Square Wave Stripping Voltammetric Determination of Pantoprazole in Rabbit Plasma using Surfactant-based Pencil Graphite Electrode

Simple, inexpensive, accurate and sensitive square wave adsorptive stripping voltammetry method depends on oxidation of anti-ulcer drug pantoprazole sodium on pencil graphite electrode using sodium dodecyl sulphate as a surfactant at pH 6.0 was introduced. The current signal due to the oxidation pro...

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Veröffentlicht in:Journal of analytical chemistry (New York, N.Y.) N.Y.), 2019-06, Vol.74 (6), p.609-616
Hauptverfasser: Pakinaz Y. Khashaba, Ali, Hassan Refat H., El-Wekil, Mohamed M.
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Ali, Hassan Refat H.
El-Wekil, Mohamed M.
description Simple, inexpensive, accurate and sensitive square wave adsorptive stripping voltammetry method depends on oxidation of anti-ulcer drug pantoprazole sodium on pencil graphite electrode using sodium dodecyl sulphate as a surfactant at pH 6.0 was introduced. The current signal due to the oxidation process as a function of the amount of the cited drug, pH of the medium, type of surfactant, frequency and adsorption time at the electrode surface was studied. The oxidation peak current varied linearly with the concentration over the range of 5 × 10 –9 –6 × 10 –6 M. The limit of detection was 2 nM. The validity of the proposed method for pharmacokinetic study in rabbit plasma was conducted.
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subjects Adsorptivity
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Electrodes
Graphite
Oxidation
Pharmacology
Signal processing
Sodium dodecyl sulfate
Square waves
Stripping
Surfactants
Voltammetry
title Square Wave Stripping Voltammetric Determination of Pantoprazole in Rabbit Plasma using Surfactant-based Pencil Graphite Electrode
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