Pitavastatin attenuates cisplatin‐induced renal injury by targeting MAPK and apoptotic pathways

Objective Anti‐neoplastic drug cisplatin is prescribed widely for treatment of a variety of malignancies. Its use has been restricted lately due to severe renal toxicity. The purpose of current study was to investigate the effect of pitavastatin (a hypolipidaemic drug) in cisplatin‐induced acute kid...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2019-07, Vol.71 (7), p.1072-1081
Hauptverfasser:	Kaushik, Swati, Tomar, Ameesha, Puthanmadhom Narayanan, Susrutha, Nag, Tapas Chandra, Arya, Dharamvir Singh, Bhatia, Jagriti
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - metabolism Acute Kidney Injury - pathology Animals Antineoplastic Agents - adverse effects Apoptosis Apoptosis - drug effects Chemotherapy Cisplatin Cisplatin - adverse effects DNA fragmentation Immunohistochemistry Kidney - metabolism Kidney - pathology Kidney - ultrastructure Kidneys Male MAP kinase MAP Kinase Signaling System - drug effects MAPK Molecular modelling nephrotoxicity pitavastatin Quinolines - pharmacology Rats Rats, Wistar Rodents Toxicity
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