Chemotherapy‐induced skin toxicity and capillary leak syndrome
Background The occurrence of chemotherapy‐related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS. Methods Leukemia or hematopoietic stem cell transplant patients between January 2...
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| Veröffentlicht in: | International journal of dermatology 2019-07, Vol.58 (7), p.856-860 |
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| container_title | International journal of dermatology |
| container_volume | 58 |
| creator | Hunjan, Manrup K. Nowsheen, Somaira Ramos‐Rodriguez, Alvaro J. Bridges, Alina G. Lehman, Julia S. Hashmi, Shahrukh K. el‐Azhary, Rokea A. |
| description | Background
The occurrence of chemotherapy‐related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.
Methods
Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS.
Results
Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical‐pathologic confirmation.
Conclusions
Although TEC is generally self‐limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy. |
| doi_str_mv | 10.1111/ijd.14392 |
| format | Article |
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The occurrence of chemotherapy‐related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.
Methods
Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS.
Results
Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical‐pathologic confirmation.
Conclusions
Although TEC is generally self‐limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.</description><identifier>ISSN: 0011-9059</identifier><identifier>EISSN: 1365-4632</identifier><identifier>DOI: 10.1111/ijd.14392</identifier><identifier>PMID: 30847892</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Chemotherapy ; Consultation ; Dermatology ; Diagnosis ; Erythema ; Hematopoietic stem cells ; Leukemia ; Medical records ; Patients ; Skin ; Stem cells ; Toxic epidermal necrolysis ; Toxicity</subject><ispartof>International journal of dermatology, 2019-07, Vol.58 (7), p.856-860</ispartof><rights>2019</rights><rights>2019 The International Society of Dermatology.</rights><rights>International Journal of Dermatology © 2019 International Society of Dermatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-14a3c6eb1953bad12ae9949df96f454953ca6a03135edf5982fb5be00298911a3</citedby><cites>FETCH-LOGICAL-c3532-14a3c6eb1953bad12ae9949df96f454953ca6a03135edf5982fb5be00298911a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijd.14392$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijd.14392$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30847892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hunjan, Manrup K.</creatorcontrib><creatorcontrib>Nowsheen, Somaira</creatorcontrib><creatorcontrib>Ramos‐Rodriguez, Alvaro J.</creatorcontrib><creatorcontrib>Bridges, Alina G.</creatorcontrib><creatorcontrib>Lehman, Julia S.</creatorcontrib><creatorcontrib>Hashmi, Shahrukh K.</creatorcontrib><creatorcontrib>el‐Azhary, Rokea A.</creatorcontrib><title>Chemotherapy‐induced skin toxicity and capillary leak syndrome</title><title>International journal of dermatology</title><addtitle>Int J Dermatol</addtitle><description>Background
The occurrence of chemotherapy‐related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.
Methods
Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS.
Results
Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical‐pathologic confirmation.
