Direct Zinc Finger Protein Persulfidation by H2S Is Facilitated by Zn2

H2S is a gaseous signaling molecule that modifies cysteine residues in proteins to form persulfides (P‐SSH). One family of proteins modified by H2S are zinc finger (ZF) proteins, which contain multiple zinc‐coordinating cysteine residues. Herein, we report the reactivity of H2S with a ZF protein cal...

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Veröffentlicht in:	Angewandte Chemie International Edition 2019-06, Vol.58 (24), p.7997-8001
Hauptverfasser:	Lange, Mike, Ok, Kiwon, Shimberg, Geoffrey D., Bursac, Biljana, Markó, Lajos, Ivanović‐Burmazović, Ivana, Michel, Sarah L. J., Filipovic, Milos R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anisotropy Cysteine Fluorescence Fluorescence spectroscopy Hydrogen sulfide mass spectrometry mRNA Oxidation persulfidation Proteins Residues Superoxide Temperature requirements Tumor necrosis factor-α Zinc Zinc finger proteins
Online-Zugang:	Volltext
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