHxMU6hZTTKWpUySlIGiJU5AKUE454JAyRSVMk2zWjGZUlICBp5DqFCeQE770cXOt7PmNfT1xcpsbJjCFYTQPM8YZEmgLndUZY1zVqqis3ot7LbAUHwtuBjz-eh7wcMAn-9g66o993eAoqtVYM7-Y-gnJHmDjA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2238867064</pqid></control><display><type>article</type><title>Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues</title><source>Royal Society Of Chemistry Journals</source><creator>Shao, Tao ; Liu, Tianyan ; Liu, Hui ; Zhang, Mingzhu ; Shen, Yu ; Gao, Awei ; Tian, Xiaohe ; Zhang, Qiong ; Wu, Jieying ; Tian, Yupeng</creator><creatorcontrib>Shao, Tao ; Liu, Tianyan ; Liu, Hui ; Zhang, Mingzhu ; Shen, Yu ; Gao, Awei ; Tian, Xiaohe ; Zhang, Qiong ; Wu, Jieying ; Tian, Yupeng</creatorcontrib><description>Fatty liver disease (FLD) is one of the major hazards to human health, but effectively and accurately detecting it during its various phases remains challenging. To address this issue, in the current work, four BODIPY analogues (
01B-04B
) with different donor/acceptor groups were rationally designed. Photophysical and theoretical studies demonstrated an obvious intramolecular charge transfer (ICT) in
03B
, with two-photon action cross-sections up to 198 GM in the near-infrared region. An initial
in vitro
assessment indicated that
03B
could interact with the lipid substances with a significant fluorescence enhancement. Due to its high biocompatibility, lipid affinity, and sensitivity,
03B
could target model 3T3-L1 cells at various FLD-induced stages. Furthermore, an
in vivo
study demonstrated the ability to use
03B
to clearly distinguish FLD tissue and display a lesion
in situ
. These results offered a promising optical tool for evaluating FLD at various phases and monitoring its dynamics at the sub-cellular level.
03B
can target 3T3-L1 model cells at different fatty liver disease (FLD)-induced stages and clearly distinguish FLD tissue and display a lesion
in situ
.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/c9tb00421a</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Biocompatibility ; Charge transfer ; Crystallography ; Fatty liver ; Fluorescence ; Health hazards ; In vivo methods and tests ; Lipids ; Liver ; Liver diseases ; Photon absorption</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2019-06, Vol.7 (23), p.374-379</ispartof><rights>Copyright Royal Society of Chemistry 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c307t-350d7d267657e2570f3b140ffa2999a20b7f3ee556df7e532b010980a20394083</citedby><cites>FETCH-LOGICAL-c307t-350d7d267657e2570f3b140ffa2999a20b7f3ee556df7e532b010980a20394083</cites><orcidid>0000-0002-9023-2555 ; 0000-0001-7603-546X ; 0000-0002-5360-3951 ; 0000-0002-2294-3945 ; 0000-0003-2811-2066</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Shao, Tao</creatorcontrib><creatorcontrib>Liu, Tianyan</creatorcontrib><creatorcontrib>Liu, Hui</creatorcontrib><creatorcontrib>Zhang, Mingzhu</creatorcontrib><creatorcontrib>Shen, Yu</creatorcontrib><creatorcontrib>Gao, Awei</creatorcontrib><creatorcontrib>Tian, Xiaohe</creatorcontrib><creatorcontrib>Zhang, Qiong</creatorcontrib><creatorcontrib>Wu, Jieying</creatorcontrib><creatorcontrib>Tian, Yupeng</creatorcontrib><title>Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><description>Fatty liver disease (FLD) is one of the major hazards to human health, but effectively and accurately detecting it during its various phases remains challenging. To address this issue, in the current work, four BODIPY analogues (
01B-04B
) with different donor/acceptor groups were rationally designed. Photophysical and theoretical studies demonstrated an obvious intramolecular charge transfer (ICT) in
03B
, with two-photon action cross-sections up to 198 GM in the near-infrared region. An initial
in vitro
assessment indicated that
03B
could interact with the lipid substances with a significant fluorescence enhancement. Due to its high biocompatibility, lipid affinity, and sensitivity,
03B
could target model 3T3-L1 cells at various FLD-induced stages. Furthermore, an
in vivo
study demonstrated the ability to use
03B
to clearly distinguish FLD tissue and display a lesion
in situ
. These results offered a promising optical tool for evaluating FLD at various phases and monitoring its dynamics at the sub-cellular level.
