Morphine Suppresses the Oxytocin Response in Breast-Feeding Women
The activity of opiate-mediated regulatory mechanisms of oxytocin secretion during breast-feeding was studied by the administration of either morphine, naloxone or placebo to women prior to the commencement of breast-feeding. Seventeen healthy women in the first week after delivery who had establish...
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| Veröffentlicht in: | Gynecologic and obstetric investigation 1999-01, Vol.48 (1), p.33-37 |
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| container_title | Gynecologic and obstetric investigation |
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| creator | Lindow, S.W. Hendricks, M.S. Nugent, F.A. Dunne, T.T. van der Spuy, Z.M. |
| description | The activity of opiate-mediated regulatory mechanisms of oxytocin secretion during breast-feeding was studied by the administration of either morphine, naloxone or placebo to women prior to the commencement of breast-feeding. Seventeen healthy women in the first week after delivery who had established lactation were ramdomized to receive either intravenous morphine 5 mg (n = 6), naloxone 2.4 mg (n = 6) or a placebo, sterile water (n = 5), which was given prior to commencement of breast-feeding. Oxytocin levels were measured by radioimmunoassay prior to initiation of breast-feeding and then at 2-min intervals until the feed was complete. Breast-feeding produced a significant rise in oxytocin levels in the control and naloxone groups but no significant rise in the patients given morphine. There was a significant reduction in oxytocin response following morphine administration when compared to placebo but not between naloxone and placebo. In conclusion, oxytocin secretion to breast-feeding is inhibited by exogenous morphine when compared to a control group but the administration of naloxone did not produce a significant difference from control. |
| doi_str_mv | 10.1159/000010130 |
| format | Article |
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Seventeen healthy women in the first week after delivery who had established lactation were ramdomized to receive either intravenous morphine 5 mg (n = 6), naloxone 2.4 mg (n = 6) or a placebo, sterile water (n = 5), which was given prior to commencement of breast-feeding. Oxytocin levels were measured by radioimmunoassay prior to initiation of breast-feeding and then at 2-min intervals until the feed was complete. Breast-feeding produced a significant rise in oxytocin levels in the control and naloxone groups but no significant rise in the patients given morphine. There was a significant reduction in oxytocin response following morphine administration when compared to placebo but not between naloxone and placebo. In conclusion, oxytocin secretion to breast-feeding is inhibited by exogenous morphine when compared to a control group but the administration of naloxone did not produce a significant difference from control.</description><identifier>ISSN: 0378-7346</identifier><identifier>EISSN: 1423-002X</identifier><identifier>DOI: 10.1159/000010130</identifier><identifier>PMID: 10394089</identifier><identifier>CODEN: GOBIDS</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult ; Biological and medical sciences ; Breast Feeding ; Female ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Humans ; Lactation - drug effects ; Lactation - physiology ; Morphine - pharmacology ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Narcotics - pharmacology ; Original Paper ; Oxytocin - blood ; Oxytocin - secretion ; Placebos ; Pregnancy. Parturition. Lactation ; Tropical medicine ; Vertebrates: reproduction</subject><ispartof>Gynecologic and obstetric investigation, 1999-01, Vol.48 (1), p.33-37</ispartof><rights>1999 S. Karger AG, Basel</rights><rights>1999 INIST-CNRS</rights><rights>Copyright (c) 1999 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-e6da83ce8ce8b790cf60f7080c3ef953065faf6e13c1c193d4a5ad7071ae2df3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2427,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1847444$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10394089$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindow, S.W.</creatorcontrib><creatorcontrib>Hendricks, M.S.</creatorcontrib><creatorcontrib>Nugent, F.A.</creatorcontrib><creatorcontrib>Dunne, T.T.</creatorcontrib><creatorcontrib>van der Spuy, Z.M.</creatorcontrib><title>Morphine Suppresses the Oxytocin Response in Breast-Feeding Women</title><title>Gynecologic and obstetric investigation</title><addtitle>Gynecol Obstet Invest</addtitle><description>The activity of opiate-mediated regulatory mechanisms of oxytocin secretion during breast-feeding was studied by the administration of either morphine, naloxone or placebo to women prior to the commencement of breast-feeding. Seventeen healthy women in the first week after delivery who had established lactation were ramdomized to receive either intravenous morphine 5 mg (n = 6), naloxone 2.4 mg (n = 6) or a placebo, sterile water (n = 5), which was given prior to commencement of breast-feeding. Oxytocin levels were measured by radioimmunoassay prior to initiation of breast-feeding and then at 2-min intervals until the feed was complete. Breast-feeding produced a significant rise in oxytocin levels in the control and naloxone groups but no significant rise in the patients given morphine. There was a significant reduction in oxytocin response following morphine administration when compared to placebo but not between naloxone and placebo. In conclusion, oxytocin secretion to breast-feeding is inhibited by exogenous morphine when compared to a control group but the administration of naloxone did not produce a significant difference from control.