Tuning the In Vivo Transport of Anticancer Drugs Using Renal‐Clearable Gold Nanoparticles
Precise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting‐clearance and permeat...
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Veröffentlicht in: | Angewandte Chemie International Edition 2019-06, Vol.58 (25), p.8479-8483 |
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creator | Peng, Chuanqi Xu, Jing Yu, Mengxiao Ning, Xuhui Huang, Yingyu Du, Bujie Hernandez, Elizabeth Kapur, Payal Hsieh, Jer‐Tsong Zheng, Jie |
description | Precise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting‐clearance and permeation‐retention paradoxes in the anticancer‐drug delivery. Herein, we systematically investigated how renal‐clearable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticancer drug doxorubicin in both cancerous and normal tissues. Renal‐clearable AuNPs retain the advantages of the free drug, including rapid tumor targeting and high tumor vascular permeability. The renal‐clearable AuNPs also accelerated body clearance of off‐target drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long‐standing paradoxes in the anticancer drug delivery.
The best of both worlds: Long‐standing paradoxes in anticancer drug delivery, including high tumor targeting vs. rapid clearance, and high permeability vs. low systemic toxicity, can be addressed by using renal‐clearable gold nanoparticles (AuNPs). Doxorubicin‐loaded AuNPs (DOX@AuNPs) retain the rapid tumor targeting and high tumor permeability of the free drug, and off‐target DOX@AuNPs are more quickly cleared from the body than the free drug. |
doi_str_mv | 10.1002/anie.201903256 |
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The best of both worlds: Long‐standing paradoxes in anticancer drug delivery, including high tumor targeting vs. rapid clearance, and high permeability vs. low systemic toxicity, can be addressed by using renal‐clearable gold nanoparticles (AuNPs). Doxorubicin‐loaded AuNPs (DOX@AuNPs) retain the rapid tumor targeting and high tumor permeability of the free drug, and off‐target DOX@AuNPs are more quickly cleared from the body than the free drug.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201903256</identifier><identifier>PMID: 31006932</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Antineoplastic drugs ; Antitumor agents ; Cancer ; Doxorubicin ; Drug delivery ; Drug delivery systems ; Drugs ; enhanced permeability and retention effect ; Gold ; gold nanoparticles ; Kidneys ; Nanoparticles ; Paradoxes ; Penetration ; Permeability ; renal clearance ; Retention ; Transport ; tumor targeting ; Tumors</subject><ispartof>Angewandte Chemie International Edition, 2019-06, Vol.58 (25), p.8479-8483</ispartof><rights>2019 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3656-68a44927040d8c45201bca8adeea8ede7dafa429ebcd7f3e7992bd467e6356f33</citedby><cites>FETCH-LOGICAL-c3656-68a44927040d8c45201bca8adeea8ede7dafa429ebcd7f3e7992bd467e6356f33</cites><orcidid>0000-0001-8546-1882</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201903256$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201903256$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31006932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peng, Chuanqi</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Yu, Mengxiao</creatorcontrib><creatorcontrib>Ning, Xuhui</creatorcontrib><creatorcontrib>Huang, Yingyu</creatorcontrib><creatorcontrib>Du, Bujie</creatorcontrib><creatorcontrib>Hernandez, Elizabeth</creatorcontrib><creatorcontrib>Kapur, Payal</creatorcontrib><creatorcontrib>Hsieh, Jer‐Tsong</creatorcontrib><creatorcontrib>Zheng, Jie</creatorcontrib><title>Tuning the In Vivo Transport of Anticancer Drugs Using Renal‐Clearable Gold Nanoparticles</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Precise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting‐clearance and permeation‐retention paradoxes in the anticancer‐drug delivery. Herein, we systematically investigated how renal‐clearable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticancer drug doxorubicin in both cancerous and normal tissues. Renal‐clearable AuNPs retain the advantages of the free drug, including rapid tumor targeting and high tumor vascular permeability. The renal‐clearable AuNPs also accelerated body clearance of off‐target drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long‐standing paradoxes in the anticancer drug delivery.