03B
can target 3T3-L1 model cells at different fatty liver disease (FLD)-induced stages and clearly distinguish FLD tissue and display a lesion
in situ
.</description><subject>Biocompatibility</subject><subject>Charge transfer</subject><subject>Crystallography</subject><subject>Fatty liver</subject><subject>Fluorescence</subject><subject>Health hazards</subject><subject>In vivo methods and tests</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>Photon absorption</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kU1LAzEQhhdRsNRevAsRb8LqJNndbI5t_SoU6qGCnpbsbtKmbDdrkioFf7zRar2Zy7zMPHlnmImiUwxXGCi_rrgvARKCxUHUI5BCzFKcH-41PB9HA-dWEF6Os5wmvehjUsvWa6Ur4bVpkVFICe-3qNFv0qJaOymcRMIHGRJBOi8W0qGN0-0C-XcTd0vjw09ROmO7XxNvdbeU7bYRa93KuAwmNRrNbiaPL0i0ojGLjXQn0ZESjZODn9iPnu5u5-OHeDq7n4yH07iiwHxMU6hZTTKWpUySlIGiJU5AKUE454JAyRSVMk2zWjGZUlICBp5DqFCeQE770cXOt7PmNfT1xcpsbJjCFYTQPM8YZEmgLndUZY1zVqqis3ot7LbAUHwtuBjz-eh7wcMAn-9g66o993eAoqtVYM7-Y-gnJHmDjA</recordid><startdate>20190612</startdate><enddate>20190612</enddate><creator>Shao, Tao</creator><creator>Liu, Tianyan</creator><creator>Liu, Hui</creator><creator>Zhang, Mingzhu</creator><creator>Shen, Yu</creator><creator>Gao, Awei</creator><creator>Tian, Xiaohe</creator><creator>Zhang, Qiong</creator><creator>Wu, Jieying</creator><creator>Tian, Yupeng</creator><general>Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><orcidid>https://orcid.org/0000-0002-9023-2555</orcidid><orcidid>https://orcid.org/0000-0001-7603-546X</orcidid><orcidid>https://orcid.org/0000-0002-5360-3951</orcidid><orcidid>https://orcid.org/0000-0002-2294-3945</orcidid><orcidid>https://orcid.org/0000-0003-2811-2066</orcidid></search><sort><creationdate>20190612</creationdate><title>Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues</title><author>Shao, Tao ; Liu, Tianyan ; Liu, Hui ; Zhang, Mingzhu ; Shen, Yu ; Gao, Awei ; Tian, Xiaohe ; Zhang, Qiong ; Wu, Jieying ; Tian, Yupeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c307t-350d7d267657e2570f3b140ffa2999a20b7f3ee556df7e532b010980a20394083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biocompatibility</topic><topic>Charge transfer</topic><topic>Crystallography</topic><topic>Fatty liver</topic><topic>Fluorescence</topic><topic>Health hazards</topic><topic>In vivo methods and tests</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>Photon absorption</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shao, Tao</creatorcontrib><creatorcontrib>Liu, Tianyan</creatorcontrib><creatorcontrib>Liu, Hui</creatorcontrib><creatorcontrib>Zhang, Mingzhu</creatorcontrib><creatorcontrib>Shen, Yu</creatorcontrib><creatorcontrib>Gao, Awei</creatorcontrib><creatorcontrib>Tian, Xiaohe</creatorcontrib><creatorcontrib>Zhang, Qiong</creatorcontrib><creatorcontrib>Wu, Jieying</creatorcontrib><creatorcontrib>Tian, Yupeng</creatorcontrib><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shao, Tao</au><au>Liu, Tianyan</au><au>Liu, Hui</au><au>Zhang, Mingzhu</au><au>Shen, Yu</au><au>Gao, Awei</au><au>Tian, Xiaohe</au><au>Zhang, Qiong</au><au>Wu, Jieying</au><au>Tian, Yupeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><date>2019-06-12</date><risdate>2019</risdate><volume>7</volume><issue>23</issue><spage>374</spage><epage>379</epage><pages>374-379</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Fatty liver disease (FLD) is one of the major hazards to human health, but effectively and accurately detecting it during its various phases remains challenging. To address this issue, in the current work, four BODIPY analogues (
01B-04B
) with different donor/acceptor groups were rationally designed. Photophysical and theoretical studies demonstrated an obvious intramolecular charge transfer (ICT) in
03B
, with two-photon action cross-sections up to 198 GM in the near-infrared region. An initial
in vitro
assessment indicated that
03B
could interact with the lipid substances with a significant fluorescence enhancement. Due to its high biocompatibility, lipid affinity, and sensitivity,
03B
could target model 3T3-L1 cells at various FLD-induced stages. Furthermore, an
in vivo
study demonstrated the ability to use
03B
to clearly distinguish FLD tissue and display a lesion
in situ
. These results offered a promising optical tool for evaluating FLD at various phases and monitoring its dynamics at the sub-cellular level.
03B
can target 3T3-L1 model cells at different fatty liver disease (FLD)-induced stages and clearly distinguish FLD tissue and display a lesion
in situ
.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><doi>10.1039/c9tb00421a</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9023-2555</orcidid><orcidid>https://orcid.org/0000-0001-7603-546X</orcidid><orcidid>https://orcid.org/0000-0002-5360-3951</orcidid><orcidid>https://orcid.org/0000-0002-2294-3945</orcidid><orcidid>https://orcid.org/0000-0003-2811-2066</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2050-750X |
| ispartof | Journal of materials chemistry. B, Materials for biology and medicine, 2019-06, Vol.7 (23), p.374-379 |
| issn | 2050-750X 2050-7518 |
| language | eng |
| recordid | cdi_proquest_journals_2238867064 |
| source | Royal Society Of Chemistry Journals |
| subjects | Biocompatibility Charge transfer Crystallography Fatty liver Fluorescence Health hazards In vivo methods and tests Lipids Liver Liver diseases Photon absorption |
| title | Identification of fatty liver disease at diverse stages using two-photon absorption of triphenylamine-based BODIPY analogues |
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