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Breast Feeding</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Humans</subject><subject>Lactation - drug effects</subject><subject>Lactation - physiology</subject><subject>Morphine - pharmacology</subject><subject>Naloxone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Narcotics - pharmacology</subject><subject>Original Paper</subject><subject>Oxytocin - blood</subject><subject>Oxytocin - secretion</subject><subject>Placebos</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Tropical medicine</subject><subject>Vertebrates: reproduction</subject><issn>0378-7346</issn><issn>1423-002X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0EtLxDAUBeAgio6PhWtBiojgonrTpHksR_EFyoAKuisxvdHqTFuTFvTfG-2gIoZAAvk4NxxCNikcUJrrQ4iLAmWwQEaUZywFyO4XyQiYVKlkXKyQ1RCeI8q14stkhQLTHJQekfFV49unqsbkpm9bjyFgSLonTCZv711jqzq5xtA2dcAk3o88mtClp4hlVT8md80M63Wy5Mw04Mb8XCO3pye3x-fp5eTs4nh8mVqmeJeiKI1iFlXcD1KDdQKcBAWWodM5A5E74wRSZqmlmpXc5KaUIKnBrHRsjewNsa1vXnsMXTGrgsXp1NTY9KEQWslMCRHhzh_43PS-jl8rsoxJCVqoiPYHZH0TgkdXtL6aGf9eUCg-Oy2-O412ex7YP8yw_CWHEiPYnQMTrJk6b2pbhR-nuOScR7Y1sBfjH9H_yhmm7Pz7eja5-AJFG0v4AFE6kWA</recordid><startdate>19990101</startdate><enddate>19990101</enddate><creator>Lindow, S.W.</creator><creator>Hendricks, M.S.</creator><creator>Nugent, F.A.</creator><creator>Dunne, T.T.</creator><creator>van der Spuy, Z.M.</creator><general>Karger</general><general>S. 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Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Humans</topic><topic>Lactation - drug effects</topic><topic>Lactation - physiology</topic><topic>Morphine - pharmacology</topic><topic>Naloxone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Narcotics - pharmacology</topic><topic>Original Paper</topic><topic>Oxytocin - blood</topic><topic>Oxytocin - secretion</topic><topic>Placebos</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Tropical medicine</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindow, S.W.</creatorcontrib><creatorcontrib>Hendricks, M.S.</creatorcontrib><creatorcontrib>Nugent, F.A.</creatorcontrib><creatorcontrib>Dunne, T.T.</creatorcontrib><creatorcontrib>van der Spuy, Z.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic and obstetric investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindow, S.W.</au><au>Hendricks, M.S.</au><au>Nugent, F.A.</au><au>Dunne, T.T.</au><au>van der Spuy, Z.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Morphine Suppresses the Oxytocin Response in Breast-Feeding Women</atitle><jtitle>Gynecologic and obstetric investigation</jtitle><addtitle>Gynecol Obstet Invest</addtitle><date>1999-01-01</date><risdate>1999</risdate><volume>48</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>0378-7346</issn><eissn>1423-002X</eissn><coden>GOBIDS</coden><abstract>The activity of opiate-mediated regulatory mechanisms of oxytocin secretion during breast-feeding was studied by the administration of either morphine, naloxone or placebo to women prior to the commencement of breast-feeding. Seventeen healthy women in the first week after delivery who had established lactation were ramdomized to receive either intravenous morphine 5 mg (n = 6), naloxone 2.4 mg (n = 6) or a placebo, sterile water (n = 5), which was given prior to commencement of breast-feeding. Oxytocin levels were measured by radioimmunoassay prior to initiation of breast-feeding and then at 2-min intervals until the feed was complete. Breast-feeding produced a significant rise in oxytocin levels in the control and naloxone groups but no significant rise in the patients given morphine. There was a significant reduction in oxytocin response following morphine administration when compared to placebo but not between naloxone and placebo. In conclusion, oxytocin secretion to breast-feeding is inhibited by exogenous morphine when compared to a control group but the administration of naloxone did not produce a significant difference from control.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>10394089</pmid><doi>10.1159/000010130</doi><tpages>5</tpages></addata></record> |
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| ispartof | Gynecologic and obstetric investigation, 1999-01, Vol.48 (1), p.33-37 |
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| source | MEDLINE; Karger Journals |
| subjects | Adult Biological and medical sciences Breast Feeding Female Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Humans Lactation - drug effects Lactation - physiology Morphine - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Original Paper Oxytocin - blood Oxytocin - secretion Placebos Pregnancy. Parturition. Lactation Tropical medicine Vertebrates: reproduction |
| title | Morphine Suppresses the Oxytocin Response in Breast-Feeding Women |
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