Conclusions
Although TEC is generally self‐limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.</description><subject>Chemotherapy</subject><subject>Consultation</subject><subject>Dermatology</subject><subject>Diagnosis</subject><subject>Erythema</subject><subject>Hematopoietic stem cells</subject><subject>Leukemia</subject><subject>Medical records</subject><subject>Patients</subject><subject>Skin</subject><subject>Stem cells</subject><subject>Toxic epidermal necrolysis</subject><subject>Toxicity</subject><issn>0011-9059</issn><issn>1365-4632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kEtOwzAQhi0EoqWw4AIoEisWaf0MmR2ovIoqsYG15cSO6jaPYieC7DgCZ-QkGALsmM1oRp_-GX0IHRM8JaFmdq2nhDOgO2hMWCJinjC6i8YYExIDFjBCB96vw8go4ftoxHDKz1OgY3QxX5mqaVfGqW3_8fZua93lRkd-Y-uobV5tbts-UrWOcrW1ZalcH5VGbSLf19o1lTlEe4UqvTn66RP0dHP9OL-Llw-3i_nlMs6ZYDQmXLE8MRkBwTKlCVUGgIMuICm44GGbq0RhRpgwuhCQ0iITmcGYQgqEKDZBp0Pu1jXPnfGtXDedq8NJSSljCYCAJFBnA5W7xntnCrl1tgpPS4LllysZXMlvV4E9-UnsssroP_JXTgBmA_BiS9P_nyQX91dD5Cex6XMu</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Hunjan, Manrup K.</creator><creator>Nowsheen, Somaira</creator><creator>Ramos‐Rodriguez, Alvaro J.</creator><creator>Bridges, Alina G.</creator><creator>Lehman, Julia S.</creator><creator>Hashmi, Shahrukh K.</creator><creator>el‐Azhary, Rokea A.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>201907</creationdate><title>Chemotherapy‐induced skin toxicity and capillary leak syndrome</title><author>Hunjan, Manrup K. ; Nowsheen, Somaira ; Ramos‐Rodriguez, Alvaro J. ; Bridges, Alina G. ; Lehman, Julia S. ; Hashmi, Shahrukh K. ; el‐Azhary, Rokea A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-14a3c6eb1953bad12ae9949df96f454953ca6a03135edf5982fb5be00298911a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Chemotherapy</topic><topic>Consultation</topic><topic>Dermatology</topic><topic>Diagnosis</topic><topic>Erythema</topic><topic>Hematopoietic stem cells</topic><topic>Leukemia</topic><topic>Medical records</topic><topic>Patients</topic><topic>Skin</topic><topic>Stem cells</topic><topic>Toxic epidermal necrolysis</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hunjan, Manrup K.</creatorcontrib><creatorcontrib>Nowsheen, Somaira</creatorcontrib><creatorcontrib>Ramos‐Rodriguez, Alvaro J.</creatorcontrib><creatorcontrib>Bridges, Alina G.</creatorcontrib><creatorcontrib>Lehman, Julia S.</creatorcontrib><creatorcontrib>Hashmi, Shahrukh K.</creatorcontrib><creatorcontrib>el‐Azhary, Rokea A.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hunjan, Manrup K.</au><au>Nowsheen, Somaira</au><au>Ramos‐Rodriguez, Alvaro J.</au><au>Bridges, Alina G.</au><au>Lehman, Julia S.</au><au>Hashmi, Shahrukh K.</au><au>el‐Azhary, Rokea A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemotherapy‐induced skin toxicity and capillary leak syndrome</atitle><jtitle>International journal of dermatology</jtitle><addtitle>Int J Dermatol</addtitle><date>2019-07</date><risdate>2019</risdate><volume>58</volume><issue>7</issue><spage>856</spage><epage>860</epage><pages>856-860</pages><issn>0011-9059</issn><eissn>1365-4632</eissn><abstract>Background
The occurrence of chemotherapy‐related adverse cutaneous reactions in the setting of capillary leak syndrome (CLS) is quite rare. Our objective was to identify the type of skin reactions associated with CLS.
Methods
Leukemia or hematopoietic stem cell transplant patients between January 2010 and December 2017 were identified, and medical records were reviewed for a dermatology consultation occurring concomitantly with CLS.
Results
Five patients were identified, two with a diagnosis of toxic erythema of chemotherapy (TEC) and three others with a skin diagnosis of toxic epidermal necrolysis (TEN). Pathology of all patients was available for clinical‐pathologic confirmation.
Conclusions
Although TEC is generally self‐limited, both TEC and TEN can present with severe adverse skin manifestations during CLS secondary to toxicity from chemotherapy.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30847892</pmid><doi>10.1111/ijd.14392</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Chemotherapy Consultation Dermatology Diagnosis Erythema Hematopoietic stem cells Leukemia Medical records Patients Skin Stem cells Toxic epidermal necrolysis Toxicity |
| title | Chemotherapy‐induced skin toxicity and capillary leak syndrome |
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