5-aminolevulinic acid photodynamic therapy reduces HPV viral load via autophagy and apoptosis by modulating Ras/Raf/MEK/ERK and PI3K/AKT pathways in HeLa cells

Human papillomavirus (HPV) infection is linked to several diseases, the most prominent of which are cervical cancer and genital condyloma acuminatum. Previous studies have suggested an effective role for 5-aminolevulinic acid photodynamic therapy (ALA-PDT) against various cancers by the induction of...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2019-05, Vol.194, p.46-55
Hauptverfasser:	Xie, Jiajia, Wang, Sijia, Li, Zhijia, Ao, Chunping, Wang, Jingying, Wang, Li, Peng, Xiaoming, Zeng, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein ALA-PDT Aminolevulinic Acid Apoptosis Apoptosis - drug effects Apoptosis - radiation effects Autophagy Autophagy - drug effects Autophagy - radiation effects Caspase Caspase-3 Cell Death - drug effects Cell Death - radiation effects Cell proliferation Cell Proliferation - drug effects Cell Proliferation - radiation effects Cell Survival - drug effects Cell Survival - radiation effects Cervical cancer Cervix Condyloma acuminatum Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism HeLa HeLa Cells HPV Human papillomavirus Humans Hydroxychloroquine Infections Levulinic Acids - pharmacology MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - radiation effects Papillomaviridae - drug effects Papillomaviridae - physiology Papillomaviridae - radiation effects Phagocytosis Phosphatidylinositol 3-Kinases - metabolism Photochemotherapy Photodynamic therapy Proto-Oncogene Proteins c-akt - metabolism raf Kinases - metabolism ras Proteins - metabolism Reactive oxygen species Reactive Oxygen Species - metabolism TOR protein TOR Serine-Threonine Kinases - metabolism Viral Load - drug effects Viral Load - radiation effects
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