Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy

Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung cancer 1 – 3 . However, this comes at the cost of frequent, serious immune-related adverse events, necessitating a reduction in the recommended do...

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Veröffentlicht in:	Nature (London) 2019-05, Vol.569 (7756), p.428-432
Hauptverfasser:	Perez-Ruiz, Elisabeth, Minute, Luna, Otano, Itziar, Alvarez, Maite, Ochoa, Maria Carmen, Belsue, Virginia, de Andrea, Carlos, Rodriguez-Ruiz, Maria Esperanza, Perez-Gracia, Jose Luis, Marquez-Rodas, Ivan, Llacer, Casilda, Alvarez, Martina, de Luque, Vanesa, Molina, Carmen, Teijeira, Alvaro, Berraondo, Pedro, Melero, Ignacio
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/2 13/21 13/31 13/51 14 38 59 631/250/251 631/67/580 64/60 82/1 Animals Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Anticancer properties Cancer Cancer immunotherapy CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Colitis Colitis - drug therapy Colon Colon cancer Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colorectal cancer Combined modality therapy Complications and side effects CTLA-4 Antigen - antagonists & inhibitors CTLA-4 Antigen - immunology CTLA-4 protein Dextran Sulfate - pharmacology Disease Dosage and administration Drug therapy Effectiveness Female Graft vs Host Disease Graft-versus-host reaction Hepatitis Hepatitis - drug therapy Humanities and Social Sciences Humans Immune checkpoint Immunoglobulins Immunotherapy Immunotherapy - adverse effects Inflammatory bowel disease Intestine Ipilimumab - adverse effects Kidney cancer Letter Leukocytes (mononuclear) Lung cancer Lung carcinoma Lung diseases Lymphocytes Male Melanoma Methods Mice Mice, Inbred C57BL Monoclonal antibodies multidisciplinary Nivolumab - adverse effects Ovarian cancer Patient outcomes PD-1 protein Peripheral blood mononuclear cells Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Prophylaxis RAG2 protein Renal cell carcinoma Science Science (multidisciplinary) Sodium T-Lymphocytes - drug effects T-Lymphocytes - immunology Targeted cancer therapy TNF inhibitors Toxicity Tumor necrosis factor Tumor necrosis factor inhibitors Tumor Necrosis Factor Inhibitors - pharmacology Tumor Necrosis Factor Inhibitors - therapeutic use Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-TNF Tumors Xenograft Model Antitumor Assays Xenografts
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