Clinical Presentation, Diagnosis and Survival of Resected Distal Bile Duct Cancer
The aim of the study was the definition of the clinical features and survival of 27 resected cases of distal bile duct carcinoma. This neoplasm accounted for 14% of all periampullary malignancies treated by pancreaticoduodenectomy between 1990 and 1996. Jaundice was present in 96% of patients, but w...
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| Veröffentlicht in: | Digestive surgery 1998-01, Vol.15 (5), p.410-416 |
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| creator | Zerbi, Alessandro Balzano, Gianpaolo Leone, Biagio E. Angeli, Enzo Veronesi, Paolo Di Carlo, Valerio |
| description | The aim of the study was the definition of the clinical features and survival of 27 resected cases of distal bile duct carcinoma. This neoplasm accounted for 14% of all periampullary malignancies treated by pancreaticoduodenectomy between 1990 and 1996. Jaundice was present in 96% of patients, but was the first symptom only in 78%. Preoperative investigations allowed to recognize distal bile duct cancer in a minority of patients (41%). Operative mortality and morbidity were 3.7 and 44%, respectively. Most patients (88%) were assigned to UICC stage IV-A. Postoperative survival was not significantly better than survival of 101 patients undergoing pancreaticoduodenectomy for pancreatic ductal carcinoma; median survival was 22 months, with a 13% 5-year survival rate. Determinants of a better prognosis were UICC stage |
| doi_str_mv | 10.1159/000018654 |
| format | Article |
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This neoplasm accounted for 14% of all periampullary malignancies treated by pancreaticoduodenectomy between 1990 and 1996. Jaundice was present in 96% of patients, but was the first symptom only in 78%. Preoperative investigations allowed to recognize distal bile duct cancer in a minority of patients (41%). Operative mortality and morbidity were 3.7 and 44%, respectively. Most patients (88%) were assigned to UICC stage IV-A. Postoperative survival was not significantly better than survival of 101 patients undergoing pancreaticoduodenectomy for pancreatic ductal carcinoma; median survival was 22 months, with a 13% 5-year survival rate. Determinants of a better prognosis were UICC stage <IV-A (p = 0.05) and absence of lymphatic invasion (p < 0.01); prognostic significance of nodal involvement, tumor grading, perineural invasion, tumor size, pylorus preservation and adjuvant therapies could not be proven. Lymphatic invasion was the strongest determinant of survival on multivariate analysis (p < 0.01).</description><identifier>ISSN: 0253-4886</identifier><identifier>EISSN: 1421-9883</identifier><identifier>DOI: 10.1159/000018654</identifier><identifier>PMID: 9845623</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - mortality ; Adenocarcinoma - surgery ; Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms - diagnosis ; Bile Duct Neoplasms - mortality ; Bile Duct Neoplasms - surgery ; Cholangiopancreatography, Endoscopic Retrograde ; Diagnosis, Differential ; Female ; Follow-Up Studies ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Original Paper ; Pancreaticoduodenectomy - mortality ; Prognosis ; Retrospective Studies ; Survival Rate ; Tomography, X-Ray Computed</subject><ispartof>Digestive surgery, 1998-01, Vol.15 (5), p.410-416</ispartof><rights>1998 S. Karger AG, Basel</rights><rights>Copyright (c) 1998 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-c01585ebbf94a61bf8abbca1c225f2d8f35be92f3b0f01112fdffb17f12dbd4d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9845623$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zerbi, Alessandro</creatorcontrib><creatorcontrib>Balzano, Gianpaolo</creatorcontrib><creatorcontrib>Leone, Biagio E.</creatorcontrib><creatorcontrib>Angeli, Enzo</creatorcontrib><creatorcontrib>Veronesi, Paolo</creatorcontrib><creatorcontrib>Di Carlo, Valerio</creatorcontrib><title>Clinical Presentation, Diagnosis and Survival of Resected Distal Bile Duct Cancer</title><title>Digestive surgery</title><addtitle>Dig Surg</addtitle><description>The aim of the study was the definition of the clinical features and survival of 27 resected cases of distal bile duct carcinoma. This neoplasm accounted for 14% of all periampullary malignancies treated by pancreaticoduodenectomy between 1990 and 1996. Jaundice was present in 96% of patients, but was the first symptom only in 78%. Preoperative investigations allowed to