EMERGING PRINCIPLES OF CONFORMATION-BASED PRION INHERITANCE

The prion hypothesis proposes that proteins can act as infectious agents. Originally formulated to explain transmissible spongiform encephalopathies (TSEs), the prion hypothesis has been extended with the finding that several non-Mendelian traits in fungi are due to heritable changes in protein conf...

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Veröffentlicht in:	Annual review of biochemistry 2004-01, Vol.73 (1), p.617-656
Hauptverfasser:	Chien, Peter, Weissman, Jonathan S, DePace, Angela H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates amyloid Amyloid - chemistry Animals Cells Fungal Proteins - chemistry Humans Infections Macromolecular Substances Mammals Microscopy, Electron misfolding Models, Biological Models, Molecular Mutation Physical properties Polymorphism, Genetic Prion Diseases - etiology Prion Diseases - transmission prion strains Prions Prions - chemistry Prions - genetics Prions - pathogenicity Prions - ultrastructure Protein Conformation Protein Folding Proteins PSI Solubility species barrier Species Specificity Yeast Yeasts
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