Design, synthesis, bioactivity, and DFT calculation of 2-thiazolyl-hydrazone derivatives as influenza neuraminidase inhibitors

Three series of thiazolylhydrazone derivatives were designed, synthesized, and evaluated for their neuraminidase (NA) inhibitory activity against influenza virus H1N1 in vitro. Compounds 1 and 2 were synthesized via the one-pot reaction and compound 3 was synthesized in two steps. Pharmacological re...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Medicinal chemistry research 2019-07, Vol.28 (7), p.938-947
Hauptverfasser:	Cui, Man-Ying, Nie, Jian-Xia, Yan, Zhong-Zhong, Xiao, Meng-Wu, Lin, Ding, Ye, Jiao, Hu, Ai-Xi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological activity Biological effects Biomedical and Life Sciences Biomedicine Cell Biology Compound A Density functional theory Derivatives Exo-a-sialidase Hydrazones Influenza Lead compounds Mathematical analysis Molecular docking Original Research Pharmacology Pharmacology/Toxicology Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!