recognize distal bile duct cancer in a minority of patients (41%). Operative mortality and morbidity were 3.7 and 44%, respectively. Most patients (88%) were assigned to UICC stage IV-A. Postoperative survival was not significantly better than survival of 101 patients undergoing pancreaticoduodenectomy for pancreatic ductal carcinoma; median survival was 22 months, with a 13% 5-year survival rate. Determinants of a better prognosis were UICC stage <IV-A (p = 0.05) and absence of lymphatic invasion (p < 0.01); prognostic significance of nodal involvement, tumor grading, perineural invasion, tumor size, pylorus preservation and adjuvant therapies could not be proven. Lymphatic invasion was the strongest determinant of survival on multivariate analysis (p < 0.01).</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bile Duct Neoplasms - diagnosis</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Cholangiopancreatography, Endoscopic Retrograde</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original Paper</subject><subject>Pancreaticoduodenectomy - mortality</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tomography, X-Ray Computed</subject><issn>0253-4886</issn><issn>1421-9883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0NtLwzAUBvAgypzTB59FKHsQBKs5SVPTR928wcDL3HPJVaJdO5N24H9vdENBzEsg3y8fh4PQPuBTAFac4XiA5yzbQH3ICKQF53QT9TFhNM04z7fRTgivUdG8gB7qFTxjOaF99DiqXO2UqJIHb4KpW9G6pj5Jxk681E1wIRG1TqadX7plRI1NniJTrdGRhDY-XbrKJONOtclI1Mr4XbRlRRXM3voeoNn11fPoNp3c39yNLiapoixrU4WBcWaktEUmcpCWCymVAEUIs0RzS5k0BbFUYosBgFhtrYRzC0RLnWk6QEer3oVv3jsT2nLugjJVJWrTdKE8x4AZpjzC4R_42nS-jrOVhNA8VrMiouMVUr4JwRtbLrybC_9RAi6_dlz-7Djaw3VhJ-dG_8j1UmN-sMrfhH8x_rdp_Xv4bzqezr5BudCWfgLsXIqB</recordid><startdate>19980101</startdate><enddate>19980101</enddate><creator>Zerbi, Alessandro</creator><creator>Balzano, Gianpaolo</creator><creator>Leone, Biagio E.</creator><creator>Angeli, Enzo</creator><creator>Veronesi, Paolo</creator><creator>Di Carlo, Valerio</creator><general>S. 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Academic</collection><jtitle>Digestive surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zerbi, Alessandro</au><au>Balzano, Gianpaolo</au><au>Leone, Biagio E.</au><au>Angeli, Enzo</au><au>Veronesi, Paolo</au><au>Di Carlo, Valerio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Presentation, Diagnosis and Survival of Resected Distal Bile Duct Cancer</atitle><jtitle>Digestive surgery</jtitle><addtitle>Dig Surg</addtitle><date>1998-01-01</date><risdate>1998</risdate><volume>15</volume><issue>5</issue><spage>410</spage><epage>416</epage><pages>410-416</pages><issn>0253-4886</issn><eissn>1421-9883</eissn><abstract>The aim of the study was the definition of the clinical features and survival of 27 resected cases of distal bile duct carcinoma. This neoplasm accounted for 14% of all periampullary malignancies treated by pancreaticoduodenectomy between 1990 and 1996. Jaundice was present in 96% of patients, but was the first symptom only in 78%. Preoperative investigations allowed to recognize distal bile duct cancer in a minority of patients (41%). Operative mortality and morbidity were 3.7 and 44%, respectively. Most patients (88%) were assigned to UICC stage IV-A. Postoperative survival was not significantly better than survival of 101 patients undergoing pancreaticoduodenectomy for pancreatic ductal carcinoma; median survival was 22 months, with a 13% 5-year survival rate. Determinants of a better prognosis were UICC stage <IV-A (p = 0.05) and absence of lymphatic invasion (p < 0.01); prognostic significance of nodal involvement, tumor grading, perineural invasion, tumor size, pylorus preservation and adjuvant therapies could not be proven. Lymphatic invasion was the strongest determinant of survival on multivariate analysis (p < 0.01).</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>9845623</pmid><doi>10.1159/000018654</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - mortality Adenocarcinoma - surgery Adult Aged Aged, 80 and over Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - mortality Bile Duct Neoplasms - surgery Cholangiopancreatography, Endoscopic Retrograde Diagnosis, Differential Female Follow-Up Studies Humans Lymphatic Metastasis Male Middle Aged Original Paper Pancreaticoduodenectomy - mortality Prognosis Retrospective Studies Survival Rate Tomography, X-Ray Computed |
| title | Clinical Presentation, Diagnosis and Survival of Resected Distal Bile Duct Cancer |
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