Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial

The efficacy of programmed cell death protein 1 (PD-1) blockade in metastatic triple-negative breast cancer (TNBC) is low 1 – 5 , highlighting a need for strategies that render the tumor microenvironment more sensitive to PD-1 blockade. Preclinical research has suggested immunomodulatory propertie...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2019-06, Vol.25 (6), p.920-928
Hauptverfasser:	Voorwerk, Leonie, Slagter, Maarten, Horlings, Hugo M., Sikorska, Karolina, van de Vijver, Koen K., de Maaker, Michiel, Nederlof, Iris, Kluin, Roelof J. C., Warren, Sarah, Ong, SuFey, Wiersma, Terry G., Russell, Nicola S., Lalezari, Ferry, Schouten, Philip C., Bakker, Noor A. M., Ketelaars, Steven L. C., Peters, Dennis, Lange, Charlotte A. H., van Werkhoven, Erik, van Tinteren, Harm, Mandjes, Ingrid A. M., Kemper, Inge, Onderwater, Suzanne, Chalabi, Myriam, Wilgenhof, Sofie, Haanen, John B. A. G., Salgado, Roberto, de Visser, Karin E., Sonke, Gabe S., Wessels, Lodewyk F. A., Linn, Sabine C., Schumacher, Ton N., Blank, Christian U., Kok, Marleen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/251 631/67/1347 692/308/2779/109/2425 692/308/53 692/308/575 Adult Aged Antimitotic agents Antineoplastic agents Antineoplastic Agents, Immunological - administration & dosage Apoptosis B7-H1 Antigen - antagonists & inhibitors Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cell death Chemotherapy Cisplatin Cisplatin - administration & dosage Combined Modality Therapy Cyclophosphamide Cyclophosphamide - administration & dosage Cytotoxicity Doxorubicin Doxorubicin - administration & dosage Female Genes Humans Immunomodulation Immunotherapy Infectious Diseases Irradiation Letter Lymphocytes Lymphocytes T Metabolic Diseases Metastases Metastasis Methods Middle Aged Molecular Medicine Monoclonal antibodies Neoplasm Metastasis - genetics Neoplasm Metastasis - immunology Neoplasm Metastasis - therapy Neurosciences Nivolumab - administration & dosage PD-1 protein PD-L1 protein Programmed Cell Death 1 Receptor - antagonists & inhibitors Radiotherapy, Adjuvant Sensitivity enhancement T-Lymphocytes, Cytotoxic - drug effects T-Lymphocytes, Cytotoxic - immunology Targeted cancer therapy Testing Toxicity Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - immunology Triple Negative Breast Neoplasms - therapy Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Tumor Microenvironment - immunology Tumor necrosis factor-α Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!