The best of both worlds: Long‐standing paradoxes in anticancer drug delivery, including high tumor targeting vs. rapid clearance, and high permeability vs. low systemic toxicity, can be addressed by using renal‐clearable gold nanoparticles (AuNPs). Doxorubicin‐loaded AuNPs (DOX@AuNPs) retain the rapid tumor targeting and high tumor permeability of the free drug, and off‐target DOX@AuNPs are more quickly cleared from the body than the free drug.</description><subject>Antineoplastic drugs</subject><subject>Antitumor agents</subject><subject>Cancer</subject><subject>Doxorubicin</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>enhanced permeability and retention effect</subject><subject>Gold</subject><subject>gold nanoparticles</subject><subject>Kidneys</subject><subject>Nanoparticles</subject><subject>Paradoxes</subject><subject>Penetration</subject><subject>Permeability</subject><subject>renal clearance</subject><subject>Retention</subject><subject>Transport</subject><subject>tumor targeting</subject><subject>Tumors</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkLFOwzAQhi0EoqWwMiJLzCmOndjOWJVSKlVFQi0bipzkUlKlTrATULcu7Dxjn4RELWVkuhu-79fdj9C1S_ouIfRO6Qz6lLgBYdTnJ6jr-tR1mBDstNk9xhwhfbeDLqxdNbyUhJ-jDmtcHjDaRa_zWmd6ias3wBO92369ZB8FnhulbVmYChcpHugqi5WOweB7Uy8tXtjWeAat8t32e5iDMirKAY-LPMEzpYtSmUbJwV6is1TlFq4Os4cWD6P58NGZPo0nw8HUiRn3ucOl8ryACuKRRMae3_wTxUqqBEBJSEAkKlUeDSCKE5EyEEFAo8TjAjjzecpYD93uc0tTvNdgq3BV1Ka5z4aUMk6Ey2VL9fdUbAprDaRhabK1MpvQJWHbZti2GR7bbISbQ2wdrSE54r_1NUCwBz6zHDb_xIWD2WT0F_4Dv3ODRw</recordid><startdate>20190617</startdate><enddate>20190617</enddate><creator>Peng, Chuanqi</creator><creator>Xu, Jing</creator><creator>Yu, Mengxiao</creator><creator>Ning, Xuhui</creator><creator>Huang, Yingyu</creator><creator>Du, Bujie</creator><creator>Hernandez, Elizabeth</creator><creator>Kapur, Payal</creator><creator>Hsieh, Jer‐Tsong</creator><creator>Zheng, Jie</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0001-8546-1882</orcidid></search><sort><creationdate>20190617</creationdate><title>Tuning the In Vivo Transport of Anticancer Drugs Using Renal‐Clearable Gold Nanoparticles</title><author>Peng, Chuanqi ; Xu, Jing ; Yu, Mengxiao ; Ning, Xuhui ; Huang, Yingyu ; Du, Bujie ; Hernandez, Elizabeth ; Kapur, Payal ; Hsieh, Jer‐Tsong ; Zheng, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3656-68a44927040d8c45201bca8adeea8ede7dafa429ebcd7f3e7992bd467e6356f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Antineoplastic drugs</topic><topic>Antitumor agents</topic><topic>Cancer</topic><topic>Doxorubicin</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>enhanced permeability and retention effect</topic><topic>Gold</topic><topic>gold nanoparticles</topic><topic>Kidneys</topic><topic>Nanoparticles</topic><topic>Paradoxes</topic><topic>Penetration</topic><topic>Permeability</topic><topic>renal clearance</topic><topic>Retention</topic><topic>Transport</topic><topic>tumor targeting</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Chuanqi</creatorcontrib><creatorcontrib>Xu, Jing</creatorcontrib><creatorcontrib>Yu, Mengxiao</creatorcontrib><creatorcontrib>Ning, Xuhui</creatorcontrib><creatorcontrib>Huang, Yingyu</creatorcontrib><creatorcontrib>Du, Bujie</creatorcontrib><creatorcontrib>Hernandez, Elizabeth</creatorcontrib><creatorcontrib>Kapur, Payal</creatorcontrib><creatorcontrib>Hsieh, Jer‐Tsong</creatorcontrib><creatorcontrib>Zheng, Jie</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Chuanqi</au><au>Xu, Jing</au><au>Yu, Mengxiao</au><au>Ning, Xuhui</au><au>Huang, Yingyu</au><au>Du, Bujie</au><au>Hernandez, Elizabeth</au><au>Kapur, Payal</au><au>Hsieh, Jer‐Tsong</au><au>Zheng, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuning the In Vivo Transport of Anticancer Drugs Using Renal‐Clearable Gold Nanoparticles</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2019-06-17</date><risdate>2019</risdate><volume>58</volume><issue>25</issue><spage>8479</spage><epage>8483</epage><pages>8479-8483</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Precise control of in vivo transport of anticancer drugs in normal and cancerous tissues with engineered nanoparticles is key to the future success of cancer nanomedicines in clinics. This requires a fundamental understanding of how engineered nanoparticles impact the targeting‐clearance and permeation‐retention paradoxes in the anticancer‐drug delivery. Herein, we systematically investigated how renal‐clearable gold nanoparticles (AuNPs) affect the permeation, distribution, and retention of the anticancer drug doxorubicin in both cancerous and normal tissues. Renal‐clearable AuNPs retain the advantages of the free drug, including rapid tumor targeting and high tumor vascular permeability. The renal‐clearable AuNPs also accelerated body clearance of off‐target drug via renal elimination. These results clearly indicate that diverse in vivo transport behaviors of engineered nanoparticles can be used to reconcile long‐standing paradoxes in the anticancer drug delivery.
The best of both worlds: Long‐standing paradoxes in anticancer drug delivery, including high tumor targeting vs. rapid clearance, and high permeability vs. low systemic toxicity, can be addressed by using renal‐clearable gold nanoparticles (AuNPs). Doxorubicin‐loaded AuNPs (DOX@AuNPs) retain the rapid tumor targeting and high tumor permeability of the free drug, and off‐target DOX@AuNPs are more quickly cleared from the body than the free drug.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31006932</pmid><doi>10.1002/anie.201903256</doi><tpages>5</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0001-8546-1882</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Antineoplastic drugs Antitumor agents Cancer Doxorubicin Drug delivery Drug delivery systems Drugs enhanced permeability and retention effect Gold gold nanoparticles Kidneys Nanoparticles Paradoxes Penetration Permeability renal clearance Retention Transport tumor targeting Tumors |
title | Tuning the In Vivo Transport of Anticancer Drugs Using Renal‐Clearable Gold Nanoparticles |
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